Plasma lipids, lipoproteins and apolipoproteins in hirsute women

Castelo-Branco, Camil; Casals, Elena; Osaba, Marı́a J. Martı́nez de; Sanllehy, C; Fortuny, Albert

doi:10.3109/00016349609047098

Cited by 5 publications

(2 citation statements)

References 23 publications

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“…It has been previously shown that a relative hyperandrogenicity in women is associated with a powerful risk of developing type 2 diabetes mellitus, cardiovascular diseases, hypertension and endometrial cancer followed by premature mortality (5). However, some studies have claimed that testosterone in women acts as a protector against cardiovascular risk (6,26) which coincides with our present findings.…”

Section: Discussionsupporting

confidence: 90%

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Interrelationship between serum lipid profile, serum hormones and other components of the metabolic syndrome

Garaulet

Pérez‐Llamas

Zamora

et al. 2002

J. Physiol. Biochem.

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The aim of the present study was to investigate the association between the serum lipid profile and components of the metabolic syndrome, such as central obesity (anthropometric, computed tomography and fat cell data), insulin, sex-hormone-binding-globulin (SHBG) and different hormones influencing this important syndrome, e.g. sex steroids, leptin and tumor necrosis factor-alpha (TNF-alpha). The sample consisted of 85 obese patients (30 men and 55 women) who had undergone abdominal surgery. Fasting serum lipids were analysed, as well as anthropometric and computed tomography data, perivisceral and subcutaneous fat cell size and serum glucose and hormones. Abdominal fat revealed itself as an important correlator of the adverse changes in plasma lipoprotein levels, the waist-to-hip-ratio and waist-to-thigh-ratio being the best morphological correlators in men and women, respectively. Intra-abdominal fat (VA) correlated significantly and positively to perivisceral fat cell size in women, while no correlation was found between subcutaneous fat accumulation (SA) and adipocyte size in both genders. Perivisceral fat cell size showed the greatest number of correlations with the adverse plasma lipid profile compared to that in the subcutaneous depot. SHBG and sex steroids showed a negative correlation with serum lipids considered a cardiovascular risk. In contrast, TNF-alpha and C-peptide were inversely correlated with potential protector lipids. In conclusion, abdominal obesity, adipocyte hypertrophy from visceral fat, serum TNF-alpha and C-peptide seem to be the best correlators of the lipoprotein disturbance characteristic of the metabolic syndrome, whereas SHBG and sex steroids could play a protective role regarding the lipid profile associated to this syndrome.

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Section: Discussionsupporting

confidence: 90%

“…This fact might contribute to the metabolic syndrome in susceptible individuals, but there is conflicting information about the particular relationship between the different hormones and the serum lipid profile (5,13,28).…”

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confidence: 99%