Estrogens as Antioxidant Modulators in Human Fertility

Mancini, Antonio; Raimondo, Sebastiano; Persano, Mariasara; Segni, Chantal Di; Cammarano, Michela; Gadotti, Giovanni; Silvestrini, Andrea; Pontecorvi, Alfredo; Meucci, Elisabetta

doi:10.1155/2013/607939

Cited by 16 publications

(10 citation statements)

References 57 publications

(52 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…NF-kB) activated by oxidative stress (Nandakumar et al 2008;Morgan & Liu 2011). Based upon a variety of studies, it appears that female hosts tend to have stronger anti-oxidant defense responses than their male counterparts (Borras et al 2003;Badeau et al 2005;Vina et al 2011;Mancini et al 2013). For example, it has been reported that mitochondria from Wistar rats of control females produced only half of the levels of peroxides compared with males and ovariectomized females (Borras et al 2003).…”

Section: Discussionmentioning

confidence: 99%

Sex-based differences in lymphocyte proliferation in the spleen after vanadium inhalation

Rodríguez-Lara

Cambas

Villalva

et al. 2016

Journal of Immunotoxicology

View full text Add to dashboard Cite

Vanadium (V) is a transition metal often adhered to particulate matter and released into the atmosphere as vanadium pentoxide (V 2 O 5 ) by the burning of fossil fuels. This air pollutant causes adverse effects in the immune system. Lymphocytosis and splenomegaly have been reported with increased white pulp in mice after V inhalation. The effect of V on the immune system as related to sex has been poorly investigated. This study sought to determine if V inhalation (a) produced lymphoproliferation that could explain the changes previously observed in the spleen and in peripheral blood lymphocyte counts and (b) whether any observed effects differed due to gender. Immunohistochemical analyses of Ki-67, a specific proliferation marker, was made in the spleens of CD-1 male and female mice exposed for 1 h, twice a week, over a 12-week period to V 2 O 5 (at 1.4 mg V 2 O 5 /m 3 ) by whole-body inhalation; similar analyses were performed on spleens of control mice exposed to vehicle (filtered air). The results showed that in male mice there was a significant increase in percentage of Ki-67 immunopositive lymphocytes starting from the second week and until the end of the exposure. The Ki-67 signal was cytoplasmic and nuclear in the exposed males, while in controls the signal was only nuclear. In female mice, V inhalation singificantly increased the percentage of proliferating lymphocytes only after 1 week of exposure. Ki-67 signal was observed only in the nucleus of lymphocytes from the control and exposed females. The results here help to explain the splenomegaly and lymphocytosis observed previously in male mice and support the lymphoproliferative effect induced by V. Lastly, the finding that there was a sex difference in the effect of vanadium on lymphocyte proliferation suggests a role for sex hormones in potential protection against V immunotoxicity; however, further studies are needed to support this hypothesis. ARTICLE HISTORY

show abstract

Section: Discussionmentioning

confidence: 99%

Sex-based differences in lymphocyte proliferation in the spleen after vanadium inhalation

Rodríguez-Lara

Cambas

Villalva

et al. 2016

Journal of Immunotoxicology

View full text Add to dashboard Cite

show abstract

“…Beyond the general beliefs stress can be defined also at cellular level as an oxidative stimulus. Oxidative stress (OS) is an unbalance between production of free radicals, molecules characterized by high reactivity (like reactive oxygen species (ROS) such as superoxide anion, hydrogen peroxide, and the hydroxyl radical) and antioxidant (such as glutathione, vitamins, catalase, superoxide dismutase, and various peroxidases) defenses in biological systems ( Figure 3 ) [ 16 ]. Enhancement in ROS and their metabolites can attack the cell membrane, and they can result in modification of the DNA, lipids, and proteins (such as tyrosine nitration and S-glutathionylation), altering enzymatic systems.…”

Section: Introductionmentioning

confidence: 99%

“…On the other hand, in leukocytes and many other cells (endothelial cells, mesangial cells, fibroblasts, thyrocytes, oocytes, Leydig cells, adipocytes, etc.) ROS generation has been assessed to have a positive physiological role protecting the cells from pathological stimuli [ 16 ].…”

Section: Introductionmentioning

confidence: 99%

The Janus Face of Stress on Reproduction: From Health to Disease

Zelena

2015

International Journal of Endocrinology

View full text Add to dashboard Cite

Parenthood is a fundamental feature of all known life. However, infertility has been recognized as a public health issue worldwide. But even when the offspring are conceived, in utero problems can lead to immediate (abortion), early (birth), and late (adulthood) consequences. One of the most studied factors is stress. However, stress response is, per se, of adaptive nature allowing the organism to cope with challenges. Stressors lead to deterioration if one is faced with too long lasting, too many, and seemingly unsolvable situations. In stress adaptation the hypothalamus-pituitary-adrenocortical axis and the resulting glucocorticoid elevation are one of the most important mechanisms. At cellular level stress can be defined as an unbalance between production of free radicals and antioxidant defenses. Oxidative stress is widely accepted as an important pathogenic mechanism in different diseases including infertility. On the other hand, the goal of free radical production is to protect the cells from infectious entities. This review aims to summarize the negative and positive influence of stress on reproduction as a process leading to healthy progeny. Special emphasis was given to the balance at the level of the organism and cells.

show abstract

“…Total antioxidant capacity (TAC) expresses the whole effects of nonproteic nonenzymatic antioxidants, as widely discussed in previous studies [21,22]. Previously, we have shown the modulatory action of anabolic hormones on this parameter and its variations in CHF [20,23].…”

Section: Introductionmentioning

confidence: 99%

Anabolic Hormone Deficiencies in Heart Failure with Reduced or Preserved Ejection Fraction and Correlation with Plasma Total Antioxidant Capacity

Mancini

Fuvuzzi

Bruno

et al. 2020

International Journal of Endocrinology

Self Cite

View full text Add to dashboard Cite

Background. While anabolic hormone deficit is a common finding in heart failure with reduced ejection fraction (HFrEF), few data are available in heart failure with preserved ejection fraction (HFpEF). Methods. Blood samples were collected for metabolic (total cholesterol, HDL cholesterol, LDL cholesterol, creatinine, and glucose) and hormonal (IGF-1, DHEA-S, TSH, fT3, fT4, and T) determination, comparing 30 patients with HFpEF and 20 patients with HFrEF. Total antioxidant capacity was evaluated by using the spectrophotometric method using the latency time in the appearance of the radical species of a chromogen (LAG, sec) as a parameter proportional to antioxidant content of the sample. Echocardiographic parameters were also assessed in the two groups. Results. A high prevalence of testosterone (32% in HFrEF and 72% in HFpEF, p<0.05) and DHEA-S deficiencies was observed in HFpEF patients. Echocardiographic parameters did not correlate with hormone values. A significant direct correlation between T (r2 = 0.25, p<0.05) and DHEA-S (r2 = 0.19, p<0.05) with LAG was observed only in HFpEF. Conclusion. Anabolic hormone deficiency is clearly shown in HFpEF, as already known in HFrEF. Although longitudinal studies are required to confirm the prognostic value of this observation, our data suggest different mechanisms in modulating antioxidants in the two conditions, with possible therapeutic implications.

show abstract

Estrogens as Antioxidant Modulators in Human Fertility

Cited by 16 publications

References 57 publications

Sex-based differences in lymphocyte proliferation in the spleen after vanadium inhalation

Sex-based differences in lymphocyte proliferation in the spleen after vanadium inhalation

The Janus Face of Stress on Reproduction: From Health to Disease

Anabolic Hormone Deficiencies in Heart Failure with Reduced or Preserved Ejection Fraction and Correlation with Plasma Total Antioxidant Capacity

Contact Info

Product

Resources

About