Estrus-Inhibiting Effects of Inanition

Mulinos, Michael G.; Pomerantz, Leo; Smelser, Jane; Kurzrok, Raphael

doi:10.3181/00379727-40-10312

Cited by 23 publications

(12 citation statements)

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“…Deficiency of the Vitamin B complex also leads, in rats, to anestrus and atrophied ovaries; these ovaries are still responsive to follicle stimulating hormone (14,15,16). The anestrus in vitamin B deficiency in rats may likewise be due to an inadequate protein intake.…”

Section: Follicle Stimulating Hormone Excretion Inmentioning

confidence: 99%

Experience with a Quantitative Test for Normal or Decreased Amounts of Follicle Stimulating Hormone in the Urine in Endocrinological Diagnosis

Klinefelter

Albright

Griswold

1943

The Journal of Clinical Endocrinology & Metabolism

401

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Section: Follicle Stimulating Hormone Excretion Inmentioning

confidence: 99%

Experience with a Quantitative Test for Normal or Decreased Amounts of Follicle Stimulating Hormone in the Urine in Endocrinological Diagnosis

Klinefelter

Albright

Griswold

1943

The Journal of Clinical Endocrinology & Metabolism

401

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“…Starvation impairs reproductive performance in man and animals (Loeb 1921;Mulinos et al 1939;Dickerson et al 1964;Stein & Sussar 1978). It affects the secretion of anterior pituitary hormones (Campbell et al 1977) and leads to amenorrhoea or anoestrus, respectively.…”

mentioning

confidence: 99%

Starvation induced anoestrus: effect of chronic food restriction on body weight, its influence on oestrous cycle and gonadotrophin secretion in rats

Knuth

Friesen

1983

Acta Endocrinologica

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To test the effect of chronic starvartion on gonadotrophin secretion and oestrous cycles, rats were fed 50% of their normal chow consumption for 16 days. This caused an increasing rate of anoestrus which became significant during the third expected cycle (6 of 10 rats, P < 0.02) and increased to 8 of 10 rats (P < 0.0001) between day 12 and 16. The accompanying weight loss was around 13 and 17%, respectively. Pituitary weights in intact rats killed on dioestrus became significantly different after 8 days of chow reduction (12.8 \ m=+-\ 0.2 vs 11.3 \m=+-\0.4 mg, P < 0.02) with further reductions in groups killed after 12 and 16 days. At this time dioestrous serum FSH levels were significantly inceased in starved rats (112 \ m=+-\16 vs 161 \m=+-\ 13 ng/ml, P < 0.01), while serum LH levels decreased significantly after 12 days (25.0 \ m=+-\ 3.4 vs 13.1 \ m=+-\ 8.8 ng/ml, P < 0.001). Starvation decreased the LH response to LRH administration compared to pro-oestrous controls (1934 \ m=+-\ 672 vs 289 \ m=+-\ 39 ng/ml, P < 0.05), whereas the FSH response was not impaired (457 \ m=+-\ 91 vs 336 \ m=+-\ 54 ng/ml, P > 0.05). In contrast to this pituitary content of LH was similar in both groups, while FSH content was significantly higher in starved animals (13.6 \ m=+-\1.7 vs 19.8 \m=+-\1.2 \g=m\g, P < 0.01). Chronic starvation immediately after ovariectomy did not affect the post-castrational rise of gonadotrophins. However, LRH administration caused higher serum FSH levels in starved rats (1540 \ m=+-\ 91 vs 1833 \ m=+-\ 90 ng/ml, P < 0.05), whereas LH values did not differ (908 \m=+-\192 vs 721 \ m=+-\ 153 ng/ml, P> 0.05). Gonadotrophin content per pituitary in castrated rats after 16 days of starvation was unchanged.

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“…Vagotomized rats also exhibit decreased gastric acid secretion (Legros & Griffith, 1969), stomach distension (Shay, Komarov & Guenstein, 1949;Ellis & Pryse Davies, 1967;Mordes et ai, 1979) and reduced gastric emptying (Shay et ai, 1949;Mordes et ai, 1979). Restrictions in food intake have been shown to suppress both LH release (Howland, 1971(Howland, , 1972(Howland, , 1976 and oestrous cyclicity (Mulinos, Pomerantz, Smelser & Kurzok, 1939;Werner, 1939;Drill & Burrill, 1944;Maddock & Heller, 1947;Piacsek & Meites, 1967;Nakanishi, Mori & Nagasawa, 1976). It is possible that decreased body weight may have contributed to the suppression of LH and oestrous cyclicity in the present study.…”

Section: Discussionmentioning

confidence: 66%

Effects of abdominal vagotomy on serum LH concentrations in female rats

Allen¹,

Lawrence²,

Burden³

et al. 1985

Reproduction

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Vagotomy on the morning of pro-oestrus did not prevent the pro-oestrous LH surge and rats became oestrous on the following day. However, vagotomized rats then exhibited a period of acyclicity which lasted for 20\m=.\4\m=+-\1\m=.\3 (s.e.m.) days. Food intake and body weight also declined after vagotomy. During the first week after vagotomy, afternoon LH surges generally did not occur, a pattern which was similar in animals pair fed with vagotomized rats. However, pair-fed rats showed oestrous cycles while vagotomized rats were acyclic. At 7 days after vagotomy, LH surges were induced by oestradiol benzoate and progesterone treatment of ovariectomized rats. Vagotomy suppressed the post-ovariectomy increase in serum LH at 7 and 21 days after surgery. These results, combined with those of other studies, suggest impairment of LH release in vagotomized rats.

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Estrus-Inhibiting Effects of Inanition

Cited by 23 publications

References 0 publications

Experience with a Quantitative Test for Normal or Decreased Amounts of Follicle Stimulating Hormone in the Urine in Endocrinological Diagnosis

Experience with a Quantitative Test for Normal or Decreased Amounts of Follicle Stimulating Hormone in the Urine in Endocrinological Diagnosis

Starvation induced anoestrus: effect of chronic food restriction on body weight, its influence on oestrous cycle and gonadotrophin secretion in rats

Effects of abdominal vagotomy on serum LH concentrations in female rats

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