Estudio de un protocolo de desintoxicación rápida en pacientes dependientes de opiáceos en una unidad de cuidados intensivos: resultados preliminares

Intervention: Antagonist-induced Comparison: conventional Illustrative comparative risks* (95% CI) Outcomes Assumed risk Corresponding risk Relative effect (95% CI) No of Participants (studies) Quality of the evidence (GRADE) Comments conventional Antagonist-induced Medium risk population Number completing detoxification 576 per 1000 818 per 1000 (628 to 1060) RR 1.42 (1.09 to 1.84) 100 (2) ⊕⊕⊝⊝ low 1,2 Medium risk population Number commencing naltrexone maintenance treatment-Clonidine comparison 177 per 1000 758 per 1000 (515 to 1115) RR 4.28 (2.91 to 6.3) 240 (3) ⊕⊕⊕⊝ moderate 2 Medium risk population Number commencing naltrexone maintenance treatment-Buprenorphine comparison 730 per 1000 942 per 1000 (759 to 1168) RR 1.29 (1.04 to 1.6) 72 (1) ⊕⊕⊕⊝ moderate 2 Medium risk population Retained in naltrexone maintenance treatment or abstinent at 12 weeks-Tapered methadone comparison 333 per 1000 666 per 1000 (300 to 1482) RR 2 (0.9 to 4.45) 30 (1) ⊕⊕⊝⊝ low 1,2 Medium risk population Retained in naltrexone maintenance treatment or abstinent at 12 weeks-Clonidine comparison 88 per 1000 244 per 1000 (121 to 494) RR 2.77 (1.37 to 5.61) 240 (3) ⊕⊕⊕⊝ moderate 2 Cochrane Library Trusted evidence. Informed decisions. Better health.

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Pharmacological therapies for management of opium withdrawal

Rahimi-Movaghar

Gholami

Amato³

et al. 2018

Cochrane Database of Systematic Reviews

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Results did not support using any specific pharmacological approach for the management of opium withdrawal due to generally very low-quality evidence and small or no differences between treatments. However, it seems that opium withdrawal symptoms are significant, especially at days 2 to 4 after discontinuation of opium. All of the assessed medications might be useful in alleviating symptoms. Those who receive clonidine might experience hypotension.

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Estudio de un protocolo de desintoxicación rápida en pacientes dependientes de opiáceos en una unidad de cuidados intensivos: resultados preliminares

Cited by 3 publications

References 19 publications

Opioid antagonists under heavy sedation or anaesthesia for opioid withdrawal

Opioid antagonists under heavy sedation or anaesthesia for opioid withdrawal

Opioid antagonists under heavy sedation or anaesthesia for opioid withdrawal

Pharmacological therapies for management of opium withdrawal

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