Estudo químico e biológico de Tephrosia toxicaria Pers.

Vasconcelos, Jackson Nunes e; Lima, Jefferson Queiroz; Lemos, Telma L. G.; Oliveira, Maria da Conceição Ferreira de; Almeida, Maria Mozarina Beserra; Andrade‐Neto, Manoel; Mafezoli, Jair; Arriaga, Ângela M. C.; Santiago, Gilvandete Maria Pinheiro; Braz‐Filho, Raimundo

doi:10.1590/s0100-40422009000200021

Cited by 18 publications

(11 citation statements)

References 30 publications

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“…The anticancer (Kim et al, 2008) and insecticide (Khater, 2012) activities of degelin isolated from natural sources have been reported. Furthermore, the cancer chemopreventive properties of T. toxicaria were attributed to bioactive metabolites (Jang et al, 2003;Vasconcelos et al, 2009).…”

Section: Brine Shrimp Toxicity Testmentioning

confidence: 99%

Antimicrobial activity of Brazilian plants of the genera Leguminosae and Myrtaceae

Daniel¹,

Iwasso²,

Fiorini³

et al. 2014

J. Med. Plants Res.

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Five Brazilian plant extracts from Pimenta pseudocaryophyllus, Erythrina speciosa, Tephrosia toxicaria, Inga marginata and Cassia leptophylla found in Paraná State and currently used in folkloric medicines, were assayed for antibacterial, antifungal and toxic activities. The antibacterial and anti-yeast activities were assessed by a diffusion assay on Gram (+) bacteria (Bacillus subtilis and Staphylococcus aureus), Gram (-) bacteria (Escherichia coli and Pseudomonas aeruginosa), and the yeasts (Candida albicans, Candida krusei, and Candida tropicalis). The extracts were also tested against the phytopathogenic fungi (Lasiodiplodia theobromae, Botryosphaeria ribis, Botryosphaeria rhodina, and Fusarium verticillioides) by growth inhibition using Captan™ as control. The toxicity was evaluated in Artemia salina through LC 50 (50% median lethal concentration) using Probit analysis. P. aeruginosa was inhibited by P. pseudocaryophyllus stems, E. speciosa and C. lephophylla leaves. E. coli by P. pseudocaryophyllus stems, B. subtilis by C. leptophylla leaves, and T. toxicaria roots. C. albicans by P. pseudocaryophyllus stems and E. speciosa leaves, while C. krusei by P. pseudocaryophyllus stems, and C. tropicalis by P. pseudocaryophyllus leaves, E. speciosa leaves and I. marginata leaves. E. speciosa and P. pseudocaryophyllus leaf extracts also inhibited all the phytopathogenic fungi examined. T. toxicaria roots showed stronger toxicity towards A. salina.

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Section: Brine Shrimp Toxicity Testmentioning

confidence: 99%

Antimicrobial activity of Brazilian plants of the genera Leguminosae and Myrtaceae

Daniel¹,

Iwasso²,

Fiorini³

et al. 2014

J. Med. Plants Res.

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“…Flavonoids with antioxidant effects are beneficial in malaria infection (Ferreira et al, 2010). an IC 50 value of 3.37 μg/mL (Vasconcelos et al, 2009;Chen et al, 1978). Therefore, there is a need to pursue investigations on the the aerial parts of Tephrosia subtriflora along with known compounds are reported so far identified in order to foster and standardize their use either as herbal medicines or sources of new drug candidate molecules or isolate pure compound.…”

Section: Introductionmentioning

confidence: 99%

Antiplasmodial Flavanonol From Tephrosia Subtriflora With Radical Scavenging Activity

Mutai¹

2017

WJPPS

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“…Species of this genus are known by their larvicidal, antiviral, anticancer, hepatoprotective and antioxidant activities (Andel et al, 2000;Andrei et al, 1997Andrei et al, , 2000Jang et al, 2003;Khatri et al, 2009;Niassy et al, 2005;Pezzuto et al, 1999;Saleem et al, 2001;Vasconcelos et al, 2009;Yenesew et al, 2006).…”

Section: Introductionmentioning

confidence: 99%

“…(Fabaceae) (syn. Tephrosia toxicaria) has insecticide and anticancer activities (Arriaga et al, 2009b;Arroio et al, 2004;Jang et al, 2003;Ribeiro et al, 2006;Vasconcelos et al, 2009). Preliminary data on the composition analysis of ethyl acetate extract of T. sinapou revealed the presence of flavonoids, including novel compounds.…”

Section: Introductionmentioning

confidence: 99%

Tephrosia sinapouethyl acetate extract inhibits inflammatory pain in mice: Opioid receptor dependent inhibition of TNFαand IL-1βproduction

Martínez¹,

Zarpelon²,

Cardoso³

et al. 2013

Pharmaceutical Biology

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Context: Tephrosia toxicaria is currently known as Tephrosia sinapou (Buc'hoz) A. Chev. (Fabaceae) and is a source of compounds such as flavonoids that inhibit inflammatory pain. Objective: To investigate the analgesic effect and mechanisms of the ethyl acetate extract of T. sinapou in inflammatory pain in mice. Materials and methods: Behavioral responses were evaluated using mechanical (1-24 h) and thermal hyperalgesia (0.5-5 h), writhing response (20 min) and rota-rod (1-5 h) tests. Neutrophil recruitment (myeloperoxidase activity), cytokines (tumor necrosis factor [TNF]a and interleukin [IL]-1b), aspartate aminotransferase (AST) and alanine aminotransferase (ALT) serum levels were determined by colorimetric assays. Pharmacological treatments were opioid receptor antagonist (naloxone, 0.1-1 mg/kg) and control opioid (morphine, 5 mg/kg). Inflammatory stimuli were carrageenin (100 mg/paw), complete Freund's adjuvant (CFA, 10 ml/paw), prostaglandin E 2 (PGE 2 , 100 ng/paw) and acetic acid (0.8%). Results: The intraperitoneal pre-treatment with extract inhibited in a dose-dependent (30-300 mg/kg) dependent manner the mechanical hyperalgesia induced by carrageenin (up to 93% inhibition). The post-treatment (100 mg/kg) inhibited CFA-induced hyperalgesia (up to 63% inhibition). Naloxone (1 mg/kg) prevented the inhibitory effect of the extract over carrageenin-induced mechanical (100%) and thermal (100%) hyperalgesia, neutrophil recruitment (52%) and TNFa (63%) and IL-1b (98%) production, thermal threshold in naïve mice (99%), PGE 2 -induced mechanical hyperalgesia (88%) and acetic acid-induced writhing response (49%). There was no significant alteration in the rota-rod test, and AST and ALT serum levels by extract treatment. Discussion and conclusion: Tephrosia sinapou ethyl acetate extract reduces inflammatory pain by activating an opioid receptor-dependent mechanism.

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Estudo químico e biológico de Tephrosia toxicaria Pers.

Cited by 18 publications

References 30 publications

Antimicrobial activity of Brazilian plants of the genera Leguminosae and Myrtaceae

Antimicrobial activity of Brazilian plants of the genera Leguminosae and Myrtaceae

Antiplasmodial Flavanonol From Tephrosia Subtriflora With Radical Scavenging Activity

Tephrosia sinapouethyl acetate extract inhibits inflammatory pain in mice: Opioid receptor dependent inhibition of TNFαand IL-1βproduction

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