Etanercept in the treatment of ankylosing spondylitis and nephrotic syndrome in the context of AA amyloidosis: A 48-month follow-up

Domingos, Ana; Vidinha, Joana; Osório, Rui; Jerónimo, Teresa; Ribeiro, Cristina; Mendonça, Catarina; Góis, Mário; Neves, Pedro Leão

doi:10.1016/j.nefro.2020.04.019

Cited by 1 publication

(2 citation statements)

References 2 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…High ESR has been reported as an independent predictive factor for renal AA amyloidosis 8 . In the present study, we highlight a case previously reported by Domingos et al 4 . The patient presented with nephrotic syndrome and ERS >100 mm/h at the time of kidney biopsy and was successfully treated with etanercept.…”

Section: Discussionsupporting

confidence: 77%

“…Recently, Domingos et al 4 reported the case of a 78-year-old woman with a seronegative polyarthritis evolving for 10 years and corticoid-induced diabetes mellitus who presented to the nephrology department for NS (anasarca, sCr of 1.3 mg/dL, 10.4 g/24h of proteinuria, and hypoalbuminemia of 1.4 g/dL). She also complained of constitutional symptoms, diarrhea, and inflammatory arthralgia.…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Kidney Disease in Ankylosing Spondylitis: a case series and review of the literature

et al. 2023

Self Cite

View full text Add to dashboard Cite

Background Kidney disease is a rare manifestation of ankylosing spondylitis (AS) and its pathological alterations remain poorly described. The aim of this study was to investigate the clinical presentation and pathological alterations on kidney biopsy of AS patients and review and discuss the current literature on the issue. Methods: We retrospectively studied the clinical presentation and kidney pathological alterations of 15 Caucasian AS patients submitted to kidney biopsy between October 1985 and March 2021. Results: Patients were predominantly male (66.7%) with median age at the time of kideney biopsy of 47 years [IQR 34 - 62]. Median serum creatinine at presentation was 1.3 mg/dL [IQR 0.9 - 3] and most patients also had either proteinuria (85.7%) and/or hematuria (42.8%). The most common indication for kidney biopsy was nephrotic syndrome (33.3%), followed by acute or rapidly progressive kidney injury (20%) and chronic kidney disease of unknown etiology (20%). Chronic interstitial nephritis (CIN) (n=3) and AA amyloidosis (n=3) were the most common diagnosis. Others included IgA nephropathy (IgAN) (n=2), focal segmental glomerulosclerosis (n=2), membranous nephropathy (n=1), and immune complex-mediated membranoproliferative glomerulonephritis (IC-MPGN)(n=1). Conclusions: We present one of the largest series of biopsy-proven kidney disease in Caucasian AS patients. We found a lower prevalence of IgAN than previously reported in Asian cohorts. We found a higher prevalence of CIN and a lower prevalence of AA amyloidosis than that described in previous series of Caucasian patients. We also present the first case of AS-associated IC-MPGN.

show abstract

Section: Discussionsupporting

confidence: 77%

Section: Resultsmentioning

confidence: 99%