Etanercept-Induced Lupus Erythematosus Presenting as a Unilateral Pleural Effusion

Etanercept-induced pleuropericardial lupus-like syndrome: Fig. 1—

“…Isoniazide-induced effusion was deemed unlikely: the first effusion appeared without the patient taking the drug and the patient displayed systemic manifestations. The low pH and the eosinophils present in the first effusion have not been reported previously [7] and were ascribed to intense inflammation. A dose of 0.5 mg?kg -1 oral prednisolone was installed, with prompt clinical and radiological resolution and the patient remained well after 16 months of follow-up.…”

Updated consensus statement on biological agents for the treatment of rheumatic diseases, 2011

“…Autoantibody formation is common after TNF inhibitor therapy (eg, antinuclear antibodies), but clinical syndromes associated with these antibodies are rare (category C, D evidence325 397 398). …”

Updated consensus statement on biological agents for the treatment of rheumatic diseases, 2010

“…Golimumab and certolizumab pegol have been recently approved for the treatment of RA and demonstrated efficacy in clinical trials similar to that of other TNFα blocking agents in improving signs and symptoms, physical function, health-related QoL and reducing252 256 257 the radiographic progression of patients with RA (category A evidence282–285). The adverse event profile is consistent with that of other TNFα blockers.…”

“…Autoantibody formation is common after TNFα blocker therapy (eg, antinuclear antibodies), but clinical syndromes associated with these antibodies are rare (category C evidence282 283). …”