Etching of Blood Proteins in the Early and Late Flowing Afterglow of Oxygen Plasma

Vesel, Alenka; Kolar, Mitja; Recek, Nina; Kutasi, Kinga; Stana‐Kleinschek, Karin

doi:10.1002/ppap.201300067

Cited by 26 publications

(19 citation statements)

References 34 publications

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“…However, due to lack of data at this stage, no other reactions in the overall chemical pathway can be proposed. Recent works on proteins by Vesel et al showed a synergetic effect of O and O 2 (a), i.e., a pathway that could match with the present inferred scheme where the singlet state of oxygen is proposed to help open the ring once a radical is formed from hydrogen abstraction by atomic oxygen. According to these authors, O 3 does not play a significant role in afterglow.…”

Section: Resultssupporting

confidence: 82%

“…Mozetič showed how to control oxidation of some organic compounds in oxygen plasma . The same group investigated in 2014 the interaction of early and late afterglows with blood proteins, revealing a synergetic effect of O and O 2 (a) species involved the etching process. We showed how O atoms and O 2 molecules interact with CC and CH bonds by understanding the oxidation mechanisms at low temperature (i.e., below the melting point of the studied materials) of hexatriacontane (C 36 H 74 ), a long chain alkane .…”

Section: Introductionmentioning

confidence: 99%

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Treatment of Glycine and Proline in Late Ar‐O₂ Afterglow

Nominé

Mafra

Frache

et al. 2015

Plasma Processes & Polymers

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Glycine and proline have been treated in Ar-O 2 afterglows at low temperature to study their modification in highly reactive non-equilibrium media. These two amino-acids can be efficiently etched in suited conditions. In the case of glycine, O( 3 P) is the main reactive species responsible for the etching mechanism. It reacts preferentially with the -CH 2 -group instead of the amine group -NH 2 . Further oxidation processes are observed but they are not rate-limiting. Etching of proline is a multi-step process, probably initiated by O( 3 P) and then followed by reactions which control the etch-rate, the opening of the non-aromatic ring of proline being a probable route.

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Section: Resultssupporting

confidence: 82%

Section: Introductionmentioning

confidence: 99%

Treatment of Glycine and Proline in Late Ar‐O₂ Afterglow

Nominé

Mafra

Frache

et al. 2015

Plasma Processes & Polymers

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“…A good candidate can be O 2 (a) molecules, but unfortunately, there exists no technique for determination of their concentration. As shown in our recent paper, etching is actually due to synergistic effect between O‐atoms and O 2 (a) molecules . The etching rate is increasing with the increasing pressure (see also Fig.…”

Section: Resultssupporting

confidence: 63%

Etching rates of blood proteins, blood plasma and polymer in oxygen afterglow of microwave plasma

Vesel

Kolar

Stana‐Kleinschek

2014

Surface & Interface Analysis

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The removal of biomolecules from medical instruments by plasma could be a difficult task due to the fact that many medical instruments are made of polymers, which can be etched in plasma as well. The etching rates of selected blood proteins, platelet‐poor plasma (PPP) and polymer polyethylene terephthalate (PET) were studied. In the case of blood proteins, fibrinogen (FIB) and human serum albumin (HSA) were used. Films of PPP, FIB, HSA and PET were deposited on the quartz crystals and exposed to oxygen atoms in early and late afterglow of microwave plasma at different pressures between 50 and 400 Pa. The thickness of the films versus etching time was measured by quartz crystal microbalance. The thickness of PET film decreased linearly with etching time, while the thickness of both protein films and PPP decreased exponentially with time. In all cases, the etching rates were first increasing with the increasing pressure, while later they reached a constant value. Furthermore, the etching rates were higher in the early afterglow than in the late afterglow. The etching rates of PPP were higher than the etching rates of both proteins HSA and FIB. The slowest etching rate was observed for PET polymer, where the etching rate was lower by two orders of magnitude in comparison to both proteins and PPP. Copyright © 2014 John Wiley & Sons, Ltd.

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“…In such conditions the pressure in the treatment chamber was 50 Pa. In case the working gas was oxygen, the concentration of neutral oxygen atoms in the ground state at the position next to the sample was approximately 7 × 10 20 m −3 [19], whereas, in the case of nitrogen, the dissociation fraction was somehow lower and the N-atom density was only approximately 4 × 10 20 m −3 . The treatment time for both cases was 30 s.…”

Section: Methodsmentioning

confidence: 99%

Haemostatic Response of Polyethylene Terephthalate Treated by Oxygen and Nitrogen Plasma Afterglows

Kolar

Primc²

2016

International Journal of Polymer Science

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Samples of polymer polyethylene terephthalate were coated with heparin and the haemostatic response has been determined by optical imaging of samples after incubation with fresh blood from a healthy donor. Prior to coating the samples were treated by neutral reactive particles of the oxygen or nitrogen plasma flowing afterglow. X-ray photoelectron spectroscopy analysis showed intensive functionalization of the polymer foils upon treatment with afterglows; however, the concentration of sulphur from heparin remained below the detection limit. The optical imaging showed densely distributed blood platelets in highly activated forms on untreated samples, whereas treatment with both afterglows revealed improved hemocompatibility. Best results were obtained for oxygen-functionalized polymer, whereas additional coating with heparin caused moderate loss of hemocompatibility, that was explained by deactivation of surface functional groups upon incubation with heparin.

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Etching of Blood Proteins in the Early and Late Flowing Afterglow of Oxygen Plasma

Cited by 26 publications

References 34 publications

Treatment of Glycine and Proline in Late Ar‐O₂ Afterglow

Treatment of Glycine and Proline in Late Ar‐O₂ Afterglow

Etching rates of blood proteins, blood plasma and polymer in oxygen afterglow of microwave plasma

Haemostatic Response of Polyethylene Terephthalate Treated by Oxygen and Nitrogen Plasma Afterglows

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Etching of Blood Proteins in the Early and Late Flowing Afterglow of Oxygen Plasma

Cited by 26 publications

References 34 publications

Treatment of Glycine and Proline in Late Ar‐O2 Afterglow

Treatment of Glycine and Proline in Late Ar‐O2 Afterglow

Etching rates of blood proteins, blood plasma and polymer in oxygen afterglow of microwave plasma

Haemostatic Response of Polyethylene Terephthalate Treated by Oxygen and Nitrogen Plasma Afterglows

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Product

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Treatment of Glycine and Proline in Late Ar‐O₂ Afterglow

Treatment of Glycine and Proline in Late Ar‐O₂ Afterglow