Ethanol

Kampf, Günter

doi:10.1007/978-3-319-98785-9_2

Cited by 5 publications

(3 citation statements)

References 102 publications

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“…On the other hand, alternative substances that have not been tested on coronaviruses or show a poor performance against SARS-CoV-2, such as organic acids, thymol and PHMB, have also a controversial efficacy against other pathogens and are not recommended. The activity of organic acids is highly dependent of the pH and they are considered as bacteriostatic/fungistatic substances instead of bactericide/fungicide [ 75 ]. In addition, acidophilic organism as acetic bacteria has a high tolerance to organic acids and some bacteria, fungi and yeasts can even employ them as carbon source.…”

Section: Potential Of Sars-cov-2 Disinfectants To Inactivate Othermentioning

confidence: 99%

“…Fortunately, no evidences of genetic resistance have been reported to ethanol, propanol, povidone-iodine and sodium hypochlorite, the most effective disinfectants against SARS-CoV-2. Moreover, broad sense resistance to these substances is, when existing, derived from biofilm formation and thus easily avoidable if proper cleaning is carried out before disinfection [ 75 , 104 ]. However, they have also disadvantages.…”

Section: Disinfection Under the Paradigm Of The “One-health” Appromentioning

confidence: 99%

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A Critical Review of Disinfection Processes to Control SARS-CoV-2 Transmission in the Food Industry

Pedreira

Taşkın

García

2021

Foods

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Industries of the food sector have made a great effort to control SARS-CoV-2 indirect transmission, through objects or surfaces, by updating cleaning and disinfection protocols previously focused on inactivating other pathogens, as well as food spoilage microorganisms. The information, although scarce at the beginning of the COVID-19 pandemic, has started to be sufficiently reliable to avoid over-conservative disinfection procedures. This work reviews the literature to propose a holistic view of the disinfection process where the decision variables, such as type and concentration of active substances, are optimised to guarantee the inactivation of SARS-CoV-2 and other usual pathogens and spoilage microorganisms while minimising possible side-effects on the environment and animal and human health.

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Section: Potential Of Sars-cov-2 Disinfectants To Inactivate Othermentioning

confidence: 99%

Section: Disinfection Under the Paradigm Of The “One-health” Appromentioning

confidence: 99%

A Critical Review of Disinfection Processes to Control SARS-CoV-2 Transmission in the Food Industry

Pedreira

Taşkın

García

2021

Foods

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“…Ethanol is a widely-used disinfectant, but previous research has shown that sub-inhibitory concentrations of ethanol are not only unable to eradicate bacteria but can conversely promote biofilm formation to increase bacterial resistance [ 1 , 2 , 3 , 4 ]. Ethanol concentrations of 2.3–3.5% enhance the ability of Staphylococcus aureus to form biofilms, while 1–2% concentrations are sufficient to induce biofilm formation in Pseudomonas aeruginosa [ 1 , 2 , 3 , 4 ]. The presence of a lcohol d e h ydrogenases (Adhs) can further help bacteria to degrade alcohols, reducing ethanol-induced damage and transforming ethanol into a carbon source for growth instead [ 5 , 6 ].…”

Section: Introductionmentioning

confidence: 99%

Gene Expression of Ethanol and Acetate Metabolic Pathways in the Acinetobacter baumannii EmaSR Regulon

Huang,

Shu,

Lin

2024

Microorganisms

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Background: Previous studies have confirmed the involvement of EmaSR (ethanol metabolism a sensor/regulator) in the regulation of Acinetobacter baumannii ATCC 19606 ethanol and acetate metabolism. RNA-seq analysis further revealed that DJ41_568-571, DJ41_2796, DJ41_3218, and DJ41_3568 regulatory gene clusters potentially participate in ethanol and acetate metabolism under the control of EmaSR. Methods: This study fused the EmaSR regulon promoter segments with reporter genes and used fluorescence expression levels to determine whether EmaSR influences regulon expression in ethanol or acetate salt environments. The enzymatic function and kinetics of significantly regulated regulons were also studied. Results: The EmaSR regulons P2796 and P3218 exhibited > 2-fold increase in fluorescence expression in wild type compared to mutant strains in both ethanol and acetate environments, and PemaR demonstrated a comparable trend. Moreover, increases in DJ41_2796 concentration enhanced the conversion of acetate and succinyl-CoA into acetyl-CoA and succinate, suggesting that DJ41_2796 possesses acetate: succinyl-CoA transferase (ASCT) activity. The kcat/KM values for DJ41_2796 with potassium acetate, sodium acetate, and succinyl-CoA were 0.2131, 0.4547, and 20.4623 mM−1s−1, respectively. Conclusions: In A. baumannii, EmaSR controls genes involved in ethanol and acetate metabolism, and the EmaSR regulon DJ41_2796 was found to possess ASCT activity.

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