Ethanol and a chemical from fox faeces modulate exploratory behaviour in laboratory mice

Grau, Carlos; Leclercq, Julien; Descout, Estelle; Teruel, Eva; Bienboire-Frosini, Cécile; Pageat, Patrick

doi:10.1016/j.applanim.2019.02.003

Cited by 3 publications

(3 citation statements)

References 42 publications

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“…Taken together, the short-term smell effects are not able to develop chronic stress. Our results are close to the findings of Grau et al [6] who have found an avoidance of mice from the ethanol (neutral chemical substance) as well as from the fox faeces and concentrated TMT. Further studies required to elucitate the long-term effects of smells and to differentiate between irritative and species-related effects of smells.…”

supporting

confidence: 92%

Importance of the Olphactory Environment in the Laboratory Animal Science

Fekete

2019

APDV

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The 3 rd R, the refinement is receiving more and more attention. The optimazing of the auditory and olphactory environment of the laboratory animals is essential, because the environmental smells influence the behaviour and occasionally the epigenetics of mammals. According to the characteristics of the smell substances a chemical map is developed in the olphactory bulb. The vomeronasale organ (VNO) has an important role in the pheromonetransfered communication [1]. The VNO is expressing specific major histocompatibility genes, too. In horses and felidae a specific behaviour form, the Flehmen-reaction facilitates pheromone molecules to get the VNO. The intraspecific communication is attained by means of the pheromones, especially in the social and sexual relations. The kairomones are functioning in the communication between species. The interomones are smell compounds influencing the behaviour or physiology of other species, with or without a positive or negative effect for the releaser. Some interomes may decrese the stress of other species [2], having a significance of animal welfare.

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confidence: 92%

Importance of the Olphactory Environment in the Laboratory Animal Science

Fekete

2019

APDV

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“…Custom-built devices ( Figure 1 ) were used as modified open fields to measure the house mouse’s exploratory behaviour, avoidance, and specific anti-predatory and fearful responses to predator stimuli as previously described [ 28 , 29 , 30 ]. Briefly, each device comprised a rectangular arena with a 4 mm thick, 50 × 30 cm glass base covered with a transparent plastic top.…”

Section: Methodsmentioning

confidence: 99%

“…They were then cleaned with white paper towels dampened with water and dried with clean white paper towels. Ethanol was not used, as it elicits avoidance and modifies exploratory behaviour in laboratory mice [ 29 ]. Four identical arenas were rotated between replicates to dissipate possible volatile traces of cleaner product.…”

Section: Methodsmentioning

confidence: 99%

Sex Differences in Mouse Exploratory Behaviour to Fel d 1, a Cat ABP-Like Protein

Grau

Bienboire-Frosini

Arroub

et al. 2021

Animals

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Fel d 1 is a cat protein abundantly released and found in their habitat and is closely related to mouse androgen-binding proteins (ABPs). We hypothesized that mice have developed chemical communication mechanisms to detect and avoid this protein. We tested purified natural Fel d 1, a fox faeces molecule (TMT) as a positive control, and a negative control (purified water) in three different mouse groups (n = 14 each) to evaluate exploratory behaviour and stress responses. The mice did not show clear avoidance or stress responses to Fel d 1. Our results demonstrated a sex-treatment interaction for Fel d 1, with males spending more time in the areas treated with Fel d 1 than in the untreated areas (p = 0.018). This sex-treated area interaction was also not observed for either the blank or TMT. These results suggest that Fel d 1 from domestic cats could be recognized differently by male and female mice. These sex differences could be linked to the sexual role of ABP proteins and the ABP-like characteristics of Fel d 1.

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Laboratory Animal Behaviour and Its Applications in Biomedical Research

Harikrishnan

2021

Essentials of Laboratory Animal Science: Principles and Practices

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Ethanol and a chemical from fox faeces modulate exploratory behaviour in laboratory mice

Cited by 3 publications

References 42 publications

Importance of the Olphactory Environment in the Laboratory Animal Science

Importance of the Olphactory Environment in the Laboratory Animal Science

Sex Differences in Mouse Exploratory Behaviour to Fel d 1, a Cat ABP-Like Protein

Laboratory Animal Behaviour and Its Applications in Biomedical Research

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