Ethanol extracts of black pepper or turmeric down-regulated SIRT1 protein expression in Daudi culture cells

Matsuda, Satoru

doi:10.3892/mmr.2011.487

Cited by 7 publications

(4 citation statements)

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“…Due its medicinal properties, it is used in traditional medicine for its antioxidant, anti-inflammatory and anticancer properties [2,3]. This species is the second most widely traded spice in the world, accounting for a value of 929 million US dollars from a production of 445900 tons in 2009 [4].…”

Section: Introductionmentioning

confidence: 99%

High-throughput sequencing of black pepper root transcriptome

et al. 2012

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BackgroundBlack pepper (Piper nigrum L.) is one of the most popular spices in the world. It is used in cooking and the preservation of food and even has medicinal properties. Losses in production from disease are a major limitation in the culture of this crop. The major diseases are root rot and foot rot, which are results of root infection by Fusarium solani and Phytophtora capsici, respectively. Understanding the molecular interaction between the pathogens and the host’s root region is important for obtaining resistant cultivars by biotechnological breeding. Genetic and molecular data for this species, though, are limited. In this paper, RNA-Seq technology has been employed, for the first time, to describe the root transcriptome of black pepper.ResultsThe root transcriptome of black pepper was sequenced by the NGS SOLiD platform and assembled using the multiple-k method. Blast2Go and orthoMCL methods were used to annotate 10338 unigenes. The 4472 predicted proteins showed about 52% homology with the Arabidopsis proteome. Two root proteomes identified 615 proteins, which seem to define the plant’s root pattern. Simple-sequence repeats were identified that may be useful in studies of genetic diversity and may have applications in biotechnology and ecology.ConclusionsThis dataset of 10338 unigenes is crucially important for the biotechnological breeding of black pepper and the ecogenomics of the Magnoliids, a major group of basal angiosperms.

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Section: Introductionmentioning

confidence: 99%

High-throughput sequencing of black pepper root transcriptome

et al. 2012

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“…Grabowska et al observed that curcumin elevates SIRT1 levels in human vascular cells (12), Sahin et al reported the elevation of SIRT1 and prevention of muscle damage by supplementation of novel watersoluble CW formulation in rats (20), and Ray Hamidie et al showed that Curcumin injection in combination with exercise training increased cytosol NAD+/NADH ratio and SIRT1 protein in Wistar rats muscles (19). But Nishimora et al reported the down regulation of SIRT1 expression with ethanol extract of turmeric in human cells (21).…”

Section: Discussionmentioning

confidence: 99%

Effects of Pilates Training and Turmeric Supplementation on Sirtuin 1 Level and Body Composition in Postmenopausal Females with Sedentary Overweight: A Randomized, Double-Blind, Clinical Trial

Amirsasan

Dolgari

Vakili

2019

Zahedan J Res Med Sci

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Background: Beneficial effects of life style modification (exercise training and nutritional interventions) on improving the quality of life and health status, and preventing age-related pathologies is proven in epidemiologic studies. Objectives: The current randomized, double-blind, clinical trial aimed at evaluating the effects of a 12-week turmeric intake and Pilates training on serum level of SIRT 1, weight, and body fat percentage in postmenopausal females. Methods: The current clinical trial with a four-group design was conducted on 44 sedentary overweight females with the mean age of 50.3 ± 3.8 years randomly assigned to one of the groups receiving 1.5 mg/kg turmeric powder or placebo daily with or without Pilates training for 12 weeks. Serum SIRT1 level, body weight, and body fat percentage changes were analyzed before and 24 hours after the intervention. Pairwise t-test and one-way ANOVA were used for data analysis (P < 0.05). Results: According to the results, a 12-week Pilates and Pilates-turmeric intervention reduced weight and body fat percentage by~8% and 6% respectively, and increased serum SIRT1 content by~2.9 fold (P < 0.01) in the training groups compared with the control group. There were significant differences between the training groups in comparison with the control or turmeric groups in all dependent variables. There was no significant difference between the Pilates and Pilates-turmeric groups. Moreover, no significant difference was observed in dependent variables in the turmeric supplementation group compared with baseline measures or the control group (P ≥ 0.05). Conclusions: Three months of Pilates training with and without turmeric supplementation seemed effective in increasing SIRT1 and improving body composition in middle-aged females. However, the results did not support the hypothesis that turmeric intake alone has potential exercise like effects on healthy middle-aged females.

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“…Black pepper (Piper nigrum L.) is the most traded spice in the world, widely used in cooking, food preservation and perfume production. Some black pepper chemicals also have medicinal properties, such as antioxidant, anti-inflammatory and anticancer activities (Liu et al 2010;Meghwal and Goswami 2013;Nishimura et al 2011). The global production of black pepper from tropical countries is about 334,000 tonnes, totaling 1.8 billion US dollars.…”

Section: Introductionmentioning

confidence: 99%