Ethanol-Induced Conditioned Place Aversion in Rats: Effect of Interstimulus Interval

Bormann, Nancy M.; Cunningham, Christopher L.

doi:10.1016/s0091-3057(97)00455-3

Cited by 39 publications

(22 citation statements)

References 46 publications

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“…or orally by gavage, and outbred rats showed an aversion for the environment associated with ethanol (Asin et al, 1985;Bormann and Cunningham, 1998;Busse et al, 2005;Fidler et al, 2004;Stewart and Grupp, 1981;Stewart et al, 1996;Van der Kooy et al, 1983). Only in three studies, place conditioning was assessed with voluntary ethanol consumption.…”

Section: Discussionmentioning

confidence: 99%

Alcohol Preference Influences the Subthalamic Nucleus Control on Motivation for Alcohol in Rats

Lardeux

Baunez

2007

Neuropsychopharmacol

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In addition to its role in motor and attentional processes, the subthalamic nucleus (STN) has also been recently demonstrated to be involved in motivational function. Indeed, bilateral STN lesions modulate differentially the motivation for natural rewards and drugs of abuse, increasing motivation for food and decreasing motivation for cocaine in rats. Here, we show that in outbred rats, the STN can modulate the motivation for alcohol according to alcohol preference, without affecting alcohol intake. When performed on 'HighDrinker' rats, STN lesions enhanced the breaking point (BP) under a progressive ratio schedule of reinforcement and increased the time spent in the environment previously paired with alcohol access in the place preference paradigm. In contrast, when performed on 'Low-Drinker' rats, STN lesions decreased the BP and increased the time spent in the environment paired with water. These results show that STN lesions enhance the motivation for alcohol in rats showing a high alcohol preference, whereas they decrease it in rats showing a low preference for alcohol. These results suggest that the STN plays a complex role in the reward circuit, that is not limited to a dissociation between motivation for natural rewards and drugs of abuse, but takes other factors, such as alcohol preference, into account.

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Section: Discussionmentioning

confidence: 99%

Alcohol Preference Influences the Subthalamic Nucleus Control on Motivation for Alcohol in Rats

Lardeux

Baunez

2007

Neuropsychopharmacol

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“…In drug naive rats ethanol has generally produced either a conditioned place aversion (CPA) or had no effect (e.g. Asin et al 1985;Bormann and Cunningham 1998). Nevertheless, in rats exposed to (i) ethanol prior to the conditioning sessions, (ii) extended conditioning training, or (iii) confinement to the conditioning chamber immediately after injection, ethanol has produced a CPP (Reid et al 1985;Bozarth 1990;Holloway et al 1992).…”

Section: Discussionmentioning

confidence: 99%

Effects of MDMA exposure on the conditioned place preference produced by other drugs of abuse

et al. 2003

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“…Separate groups of experimentally naive rats were given a single injection of 50 mg/kg i.p. STZ (n ϭ 12) or saline (n ϭ 9) and used to study locomotion and CPP, according to the methods described previously (Bormann and Cunningham, 1998). Locomotor activity and CPP were studied using Plexiglas chambers measuring 26 ϫ 61 ϫ 23 cm in height and located within soundattenuating cubicles.…”

Section: Methodsmentioning

confidence: 99%

Insulin Replacement Restores the Behavioral Effects of Quinpirole and Raclopride in Streptozotocin-Treated Rats

Sevak

Koek²,

Galli

2006

J Pharmacol Exp Ther

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Streptozotocin (STZ)-induced diabetes can modulate dopamine (DA) neurotransmission and thereby modify the behavioral effects of drugs acting on DA systems. Insulin replacement, and in some conditions repeated treatment with amphetamine, can partially restore sensitivity of STZ-treated rats to dopaminergic drugs. The present study sought to characterize the role of insulin and amphetamine in modulating the behavioral effects of drugs that selectively act on D2/D3 receptors. In control rats, quinpirole and quinelorane produced yawning, whereas raclopride and ␥-hydroxybutyric acid (GHB) produced catalepsy. Raclopride antagonized quinpirole-and quinelorane-induced yawning with similar potency. STZ treatment increased blood glucose concentration, decreased body weight, and markedly reduced sensitivity to quinpirole-induced yawning, quinelorane-induced yawning as well as to raclopride-induced catalepsy, while enhancing sensitivity to GHB-induced catalepsy. Repeated treatment with amphetamine partially restored sensitivity of STZ-treated rats to amphetamine-stimulated locomotion and also produced conditioned place preference, without affecting blood glucose and body weight changes. However, amphetamine treatment did not restore sensitivity to the behavioral effects of quinpirole, raclopride, or GHB, suggesting differential regulation of dopamine transporter activity and sensitivity of D2 receptors in hypoinsulinemic rats. Insulin replacement in STZ-treated rats normalized blood glucose and body weight changes and fully restored sensitivity to quinpirole-induced yawning, as well as to raclopride-induced catalepsy, while reducing sensitivity to GHB-induced catalepsy. Overall, these data indicate that changes in insulin status markedly affect sensitivity to the behavioral effects of dopaminergic drugs. The results underscore the importance of insulin in modulating DA neurotransmission; these effects might be especially relevant to understanding the co-morbidity of eating disorders and substance abuse.Several drugs of abuse (e.g., amphetamine and cocaine) and some drugs that are used in the clinic (e.g., haloperidol and bromocriptine) are thought to act predominantly on dopamine (DA) systems. Activity at DA D2 receptors can modulate DA neurotransmission by affecting DA synthesis, release, uptake, or neuronal activity (Zahniser and Doolen, 2001). Importantly, insulin has been shown to regulate DA signaling in the brain (Figlewicz et al., 1994(Figlewicz et al., , 1996. Insulin can cross the blood-brain barrier and act on receptors (i.e., insulin receptors, insulin-like growth factor-1 receptors) that are densely concentrated in the basal ganglia, a region richly expressing D2/D3 receptors and DA transporters (DATs) (Ciliax et al., 1995;Larson and Ariano, 1995;Schulingkamp et al., 2000;Figlewicz et al., 2003). The proximity of insulin and DA systems seems to have functional consequences. For example, rats with decreased circulating insulin showed decreased coupling of DA D2 receptors to G i/o proteins (Abbracchio et a...

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Ethanol-Induced Conditioned Place Aversion in Rats: Effect of Interstimulus Interval

Cited by 39 publications

References 46 publications

Alcohol Preference Influences the Subthalamic Nucleus Control on Motivation for Alcohol in Rats

Alcohol Preference Influences the Subthalamic Nucleus Control on Motivation for Alcohol in Rats

Effects of MDMA exposure on the conditioned place preference produced by other drugs of abuse

Insulin Replacement Restores the Behavioral Effects of Quinpirole and Raclopride in Streptozotocin-Treated Rats

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