Ethanol-induced dose dumping from sodium alginate matrix tablets: Investigation of the effects of medium viscosity and pH

Rahim, Safwan Abdel; Al-Zoubi, Nizar; Khader, Heba; Alwaraydat, Rahaf; Al-Akayleh, Faisal

doi:10.1016/j.ijpharm.2022.122568

Cited by 4 publications

(1 citation statement)

References 60 publications

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“…Modern industrial production mostly involves liquid fermentation, and culture substrates include glucose, maltose, sucrose, glutinous rice flour, and other carbon sources. The above two production methods are mostly natural; therefore, the pH of the culture medium is mostly between 7 and 7.6 [ 34 ]. During the experiment, when the culture medium was pH 7, M. purpureus colonies formed early and in high numbers, whereas the size, number, and occurrence time of the colonies were approximately the same when the culture medium was pH 6 and pH 8.…”

Section: Resultsmentioning

confidence: 99%

Inorganic Selenium Transformation into Organic Selenium by Monascus purpureus

Sun,

Dang,

Zhang

et al. 2023

Foods

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Selenium (Se) is a trace element that plays a crucial role in metabolism; a lack of selenium reduces the body’s resistance and immunity, as well as causes other physiological problems. In this study, we aim to identify favorable conditions for improving organic selenium production. The functional microbe Monascus purpureus, which is widely used in food production, was employed to optimize selenium-enriched culture conditions, and its growth mode and selenium-enriched features were investigated. Spectrophotometry, inductively coupled plasma optical emission spectrometry (ICP-OES), and HPLC (High-Performance Liquid Chromatography) were used to determine the effects of various doses of sodium selenite on the selenium content, growth, and metabolism of M. purpureus, as well as the conversion rate of organic selenium. The best culture parameters for selenium-rich M. purpureus included 7.5 mg/100 mL of selenium content in the culture medium, a pH value of 6.8, a culture temperature of 30 °C, and a rotation speed of 180 rpm. Under ideal circumstances, the mycelia had a maximum selenium concentration of approximately 239.17 mg/kg, with organic selenium accounting for 93.45%, monacoline K production reaching 70.264 mg/L, and a secondary utilization rate of external selenium of 22.99%. This study revealed a novel biological route—selenium-rich M. purpureus fermentation—for converting inorganic selenium into organic selenium.

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Section: Resultsmentioning

confidence: 99%

Inorganic Selenium Transformation into Organic Selenium by Monascus purpureus

Sun,

Dang,

Zhang

et al. 2023

Foods

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Inhibit diffusion of the small molecule drug lidocaine hydrochloride in dissolving microneedles based on a phase separation approach

Huang,

Liu,

Liu

et al. 2024

Journal of Drug Delivery Science and Technology

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Exploration of a Novel Terpolymer Nanoparticle System for the Prevention of Alcohol-Induced Dose Dumping

Chen,

Chang,

Lugtu-Pe

et al. 2024

Mol. Pharmaceutics

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Alcohol-induced dose dumping (AIDD) remains a serious challenge in the controlled delivery of high potency drugs, such as opioids, which requires extensive investigation and innovative solutions. Current technologies rely on ethanol-insoluble excipients, such as guar gum and sodium alginate, to counteract the increased solubility of hydrophobic polymeric excipients in ethanol. However, these excipients pose several shortcomings, such as high viscosity of coating dispersion, high solution temperature, rapid gelation, and heterogeneity of resulted film. In this work, we explored the application of a cross-linked terpolymer nanoparticle (TPN) as an alcohol-resistant excipient in a water-insoluble controlled release film of ethylcellulose (EC) for the prevention of AIDD. Herein, we optimized the composition of TPN using a central composite design (CCD) to minimize swelling and weight loss of TPN-EC film in the presence of 20% ethanol. The optimized TPN showed a negligible effect on the viscosity of the coating dispersion, while guar gum increased the viscosity by 76-fold. Permeability studies in a pH 1.2 media containing 0% or 40% v/v ethanol revealed that cationic drugs (propranolol HCl, diltiazem HCl, and naloxone HCl (an opioid receptor-binding model drug)) exhibited significantly lower permeability ratios (P 40% /P 0% ) than un-ionized drugs (theophylline and salicylic acid). FTIR analysis indicated an increase in ionic hydrogen bonding between TPN and the cationic drug in the presence of ethanol. These results suggest that drug−polymer−solvent interactions play an important role in alcohol-independent drug permeability through the TPN-EC film. By leveraging the drug permeability altering capability of the TPN-EC system, the release of cationic drugs in hydroethanolic media appeared to be suppressed, suggesting a promising new mechanism of alcohol resistance.

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Ethanol-induced dose dumping from sodium alginate matrix tablets: Investigation of the effects of medium viscosity and pH

Cited by 4 publications

References 60 publications

Inorganic Selenium Transformation into Organic Selenium by Monascus purpureus

Inorganic Selenium Transformation into Organic Selenium by Monascus purpureus

Inhibit diffusion of the small molecule drug lidocaine hydrochloride in dissolving microneedles based on a phase separation approach

Exploration of a Novel Terpolymer Nanoparticle System for the Prevention of Alcohol-Induced Dose Dumping

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