Ethanol pre‐exposure during adolescence or adulthood increases ethanol intake but ethanol‐induced conditioned place preference is enhanced only when pre‐exposure occurs in adolescence

Carrara-Nascimento, Priscila Fernandes; Camarini, Rosana

doi:10.1002/dev.21089

Cited by 29 publications

(29 citation statements)

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“…The present study also highlights that neural adaptations in response to repeated ethanol and stressors differ between adolescents and adults. We have demonstrated that adolescents are less sensitive to ethanol-induced sensitization than adults (Carrara-Nascimento, Griffin, Pastrello, Olive, & Camarini, 2011;Carrara-Nascimento, Olive, & Camarini, 2014;Faria et al, 2008), and here we extend this lower sensitivity also to CUS-ETOH cross-sensitization. Locomotor sensitization and crosssensitization are behavioral proxies of alcohol/stress-induced neuroadaptations, and the complexity of the brain development during adolescence may explain age differences in those behavioral responses to ethanol/stress.…”

Section: Discussionsupporting

confidence: 76%

Involvement of neuronal nitric oxide synthase in cross-sensitization between chronic unpredictable stress and ethanol in adolescent and adult mice

Santos-Rocha

Rae

Teixeira

et al. 2018

Alcohol

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a b s t r a c tThe peculiar neurochemical profile of the adolescent brain renders it differently susceptible to several stimuli, including stress and/or drug exposure. Among several stress mediators, nitric oxide (NO) has a role in stress responses. We have demonstrated that adolescent mice are less sensitive to ethanolinduced sensitization than adult mice. The present study investigated whether chronic unpredictable stress (CUS) induces behavioral sensitization to ethanol in adolescent and adult Swiss mice, and investigated the influence of Ca 2þ -dependent nitric oxide synthase (NOS) activity in the phenomenon.Adolescent and adult mice were exposed to repeated 1.8 g/kg ethanol or CUS and challenged with saline or ethanol. A neuronal nitric oxide synthase (nNOS) inhibitor, 7-nitroindazole (7NI), was administered along with ethanol and CUS to test its effects on behavioral sensitization. Both adolescent and adult mice displayed cross-sensitization between CUS and ethanol in adult mice, with adolescents showing a lower degree of sensitization than adults. nNOS inhibition by 7NI reduced both ethanol sensitization and crosssensitization. All age differences in the Ca 2þ -dependent NOS activity in the hippocampus and prefrontal cortex were in the direction of greater activity in adults than in adolescents. Adolescents showed lower sensitivity to cross-sensitization between CUS and ethanol, and the nitric oxide (NO) system seems to have a pivotal role in ethanol-induced behavioral sensitization and cross-sensitization in both adolescent and adult mice.

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Section: Discussionsupporting

confidence: 76%

Involvement of neuronal nitric oxide synthase in cross-sensitization between chronic unpredictable stress and ethanol in adolescent and adult mice

Santos-Rocha

Rae

Teixeira

et al. 2018

Alcohol

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“…This developmental effect, that drinking during adolescence leads to a different profile of behavior than drinking during adulthood, has also been shown in mice. Carrara-Nascimento, Olive & Camarini (2014) found that adolescent and adult alcohol-exposed mice consumed the same amount of alcohol after a 15-day treatment (2 g/kg injection) but only the adolescent-exposed mice showed a robust preference during the condition-place preference paradigm. These results indicate that administration of ethanol during adolescence can alter future behaviors in a different manor than when administered in adulthood.…”

Section: Discussionmentioning

confidence: 94%

“…None the less, future studies are needed to further investigating the appetitive and motivational impact of adult alcohol exposure. Previous studies have shown that pre-exposure to ethanol in adulthood increased future consumption (de la Torre, Escarabajal & Agüero, 2015; Carrara-Nascimento, Olive & Camarini, 2014). While pre-exposure increased consumption in both adolescent and young adult rats, it modestly increased the motivation to consume alcohol in the adolescent-exposed rats compared to controls.…”

Section: Discussionmentioning

confidence: 99%

Alcohol drinking during adolescence increases consumptive responses to alcohol in adulthood in Wistar rats

Amodeo

Kneiber

Wills

et al. 2017

Alcohol

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Binge drinking and the onset of alcohol use disorders usually peak during the transition between late adolescence and early adulthood, and early adolescent onset of alcohol consumption has been demonstrated to increase the risk for alcohol dependence in adulthood. In the present study we describe an animal model of early adolescent alcohol consumption where animals drink unsweetened and unflavored ethanol in high concentrations (20%). Using this model we investigated the influence of drinking on alcohol-related appetitive behavior and alcohol consumption levels in early adulthood. Further, we also sought to investigate whether differences in alcohol-related drinking behaviors were specific to exposure in adolescence versus exposure in adulthood. Male Wistar rats were given a 2-bottle choice between 20% ethanol and water in one group and between two water bottles in another group during their adolescence (Postnatal Day (PD) PD26-59) to model voluntary drinking in adolescent humans. As young adults (PD85), rats were trained in a paradigm that provided free access to 20% alcohol for 25 min after completing up to a fixed ratio (FR) 16-lever press response. A set of young adult male Wistar rats was exposed to the same paradigm using the same time course beginning at PD92. The results indicate that adolescent exposure to alcohol increased consumption of alcohol in adulthood. Furthermore, when investigating differences between adolescent high and low adolescent drinkers in adulthood, high consumers continued to drink more alcohol, had fewer FR failures, and had faster completion of FR schedules in adulthood whereas the low consumers were no different than controls. Rats exposed to ethanol in young adulthood also increased future intake but there were no differences in any other components of drinking behavior. Both adolescent- and adult-exposed rats did not exhibit an increase in lever pressing during the appetitive challenge session. These data indicate that adolescent and early adult alcohol exposure can increase consumptive aspects of drinking but that adolescent exposure may preferentially influence the motivation to drink.

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“…Ethanol exposure during adolescence can cause dramatic neurobehavioral and neurotoxicological effects compared to exposure during adulthood, as described in humans (Grant and Dawson, 1997; De Wit et al, 2000; Ehlers et al, 2006) and rodents (Crews et al, 2000; Faria et al, 2008; Walker and Ehlers, 2009; Guerri and Pascual, 2010; Soares-Simi et al, 2013; Carrara-Nascimento et al, 2014). …”

Section: Introductionmentioning

confidence: 97%

“…Drinking in the dark (DID) paradigm is considered a binge-like model since it promotes high levels of blood ethanol concentration (Rhodes et al, 2005). Another procedure to promote increase in ethanol consumption is to preexpose the animals to the drug (Lessov et al, 2001; Camarini and Hodge, 2004; Carrara-Nascimento et al, 2014). …”

Section: Introductionmentioning

confidence: 99%

Ethanol Sensitization during Adolescence or Adulthood Induces Different Patterns of Ethanol Consumption without Affecting Ethanol Metabolism

Carrara-Nascimento

Hoffmann

Contó

et al. 2017

Front. Behav. Neurosci.

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In previous study, we demonstrated that ethanol preexposure may increase ethanol consumption in both adolescent and adult mice, in a two-bottle choice model. We now questioned if ethanol exposure during adolescence results in changes of consumption pattern using a three-bottle choice procedure, considering drinking-in-the-dark and alcohol deprivation effect as strategies for ethanol consumption escalation. We also analyzed aldehyde dehydrogenase (ALDH) activity as a measurement of ethanol metabolism. Adolescent and adult Swiss mice were treated with saline (SAL) or 2.0 g/kg ethanol (EtOH) during 15 days (groups: Adolescent-SAL, Adolescent-EtOH, Adult-SAL and Adult-EtOH). Five days after the last injection, mice were exposed to the three-bottle choice protocol using sucrose fading procedure (4% + sucrose vs. 8%–15% ethanol + sucrose vs. water + sucrose) for 2 h during the dark phase. Sucrose was faded out from 8% to 0%. The protocol was composed of a 6-week acquisition period, followed by four withdrawals and reexposures. Both adolescent and adult mice exhibited ethanol behavioral sensitization, although the magnitude of sensitization in adolescents was lower than in adults. Adolescent-EtOH displayed an escalation of 4% ethanol consumption during acquisition that was not observed in Adult-EtOH. Moreover, Adult-EtOH consumed less 4% ethanol throughout all the experiment and less 15% ethanol in the last reexposure period than Adolescent-EtOH. ALDH activity varied with age, in which older mice showed higher ALDH than younger ones. Ethanol pretreatment or the pattern of consumption did not have influence on ALDH activity. Our data suggest that ethanol pretreatment during adolescence but not adulthood may influence the pattern of ethanol consumption toward an escalation in ethanol consumption at low dose, without exerting an impact on ALDH activity.

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Ethanol pre‐exposure during adolescence or adulthood increases ethanol intake but ethanol‐induced conditioned place preference is enhanced only when pre‐exposure occurs in adolescence

Cited by 29 publications

References 91 publications

Involvement of neuronal nitric oxide synthase in cross-sensitization between chronic unpredictable stress and ethanol in adolescent and adult mice

Involvement of neuronal nitric oxide synthase in cross-sensitization between chronic unpredictable stress and ethanol in adolescent and adult mice

Alcohol drinking during adolescence increases consumptive responses to alcohol in adulthood in Wistar rats

Ethanol Sensitization during Adolescence or Adulthood Induces Different Patterns of Ethanol Consumption without Affecting Ethanol Metabolism

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