Ethanol toxicity differs depending on the time of day

Vera, Luisa María; Bello, Carolina; Paredes, Juan Fernando; Carmona‐Antoñanzas, Greta; Sánchez-Vázquez, F.J.

doi:10.1371/journal.pone.0190406

Cited by 19 publications

(10 citation statements)

References 45 publications

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“…Mice with binge alcohol drinking at ZT12 had higher serum alcohol levels than ZT0, and serum LPS levels were highest when gavage was performed at ZT4 or ZT8 . Exposure of zebrafish larvae to 5% ethanol for 1 hour can be fatal, and a previous study found that mortality was highest with exposure at ZT2 and lowest at ZT18, indicating the time‐dependent effects of alcohol . Mice with albumin promoter‐driven Cre recombinase ( Alb ‐Cre mice) have Cre expression selectively in hepatocytes and hepatic stellate cells (HSCs) .…”

Section: Functional Roles and Therapeutic Potentials Of Melatonin Andmentioning

confidence: 99%

“…22 Exposure of zebrafish larvae to 5% ethanol for 1 hour can be fatal, and a previous study found that mortality was highest with exposure at ZT2 and lowest at ZT18, indicating the time-dependent effects of alcohol. 23 Mice with albumin promoter-driven Cre recombinase (Alb-Cre mice) have Cre expression selectively in hepatocytes and hepatic stellate cells (HSCs). 24 Zhang et al generated Alb-Cre-mediated liver-specific BMAL1 knockout mice and found that these mice had higher serum aminotransferase (ALT) levels and liver steatosis compared to control mice after chronic and binge alcohol feeding.…”

Section: Alcoholic Liver Diseasementioning

confidence: 99%

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Melatonin and circadian rhythms in liver diseases: Functional roles and potential therapies

Sato

Meng

Francis

et al. 2020

Journal of Pineal Research

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Circadian rhythms and clock gene expressions are regulated by the suprachiasmatic nucleus in the hypothalamus, and melatonin is produced in the pineal gland. Although the brain detects the light through retinas and regulates rhythms and melatonin secretion throughout the body, the liver has independent circadian rhythms and expressions as well as melatonin production. Previous studies indicate the association between circadian rhythms with various liver diseases, and disruption of rhythms or clock gene expression may promote liver steatosis, inflammation, or cancer development. It is well known that melatonin has strong antioxidant effects. Alcohol drinking or excess fatty acid accumulation produces reactive oxygen species and oxidative stress in the liver leading to liver injuries. Melatonin administration protects these oxidative stress‐induced liver damage and improves liver conditions. Recent studies have demonstrated that melatonin administration is not limited to antioxidant effects and it has various other effects contributing to the management of liver conditions. Accumulating evidence suggests that restoring circadian rhythms or expressions as well as melatonin supplementation may be promising therapeutic strategies for liver diseases. This review summarizes recent findings for the functional roles and therapeutic potentials of circadian rhythms and melatonin in liver diseases.

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Section: Functional Roles and Therapeutic Potentials Of Melatonin Andmentioning

confidence: 99%

Section: Alcoholic Liver Diseasementioning

confidence: 99%

Melatonin and circadian rhythms in liver diseases: Functional roles and potential therapies

Sato

Meng

Francis

et al. 2020

Journal of Pineal Research

View full text Add to dashboard Cite

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“…Moreover, some chemotherapeutic agents increase their efficacy and reduce their toxicity in cancer patients when administered, taking into account the endogenous clock time [ 2 , 25 , 26 ]. In addition, alcohol toxicity differs according to the time of intake and increases when alcohol is consumed in the morning compared to evening intake [ 27 ].…”

Section: Elementary Glossary Of Chronobiologymentioning

confidence: 99%

“…In this context, emerging evidence indicates that correct chronotherapy by synchronizing drug delivery with the endogenous physiological rhythm may be used to optimize treatment efficacy. In fact, adjusting the administration of some drugs to the time has been shown to improve their therapeutic effects and reduce off-target side effects [ 2 , 25 , 26 , 27 ]. It is more difficult to therapeutically restore a normal rhythmicity once it is disrupted.…”

Section: Interrelationship Between Disorders Of Chrono-organization and Thyroid Diseasesmentioning

confidence: 99%

Chronothyroidology: Chronobiological Aspects in Thyroid Function and Diseases

Bellastella

Maiorino

Scappaticcio

et al. 2021

Life

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Chronobiology is the scientific discipline which considers biological phenomena in relation to time, which assumes itself biological identity. Many physiological processes are cyclically regulated by intrinsic clocks and many pathological events show a circadian time-related occurrence. Even the pituitary–thyroid axis is under the control of a central clock, and the hormones of the pituitary–thyroid axis exhibit circadian, ultradian and circannual rhythmicity. This review, after describing briefly the essential principles of chronobiology, will be focused on the results of personal experiences and of other studies on this issue, paying particular attention to those regarding the thyroid implications, appearing in the literature as reviews, metanalyses, original and observational studies until 28 February 2021 and acquired from two databases (Scopus and PubMed). The first input to biological rhythms is given by a central clock located in the suprachiasmatic nucleus (SCN), which dictates the timing from its hypothalamic site to satellite clocks that contribute in a hierarchical way to regulate the physiological rhythmicity. Disruption of the rhythmic organization can favor the onset of important disorders, including thyroid diseases. Several studies on the interrelationship between thyroid function and circadian rhythmicity demonstrated that thyroid dysfunctions may affect negatively circadian organization, disrupting TSH rhythm. Conversely, alterations of clock machinery may cause important perturbations at the cellular level, which may favor thyroid dysfunctions and also cancer.

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“…In this context, recent research has revealed a daily rhythm in the effects of ethanol in zebrafish, characterized by higher mortality rates in larvae exposed to 5% ethanol at the beginning of the day (80%) than in the middle of the night (6%). In addition, behavioral effects in adults exposed to 1% ethanol were also more severe during the day, with key genes involved in ethanol detoxification in the liver showing circadian rhythmicity in continuous darkness (DD) (183).…”

Section: Time-dependent Stress Responses and Detoxification Rhythmsmentioning

confidence: 99%

Environmental Cycles, Melatonin, and Circadian Control of Stress Response in Fish

et al. 2019

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Fish have evolved a biological clock to cope with environmental cycles, so they display circadian rhythms in most physiological functions including stress response. Photoperiodic information is transduced by the pineal organ into a rhythmic secretion of melatonin, which is released into the blood circulation with high concentrations at night and low during the day. The melatonin rhythmic profile is under the control of circadian clocks in most fish (except salmonids), and it is considered as an important output of the circadian system, thus modulating most daily behavioral and physiological rhythms. Lighting conditions (intensity and spectrum) change in the underwater environment and affect fish embryo and larvae development: constant light/darkness or red lights can lead to increased malformations and mortality, whereas blue light usually results in best hatching rates and growth performance in marine fish. Many factors display daily rhythms along the hypothalamus-pituitary-interrenal (HPI) axis that controls stress response in fish, including corticotropin-releasing hormone (Crh) and its binding protein (Crhbp), proopiomelanocortin A and B (Pomca and Pomcb), and plasma cortisol, glucose, and lactate. Many of these circadian rhythms are under the control of endogenous molecular clocks, which consist of self-sustained transcriptional-translational feedback loops involving the cyclic expression of circadian clock genes ( clock, bmal, per , and cry ) which persists under constant light or darkness. Exposing fish to a stressor can result in altered rhythms of most stress indicators, such as cortisol, glucose, and lactate among others, as well as daily rhythms of most behavioral and physiological functions. In addition, crh and pomca expression profiles can be affected by other factors such as light spectrum, which strongly influence the expression profile of growth-related ( igf1a, igf2a ) genes. Additionally, the daily cycle of water temperature (warmer at day and cooler at night) is another factor that has to be considered. The response to any acute stressor is not only species dependent, but also depends on the time of the day when the stress occurs: nocturnal species show higher responses when stressed during day time, whereas diurnal fish respond stronger at night. Melatonin administration in fish has sedative effects with a reduction in locomotor activity and cortisol levels, as well as reduced liver glycogen and dopaminergic and serotonergic activities within the hypothalamus. In this paper, we are reviewing the role of environmental cycles and biological clocks on the entrainment of daily rhythms in the HPI axis and stress responses in fish.

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Ethanol toxicity differs depending on the time of day

Cited by 19 publications

References 45 publications

Melatonin and circadian rhythms in liver diseases: Functional roles and potential therapies

Melatonin and circadian rhythms in liver diseases: Functional roles and potential therapies

Chronothyroidology: Chronobiological Aspects in Thyroid Function and Diseases

Environmental Cycles, Melatonin, and Circadian Control of Stress Response in Fish

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