Ether Anesthesia

Miller, Albert H.

doi:10.1097/00000542-194709000-00003

Cited by 3 publications

(4 citation statements)

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“…The half-life of Bupivacaine is up to 8 hours [27] and the elimination half life is 4-6 hours. Half life of Bupivacaine is increased in the elderly people.…”

Section: Discussionmentioning

confidence: 99%

Efficacy of Parasternal Injection of Bupivacaine on Postopeartive Pain for Early Extubation in Patients Undergoing Coronary Artery Bypass Surgery

Rahman¹,

Siddiqi²,

Husain³

et al. 2016

JCCR

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Objectives: The aim of this study was to determine the efficacy of parasternal injection of Bupivacaine on postoperative pain for early extubation in patients undergoing coronary artery bypass grafting. Material and methods:Patients admitted throughout patient department for elective primary coronary artery bypass surgery into the surgical ward were enrolled for the study. A total of 35 patients were randomized into two groups, (Bupivacaine) group 1 13 (37.14%) and (Placebo) group 2 15 (42.85%). Patients were induced with standard anesthetic protocols. Bupivacaine injection 0.5% at 2mg per kg was diluted in 50 mls syringe with normal saline and 50mls of normal saline was used as Placebo. Identical syringes marked with a study number of patient were delivered to the operating theaters. Both the surgeon and the anesthetist were blinded of the content of the solution. At the end of the procedure the injection was infiltrated into the parasternal wound before placing the sternal wires. Patients were assessed in the intensive care unit by the anesthetist for early extubation. At the time of extubation pain intensity was measured with Visual analogue scale system and recorded.

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“…The half-life of Bupivacaine is up to 8 hours [27] and the elimination half life is 4-6 hours. Half life of Bupivacaine is increased in the elderly people.…”

Section: Discussionmentioning

confidence: 99%

Efficacy of Parasternal Injection of Bupivacaine on Postopeartive Pain for Early Extubation in Patients Undergoing Coronary Artery Bypass Surgery

Rahman¹,

Siddiqi²,

Husain³

et al. 2016

JCCR

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“…From the 298 records reviewed, a sample of 47 patients was obtained. Although halothane is typically used in the pediatric age group due to inhalation inductions (Miller, 1994), the enflurane group had the lowest mean age (17.0 years). However since the majority of the pediatric patients had to be excluded due to absence of a caffeinehalothane contracture test (CHCT), the data is skewed from what is normally used in clinical practice.…”

Section: Discussionmentioning

confidence: 99%

“…As was expected, the enflurane group was the smallest as it has been used less frequently now with the introduction of newer anesthetics (McCarthy 1994). Although there were no records that were used in the sevoflurane and desflurane group, additional data may be available for future studies as both of these agents are used very commonly now compared to other volatile anesthetics (Miller, 1994).…”

Section: Discussionmentioning

confidence: 99%

Differences in the Onset and Severity of Symptoms of Malignant Hyperthermia with Different Inhalational Anesthetics

Solberg¹

1999

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Malignant hyperthermia (MH) is an uncommon inherited disorder of skeletal muscle in which commonly used anesthetics can trigger sustained skeletal muscle hypermetabolism in patients who may have had no symptoms previously. The onset and severity of clinical symptoms of MH are variable. Non-clinical studies and case reports have identified differences in the onset and severity of symptoms with the commonly used volatile anesthetics. The purpose of this study was to identify if there is a significant difference in the onset and severity of signs and symptoms of malignant hyperthermia in those MH-susceptible patients who received the different volatile anesthetics. A comparative descriptive research design was used. A retrospective review of the database at the (USUHS) MH muscle biopsy diagnostic center was done. The data collected was used to determine if there was a difference in the onset and severity of signs and symptoms of MH episodes with halothane compared to MH episodes of four other volatile anesthetics. For each of these groups, the following variables were assessed: highest temperature, highest end-tidal carbon dioxide, time from beginning of anesthetic until onset of first MH symptom, time of onset of anesthesia until initial treatment for MH, and the incidence of masseter spasm. Based on results of this study, there was no significant difference among the groups. As much of the pediatric data was excluded, the results may have been skewed. Further studies examining these differences between volatile anesthetics would be extremely valuable in understanding the pathophysiology of malignant hyperthermia.

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“…Beta-adrenergic blocking agents have very similar chemical structures to topical anesthetics including benzene ring. Local anesthetics inhibit sodium flux by acting on specific receptors called 'sodium channels' [5] and prevent depolarization. It is not unreasonable to assume that the chemical structure of local anesthetics and betablockers both indicate antimicrobial activity and anesthetic action.…”

Section: Discussionmentioning

confidence: 99%

Antimicrobial Activity of Topical Beta-Adrenergic Blocking Agents

Takahashi

Murota²,

Sutoh³

1983

Ophthalmic Res

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Three topical beta-adrenergic blocking agents without preservatives were tested for their ability to inhibit the growth of five microorganisms in vitro. Timolol maleate and befunolol hydrochloride showed no antimicrobial activity; however, bupranolol hydrochloride inhibited microbial growth. The minimum inhibitory concentration of bupranolol hydrochloride was 0.1% for Bacillus subtilis and 0.05% for Staphylococcus aureus and Escherichia coli

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Ether Anesthesia

Cited by 3 publications

References 0 publications

Efficacy of Parasternal Injection of Bupivacaine on Postopeartive Pain for Early Extubation in Patients Undergoing Coronary Artery Bypass Surgery

Efficacy of Parasternal Injection of Bupivacaine on Postopeartive Pain for Early Extubation in Patients Undergoing Coronary Artery Bypass Surgery

Differences in the Onset and Severity of Symptoms of Malignant Hyperthermia with Different Inhalational Anesthetics

Antimicrobial Activity of Topical Beta-Adrenergic Blocking Agents

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