Background: The novel coronavirus disease (COVID-19) is disseminating rapidly, increasing stress and challenges for health care professionals around the world. This study aims to discover the psychosocial challenges faced by female health care professionals (HCPs) treating COVID-19 patients in Pakistan.Methods: Using an empirical phenomenological methodology, semi-structured telephone-based qualitative interviews were taken from 22 female HCPs who were providing their expertise for COVID-19 patients in tertiary level hospitals of Lahore, Pakistan. Purposive sampling has been used for recruitment. The interviews were taken from July 20 to August 20, 2020. The interviews were analysed using thematic analysis.Results: This study discovered the psychosocial challenges faced by female HCPs serving COVID-19 patients. Five themes have been observed in the interviews: psychological concerns of HCPs while treating COVID-19 patients; feelings towards COVID-19 patients; confidence in government, administration and self-reflection; challenges as female HCPs and coping strategies; and finally, future concerns and recommendations. Many of these themes have also been linked with cultural issues, making the results specific for Pakistan.Conclusions: During the COVID-19 pandemic, female front-line HCPs have faced immense psychosocial pressure, starting from unsupportive family norms to unwelcoming working environment and insensitive hospital administration. Moreover, rumours among general public, lack of proper training, missing incentives and improper system surveillance had increased the anxiety and stress among HCPs. Hence, legislators are advised to take appropriate actions countrywide in order to improve the still on-going challenges and to support female HCPs in their working environment.