Ethnic and geographic variations in the epidemiology of childhood fractures in the United Kingdom

Moon, Rebecca J; Harvey, Nicholas C.; Curtis, Elizabeth M; Vries, Frank de; Staa, Tjeerd van; Cooper, Cyrus

doi:10.1016/j.bone.2016.01.015

Cited by 78 publications

(61 citation statements)

References 49 publications

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“…This predominance is attributed to biological and social active and risk taking behaviour among males with increasing age. [9][10][11] The majority of children belong to Malay ethnicity similar to study by Asim et al 7 The majority of fractures occurred at home 148 (40.1%) which was similar results with a further study. 6,9 In the home environment, among infants and toddlers, most fractures were related to falls from cots, beds, tripping over furniture, or from heights.…”

Section: Discussionsupporting

confidence: 80%

Epidemiological characteristics of pediatrics fracture at tertiary care hospital, Malaysia

Bhardwaj

Sivapatha

Yusof

et al. 2017

Int J Contemp Pediatr

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Background: Childhood fracture resulting from trauma has become a major cause of morbidity, disability and socio-economic burden worldwide as well as Malaysia. So, we aim to assess the various epidemiological parameters that influence the etiology of fracture among the pediatrics population at Melaka, Malaysia and to establish data to develop effective preventive strategies.Methods: A hospital based cross sectional study was conducted at Melaka General Hospital, Melaka from January 2013 to December 2013. There were total 369 pediatrics fracture cases admitted to MGH during study period.Results: Among 369 cases, (64.2%) of cases were found among school going age followed by (30.9%) among toddler and (4.9%) of cases among infant. (69.6%) of cases were males and most of them were Malay (87.3%) The incidents occurred mostly in evening around 6pm most significantly in between 10 am to 11 pm. The most common place of injury was at home (40.4%) and fall (77.2%) is the most common mechanism of injury. Left upper extremity involved majority of facture and common site of injuries were around elbow. Epiphyseal injuries account for (9.4 %) and among them distal radius epiphyseal injury account for (68.6 %) which is statically significant (P=0.00).Conclusions: We concluded that the common mechanism of fracture was fall, (low energy trauma) occurred at home involving left upper extremity around elbow. We believed that community based education by health care professionals and paediatricians on prevention strategies can be instrumental in reducing the incidence of paediatric fractures.

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Section: Discussionsupporting

confidence: 80%

Epidemiological characteristics of pediatrics fracture at tertiary care hospital, Malaysia

Bhardwaj

Sivapatha

Yusof

et al. 2017

Int J Contemp Pediatr

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“…The occurrence of fracture in the forearms, hands, and feet of children is high, particularly in the ankles, with a global incident rate of 187 per 100,000 people. However, incidence rates vary among countries, ages, sexes and sites of injury (1)(2)(3). Due to the specific characteristics of children's bones, delayed and/or improper treatment of ankle fracture in children may cause bone deformity and disability (4,5).…”

Section: Introductionmentioning

confidence: 99%

N‑methyl pyrrolidone promotes ankle fracture healing by inhibiting inflammation via suppression of the mitogen‑activated protein kinase signaling pathway

et al. 2018

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Abstract. N-methyl pyrrolidone (NMP), a small bioactive molecule, has the potential to stimulate bone formation and inhibit osteoclast differentiation. The aim of the present study was to investigate the effect of NMP on the inflammatory response and underlying molecular mechanisms in MG-63 cells. The mRNA and protein expression of cytokines from peripheral blood in children with or without ankle fracture were determined by reverse transcription-quantitative polymerase chain reaction (RT-qPCR) and ELISA, respectively. MG-63 cells were pre-treated with/without NMP and stimulated with 1 µM bradykinin (BK). The production of cytokines from MG-63 cells was assessed by western blotting and RT-qPCR. The expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) mRNA and protein were measured using western blotting and/or RT-qPCR. Western blotting was used to examine the activation level of mitogen activated protein kinase. Compared with healthy children, levels of tumor necrosis factor (TNF-α), interleukin (IL)-1β and IL-6 mRNA and protein were upregulated in children with ankle fracture. NMP treatment did not induce cytotoxicity in MG-63 cells. The BK-induced upregulation of TNF-α, IL-1β, IL-6, iNOS and COX-2 mRNA and protein was reversed in a dose-dependent manner by NMP. Furthermore, NMP downregulated the activation of c-Jun NH2-terminal kinase and p38 pathways, but not the extracellular signal-related kinase pathway. Therefore, the results of the current study demonstrate that NMP inhibits inflammation dependent on the mitogen-activated protein kinase pathway in MG-63 cells, indicating that it may be beneficial in the healing of fractures.

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“…1,2 Different countries with different culture, and daily activities presented with different patterns of fractures. [3][4][5][6][7][8] Some specific fracture sites had an increasing incidence in pediatric patients, 9,10 but data on the patterns and epidemiologic trends of traumatic facial fractures in China are scarce. Compared with facial fractures occurring in adults, traumatic facial fractures in children and adolescents are relatively uncommon.…”

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confidence: 99%

Traumatic Facial Fractures in Children and Adolescents

Wang

Song

Ren

et al. 2018

Journal of Craniofacial Surgery

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This study showed a retrospective analysis of the incidence and pattern of traumatic facial fractures in a pediatric and adolescent population ( 18 years old) in China. The authors retrospectively reviewed 154 children and adolescent who had traumatic facial fractures and who were admitted to our university-affiliated hospitals from 2005 to 2010. This study enrolled 109 males and 45 females aged 11.9 AE 5.2 years old. The incidence peaked around the periods of 12 to 18 years in the male, 6 and 16 to 18 years in the female. The most common etiologies were motor vehicle collisions (MVCs) (60, 39.0%), followed by high fall (40, 26.0%), low fall (32, 20.8%). The most common fracture sites were mandible (78, 50.6%) and nose (33, 21.4%), followed by orbit (31, 20.1%). A total of 35 (22.7%) patients suffered neurological deficit. The patients in the 12 to 18 age range group accounted for the largest proportion of 54.5%. Fracture incidence showed peaks between the hours of 12:00 to 16:00 PM (33.7%), during the autumn season (30.5%) and on Friday to Sunday (50.0%). The most common etiology and fracture site were MVCs and mandible, respectively. Etiologies and patterns of traumatic facial fractures vary with age. Continued efforts toward injury prevention of traumatic facial fracture among the children and adolescents are warranted.

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Ethnic and geographic variations in the epidemiology of childhood fractures in the United Kingdom

Cited by 78 publications

References 49 publications

Epidemiological characteristics of pediatrics fracture at tertiary care hospital, Malaysia

Epidemiological characteristics of pediatrics fracture at tertiary care hospital, Malaysia

N‑methyl pyrrolidone promotes ankle fracture healing by inhibiting inflammation via suppression of the mitogen‑activated protein kinase signaling pathway

Traumatic Facial Fractures in Children and Adolescents

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