Ethnic Difference in Lipid Profiles

Zhang, Lei; Qiao, Qing; Dong, Yanhu

doi:10.5772/27915

Cited by 4 publications

(3 citation statements)

References 156 publications

(137 reference statements)

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“…The prevalence of dyslipidaemia varies between different countries depending on the population studied, geographic location, socioeconomic development, gender, the presence of metabolic disorders and genetic factors [13]. Additionally, different diagnostic criteria are used to define dyslipidaemia, which can lead to marked variations in the prevalence of dyslipidaemia reported in different studies [8].…”

Section: Prevalence Of Dyslipidaemia Worldwidementioning

confidence: 99%

Dyslipidaemia in the Middle East: Current status and a call for action

Al-Rasadi

Almahmeed²,

AlHabib

et al. 2016

Atherosclerosis

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The increase in the cardiovascular disease (CVD)-associated mortality rate in the Middle East (ME) is among the highest in the world. The aim of this article is to review the current prevalence of dyslipidaemia and known gaps in its management in the ME region, and to propose initiatives to address the burden of dyslipidaemia. Published literature on the epidemiology of dyslipidaemia in the ME region was presented and discussed at an expert meeting that provided the basis of this review article. The high prevalence of metabolic syndrome, diabetes, familial hypercholesterolaemia (FH) and consanguineous marriages, in the ME region, results in a pattern of dyslipidaemia (low high-density lipoprotein cholesterol and high triglycerides) that is different from many other regions of the world. Early prevention and control of dyslipidaemia is of paramount importance to reduce the risk of developing CVD. Education of the public and healthcare professionals and developing preventive programs, FH registries and regional guidelines on dyslipidaemia are the keys to dyslipidaemia management in the ME region.

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Section: Prevalence Of Dyslipidaemia Worldwidementioning

confidence: 99%

Dyslipidaemia in the Middle East: Current status and a call for action

Al-Rasadi

Almahmeed²,

AlHabib

et al. 2016

Atherosclerosis

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“…Dyslipidemia prevalence varies among countries depending on the ethnic population studied, geographical location, socioeconomic status, gender, and the occurrence of metabolic disorders and genetic factors (Zhang et al, 2012 ). The proportion of dyslipidemic subjects in our study is 29.3%.…”

Section: Discussionmentioning

confidence: 99%

Association of single nucleotide polymorphisms with dyslipidemia and risk of metabolic disorders in the State of Qatar

Alsharshani

Velayutham

Samara

et al. 2023

Molec Gen & Gen Med

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BackgroundDyslipidemia is recognized as one of the risk factors of cardiovascular diseases (CVDs), type 2 diabetes mellitus (T2DM), and non‐alcoholic fatty liver disease (NAFLD).ObjectiveThe study aimed to investigate the association between selected single nucleotide polymorphisms (SNPs) with dyslipidemia and increased susceptibility risks of CVD, NAFLD, and/or T2DM in dyslipidemia patients in comparison with healthy control individuals from the Qatar genome project.MethodsA community‐based cross‐sectional study was conducted among 2933 adults (859 dyslipidemia patients and 2074 healthy control individuals) from April to December 2021 to investigate the association between 331 selected SNPs with dyslipidemia and increased susceptibility risks of CVD, NAFLD and/or T2DM, and covariates.ResultsThe genotypic frequencies of six SNPs were found to be significantly different in dyslipidemia patients subjects compared to the control group among males and females. In males, three SNPs were found to be significant, the rs11172113 in over‐dominant model, the rs646776 in recessive and over‐dominant models, and the rs1111875 in dominant model. On the other hand, two SNPs were found to be significant in females, including rs2954029 in recessive model, and rs1801251 in dominant and recessive models. The rs17514846 SNP was found for dominant and over‐dominant models among males and only the dominant model for females. We found that the six SNPs linked to gender type had an influence in relation to disease susceptibility. When controlling for the four covariates (gender, obesity, hypertension, and diabetes), the difference between dyslipidemia and the control group remained significant for the six variants. Finally, males were three times more likely to have dyslipidemia in comparison with females, hypertension was two times more likely to be present in the dyslipidemia group, and diabetes was six times more likely to be in the dyslipidemia group.ConclusionThe current investigation provides evidence of association for a common SNP to coronary heart disease and suggests a sex‐dependent effect and encourage potential therapeutic applications.

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“…Dislipidemi prevalansı popülasyonların özelliklerine, coğrafi yerleşime, sosyoekonomik duruma, cinsiyete, metabolik ve genetik faktörlere bağlı olarak farklı ülkelerde değişkenlik göstermektedir. 13 Bu konudaki çalışmaların büyük kısmı "Adult Treatment Panel III of the National Cholesterol Education Program (NCEP ATP III)" tarafından tarif edilen kriterlere dayanmaktadır (total kolesterol ≥240 mg/dL, trigliseridler >200 mg/dL, LDL-kolesterol >160 mg/dL ve HDL-kolesterol erkekte <40 mg/dL, kadında <50 mg/dL). 14 1999-2002 yılları arasında Amerika Birleşik Devletleri (ABD)'nde yürütülen "National Health and Nutrition Examination Survey (NHANES)" çalışması, dislipidemi prevalansını %52,9 olarak rapor etmiştir.…”

Section: Discussionunclassified