Ethnic Differences in Insulin Sensitivity and β-Cell Function in Premenopausal or Early Perimenopausal Women Without Diabetes

Torréns, Javier I.; Skurnick, Joan; Davidow, Amy L.; Korenman, Stanley G.; Santoro, Nanette; Soto-Greene, Maria; Lasser, Norman L.; Weiss, Gerson

doi:10.2337/diacare.27.2.354

Cited by 150 publications

(112 citation statements)

References 44 publications

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“…Previous multiethnic cohort studies have reported the ethnic differences in insulin sensitivity and b-cell function (30). In the present study, the BMI of the subjects was relatively low in comparison with those in above studies, which may contribute to insignificant correlation between osteocalcin and HOMA-IR.…”

Section: Discussioncontrasting

confidence: 48%

Serum osteocalcin concentrations in relation to glucose and lipid metabolism in Chinese individuals

Zhou¹,

Ma²,

Li³

et al. 2009

European Journal of Endocrinology

176

128

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Objectives: Osteocalcin, a bone-derived protein, has recently been reported to affect energy metabolism. We investigated the relationship between serum osteocalcin and parameters of adiposity, glucose tolerance, and lipid profile in Chinese subjects. Methods: Serum osteocalcin was measured by electrochemiluminescence immunoassay in 254 men (128 with newly diagnosed type 2 diabetes mellitus (T2DM) and 126 with normal glucose tolerance (NGT)), 66 premenopausal women (33 with T2DM and 33 with NGT) as well as 180 postmenopausal women (92 with T2DM and 88 with NGT). Their associations with parameters of adiposity, glucose tolerance, and lipid profile were examined. Results: Serum osteocalcin concentrations in diabetic patients were significantly lower than those in NGT subjects after adjusted for age, gender, and body mass index (PZ0.003). Postmenopausal women had higher osteocalcin concentrations than premenopausal women and men (both P!0.001). Multiple stepwise regression analysis showed that age, %fat, high-density lipoprotein cholesterol, fasting plasma glucose, and fasting serum insulin were independently associated with osteocalcin in men (P!0.05). Age and HbA1c were independently correlated with osteocalcin in postmenopausal women. Besides age and HbA1c, serum triglyceride was also an independent factor influencing osteocalcin in premenopausal women. In addition, osteocalcin was also positively associated with homeostasis model assessment of b-cell function. Furthermore, multiple logistic regression analysis demonstrated that osteocalcin was independently associated with T2DM. Conclusions: Serum osteocalcin was closely associated with not only fat and glucose metabolism but also with lipid metabolism.

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Section: Discussioncontrasting

confidence: 48%

Serum osteocalcin concentrations in relation to glucose and lipid metabolism in Chinese individuals

Zhou¹,

Ma²,

Li³

et al. 2009

European Journal of Endocrinology

176

128

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“…In particular, Asians are at risk for type 2 diabetes at a lower level of obesity, partly due to their increased predisposition to visceral adiposity (29) and reduced pancreatic ␤-cell function (30). In the metaanalyses, TCF7L2 rs7903146 showed the strongest effect (OR 1.44) in both Europeans and Asians.…”

Section: Discussionmentioning

confidence: 92%

Implication of Genetic Variants Near TCF7L2, SLC30A8, HHEX, CDKAL1, CDKN2A/B, IGF2BP2, and FTO in Type 2 Diabetes and Obesity in 6,719 Asians

et al. 2008

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OBJECTIVE— Recent genome-wide association studies have identified six novel genes for type 2 diabetes and obesity and confirmed TCF7L2 as the major type 2 diabetes gene to date in Europeans. However, the implications of these genes in Asians are unclear. RESEARCH DESIGN AND METHODS— We studied 13 associated single nucleotide polymorphisms from these genes in 3,041 patients with type 2 diabetes and 3,678 control subjects of Asian ancestry from Hong Kong and Korea. RESULTS— We confirmed the associations of TCF7L2 , SLC30A8 , HHEX , CDKAL1 , CDKN2A / CDKN2B , IGF2BP2 , and FTO with risk for type 2 diabetes, with odds ratios ranging from 1.13 to 1.35 (1.3 × 10 −12 < P unadjusted < 0.016). In addition, the A allele of rs8050136 at FTO was associated with increased BMI in the control subjects ( P unadjusted = 0.008). However, we did not observe significant association of any genetic variants with surrogate measures of insulin secretion or insulin sensitivity indexes in a subset of 2,662 control subjects. Compared with subjects carrying zero, one, or two risk alleles, each additional risk allele was associated with 17% increased risk, and there was an up to 3.3-fold increased risk for type 2 diabetes in those carrying eight or more risk alleles. Despite most of the effect sizes being similar between Asians and Europeans in the meta-analyses, the ethnic differences in risk allele frequencies in most of these genes lead to variable attributable risks in these two populations. CONCLUSIONS— Our findings support the important but differential contribution of these genetic variants to type 2 diabetes and obesity in Asians compared with Europeans.

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“…However, an association between G6PC2 SNPs and type 2 diabetes was not observed in Europids. It is unclear whether ethnic differences in beta cell function, such as those suggested between Asian populations and populations of European descent in several studies [22,23], played a role in the effect of G6PC2 variants.…”

Section: Discussionmentioning

confidence: 99%

A genetic variant of G6PC2 is associated with type 2 diabetes and fasting plasma glucose level in the Chinese population

Zhang

Wang

et al. 2008

Diabetologia

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Aims/hypothesis Single nucleotide polymorphisms (SNPs) in G6PC2 have been reported to be associated with fasting plasma glucose level in several populations of European descent. However, whether G6PC2 variants have a similar effect in other ethnic groups is unknown. The aim of this study was to investigate the effect of common variants of G6PC2 on type 2 diabetes and related clinical features in a Chinese population. Methods We selected four SNPs, rs13387347, rs2232316, rs492594 and rs16856187, tagging all the common variants spanning the G6PC2 gene (r 2 ≥0.8) based on HapMap Chinese data, and genotyped them in a group of 3,676 Shanghai Chinese individuals, comprising 1,876 cases and 1,800 controls. Results Three SNPs were nominally associated with type 2 diabetes, with rs16856187 showing the strongest evidence for association (p=0.0009, empirical p=0.0047). Further conditional analysis revealed that the association signal arose from an individual SNP, rs16856187. This SNP was also associated with fasting plasma glucose level in participants with normal glucose regulation (p=0.0002), with the fasting plasma glucose level observed to increase by 0.067 mmol/l with each copy of the rare C allele. Conclusions/interpretation In this study we identified a novel risk-conferring G6PC2 SNP for type 2 diabetes in a Chinese population and confirmed the previous finding that G6PC2 variants are associated with fasting plasma glucose concentration.

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Ethnic Differences in Insulin Sensitivity and β-Cell Function in Premenopausal or Early Perimenopausal Women Without Diabetes

Cited by 150 publications

References 44 publications

Serum osteocalcin concentrations in relation to glucose and lipid metabolism in Chinese individuals

Serum osteocalcin concentrations in relation to glucose and lipid metabolism in Chinese individuals

Implication of Genetic Variants Near TCF7L2, SLC30A8, HHEX, CDKAL1, CDKN2A/B, IGF2BP2, and FTO in Type 2 Diabetes and Obesity in 6,719 Asians

A genetic variant of G6PC2 is associated with type 2 diabetes and fasting plasma glucose level in the Chinese population

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