Ethnic/Race Diversity and Diabetic Kidney Disease

Muthuppalaniappan, Vasantha Muthu; Yaqoob, Muhammad

doi:10.3390/jcm4081561

Cited by 21 publications

(7 citation statements)

References 12 publications

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“…Renal effects of dapagliflozin treatment are of particular interest because SGLT2 is expressed almost exclusively in the kidney. Asian patients with T2DM have been noted to be particularly susceptible to kidney disease . Overall, there were no clinically meaningful changes in eGFR in the present analysis.…”

Section: Discussioncontrasting

confidence: 62%

Efficacy and safety of dapagliflozin in Asian patients: A pooled analysis

Yang

Zhou

et al. 2016

Journal of Diabetes

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Section: Discussioncontrasting

confidence: 62%

Efficacy and safety of dapagliflozin in Asian patients: A pooled analysis

Yang

Zhou

et al. 2016

Journal of Diabetes

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“…A number of studies indicate that the risk of the development and progression of diabetic nephropathy varies among different populations . The incidence of ESRD attributable to both Type 1 diabetes (T1DM) and T2DM is higher among South Asian than white European people .…”

Section: Introductionmentioning

confidence: 99%

“…9 A number of studies indicate that the risk of the development and progression of diabetic nephropathy varies among different populations. 8,10,11 The incidence of ESRD attributable to both Type 1 diabetes (T1DM) and T2DM is higher among South Asian than white European people. 12,13 The literature on diabetic nephropathy in ethnic groups, however, is sparse and varied and it is not clear whether progression or higher levels of urine albumin excretion influence similar rates of estimated glomerular filtration rate (eGFR) decline among different ethnic populations, despite similar competing risks, and therefore may impact rates of prevalence of ESRD.…”

Section: Introductionmentioning

confidence: 99%

Prevalence and progression of diabetic nephropathy in South Asian, white European and African Caribbean people with type 2 diabetes: A systematic review and meta‐analysis

Jadawji

Crasto

Gillies

et al. 2018

Diabetes Obesity Metabolism

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Aims To conduct a systematic review and meta‐analysis of published observational evidence to assess the difference in the prevalence and progression of diabetic nephropathy, and the development of end‐stage renal disease (ESRD) in people from three different ethnic groups with type 2 diabetes (T2DM). Materials and methods Relevant studies were identified in a literature search of MEDLINE, EMBASE and reference lists of relevant studies published up to May 2018. We decided a priori that there were no differences in the prevalence and progression of diabetic nephropathy, and the development of ESRD in the three ethnicities with T2DM. Pooled relative risks of microalbuminuria by ethnicity were estimated by fitting three random effects meta‐analyses models. A narrative synthesis of the nephropathy progression in the studies was carried out. The review was registered in PROSPERO (CRD42018107350). Results Thirty‐two studies with data on 153 827 unique participants were eligible for inclusion in the review. The pooled prevalence ratio of microalbuminuria in South Asian compared with white European participants was 1.14 (95% confidence interval [CI] 0.99, 1.32; P = 0.065), while for African Caribbean vs South Asian participants the pooled prevalence ratio was 1.08 (95% CI 0.93, 1.24; P = 0.327). Results for renal decline were inconsistent, with preponderance towards a high rate of disease progression in South Asian compared with white participants. The estimated pooled incidence rate ratio (IRR) for ESRD was significantly higher in African Caribbean vs white European participants: 2.75 (95% CI 2.01, 3.48; P < 0.001). Conclusion The results of this review did not show a significant link between ethnicity (South Asian, white European and African Caribbean) and the prevalence of microalbuminuria; however, the IRR for ESRD in African Caribbean compared with white European participants was significantly higher. Further research is needed to explore the potential non‐albuminuric pathways of progression to ESRD.

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“…However, there is a rising body of evidence suggesting that individuals of certain ethnics and racial origins have more susceptibility to develop diabetes and her complications macro and microvascular such renal dysfunction, as described in the present study. Specially, evidence identified that patients with proteinuria and particularly those of ethnicity/race, from south Asia and black people present high risk to renal dysfunction and can be benefited with additional monitoring in a specialized clinic (20) .…”

Section: Discussionmentioning

confidence: 99%

Influence of variation of the serum creatinine on outcomes of patient with acute kidney injury

2018

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Objective: to identify the influence of variations on serum creatinine on outcomes of patients with acute kidney failure. Methods: observational and prospective study. Eighty-five patients which evolved with renal impairment composed the sample. The data was extracted from medical records and reported in a questionnaire created previously. It was considered values p≤0.05 as significant. Results: most of patients were male gender (51.8%) and elder (66±14 years). The reduction of kidney function occurred in different graduation, considering that 35.3% evolved with risk to kidney injury (stage 1) and lower percentage (14.1%) was more severely affected (stage 2 and 3), respectively. During follow-up, the clearance creatinine progressively increased showing recovery of kidney function. Patients with renal injury or failure (stage 2 or 3) evolved more frequently to death (p=0,027). Conclusion: variations on serum creatinine may exacerbate the patient outcomes over hospitalization period. Descriptors: Acute Kidney Injury; Creatinine; Mortality. Objetivo: identificar a influência de variações na creatinina sérica sobre o desfecho dos pacientes com lesão renal aguda. Métodos: estudo observacional prospectivo. A amostra foi composta de 85 pacientes que evoluíram com comprometimento renal. Os dados foram extraídos do prontuário e registrados em questionário construído previamente. Valores com p≤0,05 foram considerados significativos. Resultados: a maioria dos pacientes era do sexo masculino (51,8%) e idosos (66±14 anos). A redução da função renal ocorreu em graduações diferentes, haja vista que 35,3% evoluiu com risco para lesão renal (estágio 1) e um menor percentual (14,1%) foi acometido mais gravemente (estágios 2 e 3), respectivamente. O clearance de creatinina aumentou progressivamente revelando recuperação da função renal ao longo do acompanhamento. Pacientes com lesão ou falência renal (estágios 2 ou 3) evoluíram mais frequentemente ao óbito (p=0,027). Conclusão: variações na creatinina sérica podem agravar o desfecho do paciente ao longo do período de internação. Descritores: Lesão Renal Aguda; Creatinina; Mortalidade.

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Ethnic/Race Diversity and Diabetic Kidney Disease

Cited by 21 publications

References 12 publications

Efficacy and safety of dapagliflozin in Asian patients: A pooled analysis

Efficacy and safety of dapagliflozin in Asian patients: A pooled analysis

Prevalence and progression of diabetic nephropathy in South Asian, white European and African Caribbean people with type 2 diabetes: A systematic review and meta‐analysis

Influence of variation of the serum creatinine on outcomes of patient with acute kidney injury

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