Ethnicity and route of HCV infection can influence the associations of HLA with viral clearance in an ethnically heterogeneous population

Almeida, Bruno; Silva, G. M. Fabrício; Silva, P. M. da; Pérez, Ramón; Figueiredo, Fábio P.; Pôrto, Luís Cristóvão

doi:10.1111/j.1365-2893.2010.01429.x

Cited by 11 publications

(6 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Another possible explanation could be a difference in the route of HCV transmission. Several previous studies have suggested that the route of contamination may influence the relationship between some HLA alleles and viral clearance, and that there might be an additional factor responsible for the large variation of the results in studies of HLA and HCV clearance [Harris et al, ; de Almedia et al, ]. The thalassemia patients whom participated in the present study had received a high infectious dose of virus during blood transfusion.…”

Section: Discussionmentioning

confidence: 79%

“…The association of HLA class II alleles with HCV outcome among various ethnic populations in different geographical regions of the world has been reported. However, the results have been remarkably variable [Azocar et al, ; Ksiaa et al, ; Singh et al, ; de Almedia et al, ]. For example, Ksiaa et al [] reported that while DRB1*08 was associated with HCV clearance, DRB1*15 seemed to be a risk marker for viral persistence in the Tunisian patients.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Association of HLA class II alleles with hepatitis C virus clearance and persistence in thalassemia patients from Iran

et al. 2015

View full text Add to dashboard Cite

There is no published data on association of HLA class II alleles with clearance or persistence after acute hepatitis C virus (HCV) infection in patients from Iran. HLA DRB1, DQA1, and DQB1 alleles were determined using polymerase chain reaction amplification with sequence specific primers (PCR-SSP) on a total of 117 thalassemia patients (63 with chronic infection, and 54 with viral clearance) and 120 healthy controls. HLA-DRB1*0301 and DQA1*0501 alleles were found significantly present in patients with HCV clearance compared to those with chronic infection (P = 0.03 and P = 0.0007, respectively). By contrast, DRB1*0701, DQA1*0201, and DQB1*0602 alleles occurred significantly in those with chronic infection compared to those with viral clearance (P = 0.004, P = 0.007, and P = 0.02, respectively). As compared to the controls, DRB1*0301, DRB1*11, DQA1*0501, and DQB1*0301 alleles showed a significant decrease in chronic patients (P = 0.002, P = 0.001, P = 0.0001, and P = 0.0004, respectively). Furthermore, the haplotype frequencies of DRB1*0301, DQA1*0501, DQB1*0201, and DRB1*1101, DQA1*0501, DQB1*0301 were found significantly higher (P = 0.004 and P = 0.04, respectively) in patients with HCV clearance than those with chronic infection. By contrast, the haplotype DRB1*0701, DQA1*0201, DQB1*0201 occurred more frequently (P = 0.02) in those with chronic infection compared with those with viral clearance. These findings suggest that particular HLA alleles and related haplotypes may have an influence on the outcome of HCV infection among the Iranian patients. Some of the HLA alleles found in the Iranian patients are different from those reported elsewhere, suggesting that the immunogenetic makeup for HCV clearance or persistence may vary based on the ethnicity.

show abstract

Section: Discussionmentioning

confidence: 79%

Section: Introductionmentioning

confidence: 99%

Association of HLA class II alleles with hepatitis C virus clearance and persistence in thalassemia patients from Iran

et al. 2015

View full text Add to dashboard Cite

show abstract

“…We found no difference in the IL28B polymorphism between the CHC and SVC groups, while the other studies failed to provide such information. Second, the transmission route and the exposure dose of HCV also play an important role on the spontaneous clearance . For our subjects, the transmission route was uniform (i.e., paid plasma donors); they were infected through high‐dose exposure, whereas in other studies the transmission route and the exposure dose were heterogeneous.…”

Section: Discussionmentioning

confidence: 92%

Hepatitis C Virus Genotype Analyses in Chronic Hepatitis C Patients and Individuals With Spontaneous Virus Clearance Using a Newly Developed Serotyping Assay

Yang

Xiaoming

Xiu

et al. 2016

Clinical Laboratory Analysis

View full text Add to dashboard Cite

Background: We developed a novel HCV serotyping assay and detected the genotypes in chronic hepatitis C (CHC) patients and individuals with spontaneous viral clearance (SVC). Methods: Nine hundred and ninety-seven patients were enrolled in a previous study; their samples were genotyped originally using the molecular assays. Among them, 190 patients achieved sustained virological response; the post-treatment samples were also serotyped. Moreover, 326 samples from followup cohorts were serotyped, among whom 66 were from SVC individuals, and 260 from CHC patients. Results: Nine hundred and fifty-eight out of 997 samples were available for serotyping, among which 29 samples generated indeterminate serotyping results. The consistency between the genotyping and serotyping assays was 91.50% (850/929). The specificity and sensitivity were 98.45% and 88.77% for genotype 1, 96.42% and 93.97% for genotype 2, and 94.15% and 80.52% for non-genotype 1 or 2. However, only 41 of 60 genotype-6 samples were correctly serotyped. Little difference was found in the 190 paired serotyping results. No difference existed in the genotype distribution between the SVC and CHC groups (P = 0.08). Conclusions: The assay provides an accurate alternative for determining HCV genotypes, whereas it is not recommended for detecting genotype 6. Furthermore, it facilitates identifying the genotypes in SVC individuals. HCV genotype has little impact on SVC.

show abstract

“… 38 In fact, we previously reported the influence of ethnicity on the association between human leukocyte antigens and spontaneous viral clearance of HCV. 39 …”

Section: Discussionmentioning

confidence: 99%

Association of cytokine gene polymorphisms with hepatitis C virus infection in a population from Rio de Janeiro, Brazil

Fabricio-Silva¹,

Poschetzky²,

Perez³

et al. 2015

HMER

View full text Add to dashboard Cite

BackgroundThe host immune response is an important indicator of the outcome of hepatitis C virus (HCV) infection and disease progression. The aim of this study was to explore cytokine gene polymorphisms as a candidate for susceptibility to persistent HCV infection or HCV spontaneous clearance in a population from Rio de Janeiro, Brazil.MethodsGenetic polymorphisms in the cytokines, tumor necrosis factor-alpha (−308), transforming growth factor-beta 1 (codons 10 and 25), interleukin-10 (IL-10; −1082 and −592), IL-6 (−174), and interferon-gamma (+874) were analyzed by polymerase chain reaction sequence-specific primers in 245 patients with chronic hepatitis C (CHC), 41 spontaneous recovery (SR) patients, and 189 healthy volunteers. Further, polymorphisms in IL-28B (rs12979860, rs12980275, and rs8099917) were assessed by real-time polymerase chain reaction in all groups.ResultsThe IL-28B rs12979860 CC and rs12980275 AA genotypes were significantly associated with SR of HCV infection and response to therapy, whereas the C allele of IL-6 (−174) was associated with protection to CHC. A multivariate analysis showed that the male sex and IL-28B rs12979860 CT and TT and transforming growth factor-beta 1 (codon 10) TC genotypes were factors associated with CHC. Additionally, IL-6 (−174) C allele was increased in SR patients compared with patients with CHC.ConclusionIL-28B polymorphisms are associated with spontaneous clearance of HCV and response to therapy in a Brazilian population. Also, IL-6 (−174) C allele is involved in SR and decreased inflammation scores.

show abstract

Ethnicity and route of HCV infection can influence the associations of HLA with viral clearance in an ethnically heterogeneous population

Cited by 11 publications

References 34 publications

Association of HLA class II alleles with hepatitis C virus clearance and persistence in thalassemia patients from Iran

Association of HLA class II alleles with hepatitis C virus clearance and persistence in thalassemia patients from Iran

Hepatitis C Virus Genotype Analyses in Chronic Hepatitis C Patients and Individuals With Spontaneous Virus Clearance Using a Newly Developed Serotyping Assay

Association of cytokine gene polymorphisms with hepatitis C virus infection in a population from Rio de Janeiro, Brazil

Contact Info

Product

Resources

About