Ethnicity Influences Corpus Callosum Dimensions

Abstract

Background and Objective Corpus callosum (CC), the main white matter cable which connects two hemispheres of brain, is important in special procedures such as stereotaxic surgeries vary in size, in different populations. Determination of possible size differences in ethnical groups has special values. Patients and MethodsThe size of the CC on midsagittal view was determined in 76 normal male subjects using MRI of brain hemispheres in northern Iran. The size of rostrum, body, splenium, length, and height of CC was measured for each subject. The width of the body of the corpus callosum (B), the anterior to posterior length (L) and the maximum height (H) of the corpus callosum, and ratios B/L and B/H were also calculated. Results The longitudinal dimensions of the CC were 70.21 mm and 74.05 mm in native Fars and Turkmens, respectively (P < 0.05). The heights were 25 mm and 25.75 mm in native Fars and Turkmen subjects, respectively. The width of CC in Turkmen people was significantly higher than native Fars people (P < 0.05). The Evans index in Turkmen group (0.314) was significantly higher than in native Fars (0.3). The B/L and B/H ratios were nonsignificantly different between two groups. Conclusion The CC parameters vary in different ethnical groups in northern Iran.

Morphometric Analysis of the Corpus Callosum According to Age and Sex in Middle Eastern Arabs: Racial Comparisons and Clinical Correlations to Autism Spectrum Disorder

“…With regard to racial comparisons, this study supports the concept that CC dimensions may vary across different ethnic and racial populations. This is comparable to what was reported by Nouri Hosseini et al (2018), who highlighted that ethnicity may influence CC dimensions. However, it is very difficult to draw a solid conclusion regarding the racial variations in CC from our comparison study due to the presence of several limitations.…”

Demographic reporting across a decade of neuroimaging: a systematic review

“…Race and ethnicity have both been associated with unique phenotypic traits. For example, studies have observed significant differences in the corpus callosum between sub-populations of the Middle East (Allouh et al 2020 ; Hosseini et al 2018 ). In a study comparing brain volumes from healthy White ( n = 44) and Black or African American ( n = 25) individuals, volumetric differences were observed in the left orbitofrontal cortex (Isamah et al 2010 ).…”

“…Health disparities, disease presentation, and patient outcomes are influenced by a wide range of factors including sex, race, and ethnicity (Tang et al 2022 ; Shakeshaft et al 2022 ; Nahar et al 2022 ; Tseng, et al 2020 ). In biomedical and neuroimaging research, differences across demographic groups have been observed in brain structure, anatomy, morphometry, connectivity, development, and disease (Allouh et al 2020 ; Bonkhoff et al 2021 ; Chand et al 2017 ; Delvecchio et al 2021 ; Giedd et al 2012 ; Hosseini et al 2018 ; Liu et al 2020 ). Despite documented differences between demographic groups, historical underrepresentation of minority and female participants has resulted in clinical and biomedical best practices informed by conclusions made using a narrow subset of the population (Brady et al 2021 ; Sardar et al 2014 ; Clayton and Collins 2014 ).…”

MRI-based morphometric analysis of corpus callosum dimensions of adults in Southeast Nigeria

“…The corpus callosum (CC) is the largest inter-hemispheric white matter tract in the human brain and is characterized by variations in morphology among individuals of different gender and race [ 8 , 10 , 14 , 16 , 17 ]. This MRI-based morphometric study of the CC was carried out in southeastern Nigeria.…”