Ethno-medicinal Plants Used by the Traditional Healers of Pachamalai Hills, Tamilnadu, India

Rajadurai, M.; Vidhya, V. G.; Ramya, M Arputha; Bhaskar, Anusha

doi:10.1080/09735070.2009.11886335

Cited by 31 publications

(27 citation statements)

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“…leaves were tested for their antidiabetic efficacy. Wattakaka volubilis (L.f) Stapf (Family: Asclepiadaceae) is widely used in Indian traditional medicines and the leaf paste to treat rheumatic pain, cough, fever and severe cold 6,7 ; leaf paste is taken along with pepper to treat dyspepsia 8 ; bark paste, mixed with hot milk is used internally for treating urinary troubles 9 and leaf powder is taken orally along with cow's milk have antidiabetic activity 10 . In view of above medicinal properties, the present study was designed to investigate the antidiabetic efficacy of ethanolic extract of Wattakaka volubilis leaf in alloxan induced diabetic rats.…”

Section: Introductionmentioning

confidence: 99%

Untitled

2010

IJPSR

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The ethanol extract of Wattakaka volubilis (L. f) Stapf. (Family: Asclepiadaceae) leaf was investigated for its antidiabetic effect in Wistar Albino rats. Diabetes was induced in Albino rats by administration of alloxan monohydrate (150mg/kg, i.p). The ethanol extract of Wattakaka volubilis at a dose of 150mg/kg of body weight was administered at single dose per day to diabetes induced rats for a period of 14 days. The effect of ethanol extract of Wattakaka volubilis leaf extract on blood glucose, plasma insulin, glycosylated haemoglobin, serum lipid profile [total cholesterol, triglycerides, low density lipoprotein -cholesterol (LDL-C), very low density lipoprotein -cholesterol (VLDL-C), and high density lipoprotein-cholesterol (HDL-C) serum protein, albumin, globulin, A/G ratio, serum enzymes [Serum glutamate pyruvate transaminases (SGPT), serum glutamate oxaloacetate transaminases (SGOT) and alkaline phosphatase (ALP)], lipoprotein peroxidation (LPO) antioxidant enzymes (catalase (CAT), superoxide dismutase (SOD), reduced glutathione (GSH) ,glutathione peroxidase (GPx) and glutathione reductase (GR) were measured in the diabetic rats. The ethanol extract of Wattakaka volubilis leaf elicited significant reductions of blood glucose (p<0.01), lipid parameters except HDL-C, serum enzymes and significantly increased HDL-C and antioxidant enzymes. The extracts also caused significant increase in plasma insulin (p<0.01) in the diabetic rats. From the above results it is concluded that ethanol extract of Wattakaka volubilis possesses significant antidiabetic, antihyperlipidaemic and antioxidant effects in alloxan induced diabetic rats.

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Section: Introductionmentioning

confidence: 99%

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2010

IJPSR

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“…11 Ethnopharmacological survey revealed that VN is used for the treatment of respiratory disorders, fever and head ache by the tribals of Madurai district and traditional healers of Pachamali hills (Salem and Tiruchirapalli) of Tamilnadu, India. 22,23 Though all parts of CH and VN are used in ayurvedic medicine, no report is available for acute and sub-chronic study of these plants. Since leaves of these plants are used majorly for treating arthritis in Indian traditional medicine 24-28 the acute and sub-chronic study was carried out in leaf extract.…”

Section: Cardiospermum Halicacabum (Ch) Is a Climbermentioning

confidence: 99%

Acute and sub-chronic toxicity study of methanol leafextract of Cardiospermum halicacabum L and Vitex negundo L in rats

Rajasekaran¹,

Govindarajan²,

Arivukkarasu³

2014

Phcog Commn.

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Introduction: Cardiospermum halicacabum L and Vitex negundo L are distributed throughout the plains of India and used in traditional practice for the treatment of inflammation and rheumatic disorders. The aim of this study is to evaluate acute and sub-chronic toxicity of methanol leaf extracts of Cardiospermum halicacabum (MLECH) and methanol leaf extract of Vitex negundo (MLEVN). MLECH and MLEVN were evaluated for acute and sub-chronic toxicity in mice and rats respectively. Materials and Methods: The acute oral toxicity study was carried out as per the OECD guidelines 423 and the sub-chronic toxicity was carried out as per the guidelines set by OECD 407 with slight modification. Body weight, food consumption, water consumption, hematological parameters, biochemical parameters, organ weight and histopathological analysis were carried out. Results: No sign of toxicity viz. lethargy, jerk, convulsion and mortality was observed upto 2000 mg/kg for MLECH and MLEVN in acute toxicity test. For subchronic toxicity test, single individual (400 mg/kg) and combined doses of MLECH and MLEVN (400 mg/kg each) in equal proportion not exhibited any signs of toxicity and mortality. Conclusion: In acute oral toxicity study, the oral administration of MLECH and MLEVN in mice was found to be safe up to a dose of 2000 mg/kg and in sub-chronic toxicity study no signs of toxicity observed at a dose of 400 mg/kg in rats.

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“…Leaves are used to treat rheumatic pain, cough, fever and severe cold (Muthu et al, 2006). The roots and leaves are used to treat skin diseases, diabetes, cough, jaundice, poison bites and for blood disorders (Rajadurai et al, 2009). Roots are used 414 in the treatment of kidney stones; leaf paste is taken along with pepper to treat dyspepsia (Singh, Govil, Singh, 2007).…”

Section: Introductionmentioning

confidence: 99%

“…Roots are used 414 in the treatment of kidney stones; leaf paste is taken along with pepper to treat dyspepsia (Singh, Govil, Singh, 2007). It is also used to treat rheumatic pain, cough, fever, severe cold, boils and abscesses (Rajadurai et al, 2009;Silija, Varma, Mohanan, 2008). Paste of its bark is mixed with hot milk and used internally for treating urinary trouble.…”

Section: Introductionmentioning

confidence: 99%

Antihyperglycemic and neuroprotective effects of Wattakaka volubilis (L.f.) Stapf root against streptozotocin induced diabetes

Haroon

Murali

2016

Braz. J. Pharm. Sci.

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Murva is an important drug in Ayurveda. Wattakaka volubilis is used as one of the botanical sources of Murva. The aim of this study is to evaluate the effect of the alcohol extract of W. volubilis root in streptoztocin (STZ) induced diabetes and diabetic neuropathy. Diabetes mellitus (DM) was induced by the administration of STZ (45 mg/kg, i.p). DM was induced within 72 h. Diabetic animals were treated with glimepiride (0.5 mg/kg) and ethyl alcohol extract 100 and 200 mg/kg for 21 d. After determining the changes in fasting serum glucose and lipid profile, animals were further treated for a period of 15 d to determine the protective effect of extract against diabetic neuropathy. All the alcohol extract treated animals, showed a significant decrease in serum glucose level (P<0.001), and overall decrease in the severity of diabetic neuropathy. Alcohol extract of W. volubilis root showed antihyperglycemic activity and beneficial protection against diabetic neuropathy and hence can be a promising agent for treatment and prevention of diabetic neuropathy.

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Ethno-medicinal Plants Used by the Traditional Healers of Pachamalai Hills, Tamilnadu, India

Cited by 31 publications

References 1 publication

Untitled

Untitled

Acute and sub-chronic toxicity study of methanol leafextract of Cardiospermum halicacabum L and Vitex negundo L in rats

Antihyperglycemic and neuroprotective effects of Wattakaka volubilis (L.f.) Stapf root against streptozotocin induced diabetes

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