Ethnobotanical, phytochemical and toxicological studies of Ghagra shak (Xanthium strumarium L.) growing in Bangladesh

Islam, Mohammad Rashedul; Uddin, Mohammad Zashim; Rahman, Mohammad Sharifur; Tutul, Ershad; Rahman, Mohammed Z.; Hassan, Md. Abul; Faiz, Mohammad Abul; Hossain, M Sarwar; Hussain, Mazhar; Rashid, Mohammad A.

doi:10.3329/bmrcb.v35i3.3658

Cited by 17 publications

(9 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In addition, several North American Indian tribes and Zuni tribes apply this plant to relieve constipation, diarrhoea and vomiting [1]. Besides, X. strumarium is also reported as a folk herbal medicine in Bangladesh for the treatment of urinary disorder, ear infection, diabetic, and gastric disorder [8].…”

Section: Traditional Usagesmentioning

confidence: 99%

Traditional Uses, Botany, Phytochemistry, Pharmacology, Pharmacokinetics and Toxicology of Xanthium strumarium L.: A Review

et al. 2019

View full text Add to dashboard Cite

Xanthium strumarium L. (Asteraceae) is a common and well-known traditional Chinese herbal medicine usually named Cang-Er-Zi, and has been used for thousands of years in China. The purpose of this paper is to summarize the progress of modern research, and provide a systematic review on the traditional usages, botany, phytochemistry, pharmacology, pharmacokinetics, and toxicology of the X. strumarium. Moreover, an in-depth discussion of some valuable issues and possible development for future research on this plant is also given. X. strumarium, as a traditional herbal medicine, has been extensively applied to treat many diseases, such as rhinitis, nasal sinusitis, headache, gastric ulcer, urticaria, rheumatism bacterial, fungal infections and arthritis. Up to now, more than 170 chemical constituents have been isolated and identified from X. strumarium, including sesquiterpenoids, phenylpropenoids, lignanoids, coumarins, steroids, glycosides, flavonoids, thiazides, anthraquinones, naphthoquinones and other compounds. Modern research shows that the extracts and compounds from X. strumarium possess wide-ranging pharmacological effects, including anti- allergic rhinitis (AR) effects, anti-tumor effects, anti-inflammatory and analgesic effects, insecticide and antiparasitic effects, antioxidant effects, antibacterial and antifungal effects, antidiabetic effects, antilipidemic effects and antiviral effects. However, further research should focus on investigating bioactive compounds and demonstrate the mechanism of its detoxification, and more reasonable quality control standards for X. strumarium should also be established.

show abstract

Section: Traditional Usagesmentioning

confidence: 99%

Traditional Uses, Botany, Phytochemistry, Pharmacology, Pharmacokinetics and Toxicology of Xanthium strumarium L.: A Review

et al. 2019

View full text Add to dashboard Cite

show abstract

“…8,9 Previous chemical studies of Brassica genus reported the isolation of phenolics and organic acids. [10][11][12][13] As a part of our continuing studies on medicinal plants of Bangladesh, [14][15][16][17][18] our aim was to screen B. rapa subspecies chinensis for primary analgesic and antidepressant activities. This is the first time report regarding these bioassays of this plant and it might be useful for inspiring bioactivity guided isolation of compounds from this herb.…”

Section: Brassica Rapa Subsp Chinensis (Bengali Namementioning

confidence: 99%

Analgesic and antidepressant activities of Brassica rapa subspecies chinensis (L.) Hanelt on Swiss-albino mice model

Rahman

Jahan

Rahman

et al. 2016

Bangladesh Med Res Counc Bull

Self Cite

View full text Add to dashboard Cite

Bangladesh being a subtropical country provides varieties of herbs and vegetables. Brassica is a broad genus available in Bangladesh and it encompasses a lot of nutritive herbs. Among these, Brassica rapa subspecies chinensis (L.) Hanelt (Family-Brassicaceae) is popular in many parts of the world. In the quest of medicinal property, this plant was investigated here for observing analgesic and antidepressant activities in Swiss-albino mice model. The herb was extracted well with methanol and then assayed by acetic acid-induced writhing and tail immersion methods for analgesic action. Besides, thiopental sodium induced sleeping time test, tail suspension test and forced swim test were conducted for the evaluation of its antidepressant activity. The plant extract was orally administered to the mice at 200 and 400 mg/kg body weight and it exhibited significant analgesic and antidepressant activities in compare to the controlled groups. This is the first time comprehensive report for analgesic and antidepressant activities of this plant.

show abstract

“…En el caso de Xanthium strumarium, que posee una proporción similar de glucósidos diterpénicos, algunos artículos proponen que el agente tóxico está presente solamente en las semillas y brotes durante el estadio de cotiledones, y su ausencia en las plantas con cuatro o más hojas (18) . Sin embargo, otros estudios aseguran que el extracto de la planta madura también posee una toxicidad importante, produciendo las mismas alteraciones observadas en la toxicidad por ATR y CATR (19) . Estos últimos coinciden con los resultados obtenidos con el extracto de hojas de la planta madura de Xanthium spinosum.…”

Section: Extrapolación De Datosunclassified

Toxicidad aguda de las hojas de Xanthium spinosum en ratones BALB/C

Silvero-Isidre

Morínigo-Guayuán

Meza-Ojeda

et al. 2016

Rev Peru Med Exp Salud Publica

View full text Add to dashboard Cite

RESUMENLas hojas de la planta Xanthium spinosum se utilizan culturalmente en Paraguay por sus propiedades medicinales. Se evaluó la toxicidad aguda del extracto de hojas maduras; para el estudio se seleccionaron 35 ratones BALB/C machos que fueron distribuidos en 7 grupos, 6 de ensayo y 1 de control. El extracto fue preparado en concentraciones de 6 y 9% (g/dL); se administró la solución 6% a tres grupos y la solución 9% a los otros tres grupos, con dosis entre 200 y 1000 mg/kg. Al final de 14 días de observación, se extrajeron muestras de sangre para estudios laboratoriales de urea y transaminasas, además de órganos para estudios anatomopatológicos. Se determinaron aumentos en los niveles de GOT y urea en comparación al grupo control. Se concluye que el consumo del extracto de hojas maduras de Xanthium spinosum puede causar daño hepático.Palabras clave: Xanthium spinosum; Toxicidad aguda; Plantas medicinales (fuente: DeCS BIREME). ABSTRACTThe leaves of the Xanthium spinosum plant have been used culturally in Paraguay for their medicinal properties. Acute toxicity of mature leaf extract was evaluated. For the study, 35 Balb/c mice were selected and allocated into 7 groups, 6 test groups and 1 control group. The extract was prepared in concentrations of 6% and 9% (g/dL). The 6% concentration was administrated to 3 test groups and 9% concentration to the remaining 3 groups, with doses between 200 and 1000 mg/kg per mouse. After 14 days of observation, blood samples were taken for laboratory studies of urea and transaminases and organs were examined for pathological studies. There were increased levels of GOT and urea in the test groups compared to the control group. In conclusion, the consumption of mature leaf extract of Xanthium spinosum can cause hepatic damage.

show abstract

Ethnobotanical, phytochemical and toxicological studies of Ghagra shak (Xanthium strumarium L.) growing in Bangladesh

Cited by 17 publications

References 20 publications

Traditional Uses, Botany, Phytochemistry, Pharmacology, Pharmacokinetics and Toxicology of Xanthium strumarium L.: A Review

Traditional Uses, Botany, Phytochemistry, Pharmacology, Pharmacokinetics and Toxicology of Xanthium strumarium L.: A Review

Analgesic and antidepressant activities of Brassica rapa subspecies chinensis (L.) Hanelt on Swiss-albino mice model

Toxicidad aguda de las hojas de Xanthium spinosum en ratones BALB/C

Contact Info

Product

Resources

About