Ethnobotanical Survey of Antimalarial Medicinal Plants Used in Butebo County, Eastern Uganda

Philip, Koshy; Elizabeth, Mwangi Muthoni; Cheplogoi, Peter K.; Samuel, Kennedy B.

doi:10.9734/ejmp/2017/35368

Cited by 21 publications

(22 citation statements)

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“…Z. chalybeum has been moderately studied www.nature.com/scientificreports/ in the past. The majority of publications documented its traditional use in Uganda 24,[39][40][41][42] , Kenya 43 , Tanzania 44 and Ethiopia 45 . Fagaramide, an antiplasmodial natural product, was previously isolated from Z. chalybeum stem bark 46 .…”

Section: Discussionmentioning

confidence: 99%

Targeting ESKAPE pathogens with anti-infective medicinal plants from the Greater Mpigi region in Uganda

Schultz

Anywar

Tang

et al. 2020

Sci Rep

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Antibiotic resistance poses one of the greatest threats to global health today; conventional drug therapies are becoming increasingly inefficacious and limited. We identified 16 medicinal plant species used by traditional healers for the treatment of infectious and inflammatory diseases in the Greater Mpigi region of Uganda. Extracts were evaluated for their ability to inhibit growth of clinical isolates of multidrug-resistant ESKAPE pathogens. Extracts were also screened for quorum quenching activity against S. aureus, including direct protein output assessment (δ-toxin), and cytotoxicity against human keratinocytes (HaCaT). Putative matches of compounds were elucidated via LC-FTMS for the best-performing extracts. These were extracts of Zanthoxylum chalybeum (Staphylococcus aureus: MIC: 16 μg/mL; Enterococcus faecium: MIC: 32 μg/mL) and Harungana madagascariensis (S. aureus: MIC: 32 μg/mL; E. faecium: MIC: 32 μg/mL) stem bark. Extracts of Solanum aculeastrum root bark and Sesamum calycinum subsp. angustifolium leaves exhibited strong quorum sensing inhibition activity against all S. aureus accessory gene regulator (agr) alleles in absence of growth inhibition (IC 50 values: 1-64 μg/mL). The study provided scientific evidence for the potential therapeutic efficacy of these medicinal plants in the Greater Mpigi region used for infections and wounds, with 13 out of 16 species tested being validated with in vitro studies. The rise of antimicrobial resistance (AMR) requires mobilization of political, financial and research investment due to its emergence as a global health hazard that threatens the ability to treat infectious diseases 1. According to the World Health Organization, AMR poses "one of the biggest threats to global health, food security, and development today" and can affect anyone in any country and of any age 2. Today, AMR already accounts for 700,000 deaths annually. By 2050, this figure is estimated to reach more than 10 million deaths per year, which is more people than currently die from cancer 3. Because effective antibiotics are critical for treatment of bacterial infections and for procedures where there is a high risk of infection, e.g. surgery, new anti-infectives are needed to overcome this global threat 4. The issue of resistance is not uniformly spread across all bacteria 5. Six species have been identified by the Infectious Disease Society of America (IDSA) as being especially dangerous due to their potential multidrug resistance mechanisms and virulence. They are referred to as 'ESKAPE' pathogens, which is an acronym for Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa and Enterobacter species. This group of pathogenic bacteria encompasses both Gram-negative and Gram-positive species that are capable of 'escaping' bactericidal action of conventional

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Section: Discussionmentioning

confidence: 99%

Targeting ESKAPE pathogens with anti-infective medicinal plants from the Greater Mpigi region in Uganda

Schultz

Anywar

Tang

et al. 2020

Sci Rep

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“…The mode of preparation and use of herbs among different communities vary depending on the nature of the herb and plant parts used for malaria treatment [10]. Most commonly, the herbal medicines are prepared as water extracts in the form of decoction and infusion or as steam baths (Table 1) [19, 23]. The herbal plant water extract is made mostly by boiling a handful of the medicinal plant parts such as leaves in a litre of water and then given to the patient to take orally (Table 1) [23].…”

Section: Mode Of Preparation and Use Of Herbs In Treatment Of Malamentioning

confidence: 99%

Exploring Antimalarial Herbal Plants across Communities in Uganda Based on Electronic Data

Okello

Kang

2019

Evidence-Based Complementary and Alternative Medicine

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Malaria is one of the most rampant diseases today not only in Uganda but also throughout Africa. Hence, it needs very close attention as it can be severe, causing many deaths, especially due to the rising prevalence of pathogenic resistance to current antimalarial drugs. The majority of the Ugandan population relies on traditional herbal medicines for various health issues. Thus, herein, we review various plant resources used to treat malaria across communities in Uganda so as to provide comprehensive and valuable ethnobotanical data about these plants. Approximately 182 plant species from 63 different plant families are used for malaria treatment across several communities in Uganda, of which 112 plant species have been investigated for antimalarial activities and 96% of the plant species showing positive results. Some plants showed very strong antimalarial activities and could be investigated further for the identification and validation of potentially therapeutic antimalarial compounds. There is no record of an investigation of antimalarial activity for approximately 39% of the plant species used for malaria treatment, yet these plants could be potential sources for potent antimalarial remedies. Thus, the review provides guidance for areas of further research on potential plant resources that could be sources of compounds with therapeutic properties for the treatment of malaria. Some of the plants were investigated for antimalarial activities, and their efficacy, toxicity, and safety aspects still need to be studied.

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“…Out of the 27 species reported by Tabuti (2008), 5 species (A. indica, C. cajan, M. indica, M. oleifera and V. amygdalina) were commonly used in other regions of Uganda. Philip et al (2017) also studied ethnobotanical survey on medicinal plants used for malaria in Butebo County in the eastern region of Uganda which comprised five sub-Counties: Kakoro, Kabwangasi, Petete, Butebo and Kibale in Pallisa District. In his study, 50 respondents were interviewed, comprising 10 from each sub-County from which 33 plant species belonging to 23 families were reported.…”

Section: Resultsmentioning

confidence: 99%

“…Katuura et al (2007) studied medicinal plants used for malaria in Mbarara municipality and Rwampara County from where 20 medicinal plants were reported, out of which 19 species were identified with their leaves or roots being used as decoctions or infusions (Table 1), either individually or in combination. Four of the plant species namely, M. indica, T. assiatica, V. amygdalina and V. lasiopus, commonly used for malaria treatment in this Hussein and El-Sebakhy, 1974;Rastrelli et al, 1997;Broussalis et al, 1999;Gadhi et al, 2001;Murillo et al, 2001;Wu et al, 2002;Hamill et al, 2000;Shi et al, 2004;Belay, 2011;Stangeland et al, 2011;Jimenez-Arellanes et al, 2012;Zamilpa et al, Tidjani et al, 1989;Stone, 1992;Hamill et al, 2000;Tabuti 2008;Ghimeray et al, 2009;Mbaya et al, 2010;Stangeland et al, 2011;Ashafa et al, 2012;Wang et al, 2013;Adia et al, 2014;Jamra et al, 2014;Mahilrajan et al, 2014;Prashanth and Krishnaiah, 2014;Yan et al, 2015;Kamatenesi et al, 2011;Anywar et al, 2016;Anand et al, 2016;Opio et al, 2017;Philip et al, 2017;Sinha et al, 2017 Bidens pilosa L. Geissberger and Séquin, 1991;…”

Section: Resultsmentioning

confidence: 99%

“…stapf (Poaceae) Vinitketkumnuen et al, 1994;Viana et al, 2000;Sacchetti et al, 2005;Adeneye and Agbaje. 2007;Fandohan et al, 2008;Silva et al, 2008;Blanco et al, 2009;Pereira et al, 2009;Figueirinha et al, 2010;Olivero-Verbel et al, 2010;Bassolé et al, 2011;Stangeland et al, 2011;Machado et al, 2012;Francisco et al, 2013;Gbenou et al, 2013;Ukpai and Amaechi, 2012;Bao et al, Adia et al, 2014;Ekpeyong et al, 2015;Sagradas et al, 2015;Chukwuocha et al, 2016;De Silva et al, 2017;Philip et al, 2017;Venzon et al, 2018 Hoslundia Weenen et al, 1990;Achenbach et al, 1992;Gundidza et al, 1992;Mujovo et al, 2008;Usman et al, 2010;Gathirwa et al, 2011;Lacroix et al, 2011;Stangeland et al, 2011;Salame et al, 2012;Asiimwe et al, 2013;Adia et al, 2014;Babarinde et al, 2014;Kamatenesi et al, 2011;Anywar et al, 2016;Opio et al, 2017…”

Section: Resultsunclassified

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A review for selecting medicinal plants commonly used for malaria in Uganda

Ajayi¹,

Elujoba²,

Kasali³

et al. 2020

Afr. J. Pharm. Pharmacol.

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Ethnobotanical Survey of Antimalarial Medicinal Plants Used in Butebo County, Eastern Uganda

Cited by 21 publications

References 0 publications

Targeting ESKAPE pathogens with anti-infective medicinal plants from the Greater Mpigi region in Uganda

Targeting ESKAPE pathogens with anti-infective medicinal plants from the Greater Mpigi region in Uganda

Exploring Antimalarial Herbal Plants across Communities in Uganda Based on Electronic Data

A review for selecting medicinal plants commonly used for malaria in Uganda

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