Ethnobotany of medicinal plants with antimalarial potential in Northern Nigeria

Mahmoud, Abdulrahman Dogara; Labaran, Isah; Yunusa, Abdulkadir

doi:10.32859/era.19.32.1-8

Cited by 7 publications

(8 citation statements)

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“…For the majority of human history, people have relied on local flora to heal a broad range of maladies, both those of themselves and their domesticated animals [ 6 ]. Depending on the community's culture and religious beliefs, some of the plants were also used for religious rituals [ 3 ]. Traditional medicine as a collection of practices and knowledge gathered from the observations and practical experiences of previous generations was described and used for the diagnosis, eradication, and prevention of physical and nonphysical sickness [ 7 ].…”

Section: Resultsmentioning

confidence: 99%

“…Many medications are available to combat inflammation, but long-term usage may result in side effects such as nausea, vomiting, bone marrow depression, and fluid or salt retention [ 6 ]. A new supply of structurally essential compounds from plants has been discovered by traditional medicine, which means that it is always expanding its horizons [ 3 ]. It is well known that plants are rich in chemical compounds.…”

Section: Resultsmentioning

confidence: 99%

“…Malaria has long been seen as a public health threat around the globe. More than 3.2 billion individuals are in danger of contacting malaria parasites, according to estimates [ 3 ]. The histology investigations of the liver and spleen indicated serious abnormalities.…”

Section: Resultsmentioning

confidence: 99%

“…People have resorted to natural sources for cures for various ailments since ancient times [ 1 , 2 ]. For millennia, people throughout the world have relied on medicinal herbs or plants [ 3 ]. Even more impressively, almost 25% of modern drugs are derived from the stem of plants in some way.…”

Section: Introductionmentioning

confidence: 99%

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Ethnopharmacology, Biological Evaluation, and Chemical Composition of Ziziphus spina-christi (L.) Desf.: A Review

Abdulrahman

Zakariya

Hama

et al. 2022

Advances in Pharmacological and Pharmaceutical Sciences

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Medicinal plants are the primary raw materials used in the production of medicinal products all over the world. As a result, more study on plants with therapeutic potential is required. The tropical tree Ziziphus spina belongs to the Rhamnaceae family. Biological reports and traditional applications including management of diabetes and treatment of malaria, digestive issues, typhoid, liver complaints, weakness, skin infections, urinary disorders, obesity, diarrhoea, and sleeplessness have all been treated with different parts of Z. spina all over the globe. The plant is identified as a rich source of diverse chemical compounds. This study is a comprehensive yet detailed review of Z. spina based on major findings from around the world regarding ethnopharmacology, biological evaluation, and chemical composition. Scopus, Web of Science, BioMed Central, ScienceDirect, PubMed, Springer Link, and Google Scholar were searched to find published articles. From the 186 research articles reviewed, we revealed the leaf extract to be significant against free radicals, microbes, parasites, inflammation-related cases, obesity, and cancer. Chemically, polyphenols/flavonoids were the most reported compounds with a composition of 66 compounds out of the total 193 compounds reported from different parts of the plant. However, the safety and efficacy of Z. spina have not been wholly assessed in humans, and further well-designed clinical trials are needed to corroborate preclinical findings. The mechanism of action of the leaf extract should be examined. The standard dose and safety of the leaf should be established.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Ethnopharmacology, Biological Evaluation, and Chemical Composition of Ziziphus spina-christi (L.) Desf.: A Review

Abdulrahman

Zakariya

Hama

et al. 2022

Advances in Pharmacological and Pharmaceutical Sciences

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“…Medicinal plants used in folk medicine provides a significant contributions to health improvement all over the world. Plants are still playing a vital role in the health improvement of developed and developing countries (2). Most of modern medicines were derived from medicinal plants.…”

Section: Introductionmentioning

confidence: 99%

Antioxidant, alpha glucosidase and antibacterial evaluation of Syzygium mytifolium (Roxb.) Walp.

Abdulrahman

2021

Plant Sci. Today

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Medicinal plants have been the major source of combating and treating infectious diseases and health disorders throughout the ages. To explore new sources of inexpensive and safe antioxidants and antibiotics. The antioxidant and antibacterial potential of different extracts Syzygium mytifolium (Roxb.) Walp. were evaluated through 1,1-Diphenyl-2-Picryl Hydrazyl (DPPH), ferric reducing antioxidant power (FRAP), ?-glucosidase inhibition, disk diffusion and agar well methods. The leaves, bark, root and whole plant of Syzygium mytifolium were extracted with various solvents viz ethanol, methanol and aqueous to give crude extracts, respectively. Among all, the ethanolic extract showed high antioxidant activity in terms of radical scavenging activity, reducing power and alpha-glucosidase inhibition at 1.84 µg/ml, 40.2 mmol/gm and 14.34 µg/ml, respectively. All the tested parts of the plant exhibited moderate to higher range of antibacterial activity against bacterial pathogens with the inhibition zones ranged between 2-27.8 mm. Syzygium mytifolium will serve as a very good source for the development of antioxidant supplements and antibiotics for addressing infectious pathogens and improvement of health status.

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Molecular Mechanics with Generalized Born Surface Area (MMGBSA) Calculations and Docking Studies Unravel some Antimalarial Compounds Using Heme O Synthase as Therapeutic Target

Adelusi,

Bolaji,

Ojo

et al. 2023

ChemistrySelect

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The enzyme Heme O Synthase (HOS) is essential for producing heme A and heme O, which are critical for defense against reactive oxygen species, drug detoxification, gas synthesis, transport, and electron transport in Plasmodium species. It has become vital to discover inhibitory molecules/compounds/medicines that target the synthesis of heme due to the emergence of drug‐resistant strains of Plasmodium falciparum. Therefore, in this study, we employed molecular mechanics with Generalized Born surface area (MMGBSA) calculations and docking studies to investigate potential antimalarial compounds targeting HOS from antimalarial botanicals. Screening these compounds, we have identified 2 compounds; Meliantrol and Tamarixetin with better binding affinities (−8.4 Kcal/mol and −8.3 Kcal/mol respectively) than the current standard inhibitor(Inabenfide) of HOS (−8.0 Kcal/mol). The MMGBSA calculations provided insight into the thermodynamics of the binding process and helped identify key interactions responsible for the stability of the HOS‐ligand complex. In addition, the 2 compounds were further screened comparatively with the standard HOS inhibitor considering their protein‐ligand interaction profile and ADMET profile and these 2 selected compounds outperformed Inabenfide. Our results predict that these compounds are potential drug candidates with domiciled therapeutic functions against Malaria therefore, open doors for more experimental validations for drug development.

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Ethnobotany of medicinal plants with antimalarial potential in Northern Nigeria

Cited by 7 publications

References 0 publications

Ethnopharmacology, Biological Evaluation, and Chemical Composition of Ziziphus spina-christi (L.) Desf.: A Review

Ethnopharmacology, Biological Evaluation, and Chemical Composition of Ziziphus spina-christi (L.) Desf.: A Review

Antioxidant, alpha glucosidase and antibacterial evaluation of Syzygium mytifolium (Roxb.) Walp.

Molecular Mechanics with Generalized Born Surface Area (MMGBSA) Calculations and Docking Studies Unravel some Antimalarial Compounds Using Heme O Synthase as Therapeutic Target

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