Ethnomedicinal uses, biological activities, phytochemistry and conservation of African ginger (Siphonochilus aethiopicus): A commercially important and endangered medicinal plant

Adebayo, S.A.; Amoo, Stephen O.; Mokgehle, Salmina N.; Aremu, Abdulfatai

doi:10.1016/j.jep.2020.113459

Cited by 16 publications

(11 citation statements)

References 44 publications

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“…On the other hand, 20% of the participants purchase African ginger from the muthi shops and 10% sourced the planting material from the neighbours (Figure 5). To enhance the conservation strategies for African ginger, to ensure the long-term viability of African ginger, in-situ and ex-situ conservation techniques could be implemented [24]. In-situ cultivation of African ginger in home gardens help to protect native species and preserve natural communities.…”

Section: Indigenous Conservation Methods For African Gingermentioning

confidence: 99%

“…vation strategies for African ginger, to ensure the long-term viability of African ginger, insitu and ex-situ conservation techniques could be implemented [24]. In-situ cultivation of African ginger in home gardens help to protect native species and preserve natural communities.…”

Section: Indigenous Conservation Methods For African Gingermentioning

confidence: 99%

“…Although nine (9) health conditions were indicated, treatment of asthma, chest pains, cough, menstruation disorder, stomach-ache and sexually transmitted infections were the dominant (mentioned by 7-10 participants) ones. In Africa, several ethnic groups are known to utilise African ginger for treating cough, colds, asthma, pain-related conditions, headache and respiratory problems [24]. In this study, the type and frequency of the diseases/health conditions recorded may be linked to the gender distribution of the participants.…”

Section: Medicinal Uses Of African Gingermentioning

confidence: 96%

“…Women are known as important players for the documentation of indigenous system of medicine and health-care needs [37]. As reported in the study area, African ginger is used for managing menstruation pains among women in southern Africa [24,46]. African ginger is chewed by woman to relieve menstruation pains.…”

Section: Medicinal Uses Of African Gingermentioning

confidence: 99%

“…In South Africa, Siphonochilus aethiopicus (family: Zingiberaceae), commonly known as African ginger is a popular medicinal plant that is currently over-harvested for trade in the informal muthi markets [19,23,24]. In addition, the plant species is in high demand from local companies to formulate medicines in form of tablets, capsules and syrups [24]. Researchers are continuously exploring different conventional means to ensure the increasing demand of African ginger is met national and international [25][26][27][28].…”

Section: Introductionmentioning

confidence: 99%

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Indigenous Knowledge on the Uses, Sustainability and Conservation of African Ginger (Siphonochilus aethiopicus) among Two Communities in Mpumalanga Province, South Africa

et al. 2022

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Harvesting of medicinal plants in the wild has an impact on sustainability of medicinal plants, which leads to the need for intervention in terms of conservation strategies. Siphonochilus aethiopicus, commonly known as African ginger or wild ginger is used to cure a variety of health conditions/illnesses, such as coughs, colds, asthma, nausea, headaches and pains. This study explored the potential role of indigenous knowledge on the uses, sustainability, and conservation strategies for African ginger among two communities in Mpumalanga province. Qualitative method entailing in-depth interviews were used for this research. We used a non-probability sample (snow-balling) to recruit ten (10) participants that comprised of four traditional health practitioners, four knowledge holders and two herbalists, considered as experts on African ginger in the study area. The data was analysed using thematic analysis. The diverse indigenous knowledge on the uses of African ginger were divided into two categories (diseases and spiritual/cultural purposes) among the local communities. African ginger is indigenous to South Africa and the plant species in the wild is mainly lost to commercial trade. As revealed by the participants, the multiple uses of African ginger are major contributing factors exacerbating the demands for the plant. The uses of African ginger have resulted in the scarcity and possibly extinction of this plant species in the wild, which remain a major concerns to several stakeholders especially traditional health practitioners. Harvesting of the rhizomes of African ginger is recommended instead of the root given the relative ease and higher chances for survival and regeneration. To ensure the sustainable utilisation of African ginger, its cultivation was recommended by the participants. However, there is a need for further intervention to assess how the community members can be assisted with developing and adopting indigenous conservation protocols for the continuous sustainability of African ginger. In addition, it is pertinent to strongly discourage the indiscriminate destruction of natural habitats and create more awareness on the importance of designating protected areas among local communities.

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Section: Indigenous Conservation Methods For African Gingermentioning

confidence: 99%

Section: Indigenous Conservation Methods For African Gingermentioning

confidence: 99%

Section: Medicinal Uses Of African Gingermentioning

confidence: 96%

Section: Medicinal Uses Of African Gingermentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Indigenous Knowledge on the Uses, Sustainability and Conservation of African Ginger (Siphonochilus aethiopicus) among Two Communities in Mpumalanga Province, South Africa

et al. 2022

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Evaluation of cytotoxic effect of siphonochilone from African ginger: an in vitro analysis

Ortigosa‐Palomo,

Fuentes‐Ríos,

Quiñonero

et al. 2024

Environmental Toxicology

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Plants provide a wide array of compounds that can be explored for potential anticancer properties. Siphonochilone, a furanoterpene that represents one of the main components of the African plant Siphonochilus aethiopicus, shows numerous health benefits. However, to date, its antiproliferative properties have not been tested. The aim of this study was to analyze the cytotoxic effects of siphonochilone on a panel of cancer cell lines and its underlying mechanism of action. Our results demonstrated that siphonochilone exhibited significant cytotoxic effects on pancreatic, breast, lung, colon, and liver cancer cell lines showing a IC50 ranging from 22 to 124 μM at 72 h of treatment and highlighting its cytotoxic effect against MCF7 and PANC1 breast and pancreas cancer cell lines (22.03 and 39.03 μM, respectively). Cell death in these tumor lines was mediated by apoptosis by the mitochondrial pathway, as evidenced by siphonochilone‐induced depolarization of the mitochondrial membrane potential. In addition, siphonochilone treatment involves the generation of reactive oxygen species that may contribute to apoptosis induction. In this work, we described for the first time the cytotoxic properties of siphonochilone and provided data about the molecular processes of cell death. Although future studies will be necessary, our results support the interest in this molecule in relation to their clinical application in cancer, and especially in breast and pancreatic cancer.

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Siphonochilus aethiopicus

Viljoen¹,

Kamatou²,

Fouché³

2023

The South African Herbal Pharmacopoeia

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Ethnomedicinal uses, biological activities, phytochemistry and conservation of African ginger (Siphonochilus aethiopicus): A commercially important and endangered medicinal plant

Cited by 16 publications

References 44 publications

Indigenous Knowledge on the Uses, Sustainability and Conservation of African Ginger (Siphonochilus aethiopicus) among Two Communities in Mpumalanga Province, South Africa

Indigenous Knowledge on the Uses, Sustainability and Conservation of African Ginger (Siphonochilus aethiopicus) among Two Communities in Mpumalanga Province, South Africa

Evaluation of cytotoxic effect of siphonochilone from African ginger: an in vitro analysis

Siphonochilus aethiopicus

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