Ethnopharmacological uses and public knowledge regarding Cinnamomum zeylanicum in Khobar, Saudi Arabia

Almubayedh, Hanine; Ahmad, Rizwan; Naqvi, Atta Abbas

doi:10.4103/jpbs.jpbs_71_18

Cited by 4 publications

(1 citation statement)

References 24 publications

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“…Though animal studies had provided evidence of the positive effects of cinnamon and there is gaining popularity in the traditional use against diabetes [12], very few human clinical trials on this particular species only in the Iranian population make up the paucity of sufficient scientific evidence as well as there has been no work proving it at the biochemical level in humans [13,14]. Studies on other species of cinnamon (C. cassia or C. burmannii) had also some clashes, e.g., lack of species name, origin, quality, purity, grade, etc.…”

Section: Introductionmentioning

confidence: 99%

Efficacy of Young Cinnamomum zeylanicum Blume Bark on Hyperglycemia and PTPase Activity in Type 2 Diabetes

Mandal¹,

Sharma²,

Yadav³

et al. 2023

Cureus

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Diabetes is a major public health concern and natural easy-going remedies are being searched. Since Cinnamomum zeylanicum Blume has a low coumarin concentration and possible insulin-enhancing properties, it is preferred over all other cinnamon species. Although similar research has been done on humans, there have been very few studies on this particular species, and none among South Asians. Moreover, no human trial that properly described their intervening agent (C. zeylanicum) and checked its efficacy at the molecular level along with clinical variables was conducted. Therefore, the current research aimed to explore the effects of C. zeylanicum on the glycemic index, lipid profile, and expression of the protein tyrosine phosphatase 1 B (PTP1B) enzyme in the peripheral blood mononuclear cells (PBMC) in type 2 diabetes.We examined the presence of bioactive compounds in young C. zeylanicum bark (Alba grade) from native Sri Lanka using gas chromatography-mass spectrometry, high-performance thin-layer chromatography, and thin-layer chromatography before introducing it in the clinical study where trans-Cinnamaldehyde was found to be a major chemical constituent (>60%). Then, from January 2020 to March 2022, a randomized double-blinded placebo-controlled trial was carried out in the Diabetic Clinic at AIIMS Rishikesh. A total of 154 diabetic patients were enrolled and were taken either cinnamon or placebo capsules (1.5 g/day) for 120 days on an empty stomach with warm water along with their conventional treatment. Reduction in fasting blood glucose levels in the cinnamon group was found -35.50% (95% CI, -173 to 58.4), whereas in the placebo group change was 5.00% (95% CI, -165 to 224). For glycosylated hemoglobin, it differed -0.85% (95% CI, -8.2 to 1.6) in the cinnamon group compared to the placebo where it was found 0.15% (95% CI, -6.1 to 5.5). PTP1B expression in PBMC was determined from pre-and post-trial blood samples using the Western Blot, and significant inhibition was also observed (p=0.039). The study result depicts, C. zeylanicum is emerging as a beneficial plant for type 2 diabetes in Northern India and could be used as an adjunctive treatment rather than as a standalone managerial remedy.

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Section: Introductionmentioning

confidence: 99%