Ethnopharmacology and Therapeutic Value of Bridelia micrantha (Hochst.) Baill. in Tropical Africa: A Comprehensive Review

Maroyi, Alfred

doi:10.3390/molecules22091493

Cited by 24 publications

(22 citation statements)

References 64 publications

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“…The methanol and aqueous extracts of A. coriaria have very low cytotoxicity (CC 50 > 500 μg/ml) against human embryonic lung fibroblast cells (HELF) (Kigoundu et al, 2009). The methanol, ethanol, ethyl acetate and diethyl ether extracts of A. coriaria were not toxic to human keratinocyte cell line (HaCaT) IC 50 > 512 (Maroyi, 2017). Albizia spp.…”

Section: Albizia Coriaria Olivmentioning

confidence: 99%

“…Baill. Maroyi (2017) conducted an extensive review on B. micrantha and showed that it is traditionally used across many parts of Africa for treating various ailments including gastric ulcers, sexually transmitted infections and coughs. B. micrantha is widely used in treating a variety of opportunistic infections among PLHIV in Uganda (Anywar et al, 2020a).…”

Section: Albizia Coriaria Olivmentioning

confidence: 99%

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A Review of the Toxicity and Phytochemistry of Medicinal Plant Species Used by Herbalists in Treating People Living With HIV/AIDS in Uganda

et al. 2021

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Introduction: Despite concerns about toxicity, potentially harmful effects and herb-drug interactions, the use of herbal medicines remains widely practiced by people living with HIV/AIDS (PLHIV) in Uganda.Objective: The objective of the paper was to comprehensively review the literature on the toxicity and chemical composition of commonly used medicinal plant species in treating PLHIV in Uganda.Methods: We reviewed relevant articles and books published over the last sixty years on ethnobotany, antiviral/anti-HIV activity, toxicity, phytochemistry of Vachellia hockii, Albizia coriaria, Bridelia micrantha, Cryptolepis sanguinolenta, Erythrina abyssinica, Gardenia ternifolia, Gymnosporia senegalensis, Psorospermum febrifugium, Securidaca longipendunculata, Warburgia ugandensis and Zanthoxylum chalybeum and their synonyms. We searched PubMed, Web of Science, Scopus, Science Direct and Google Scholar.Discussion: Most of the plant species reviewed apart from P. febrifugium, S. longipedunculata and C. sanguinolenta lacked detailed phytochemical analyses as well as the quantification and characterization of their constituents. Crude plant extracts were the most commonly used. However, purified/single component extracts from different plant parts were also used in some studies. The U87 human glioblastoma was the most commonly used cell line. Water, ethanol, methanol and DMSO were the commonest solvents used. In some instances, isolated purified compounds/extracts such as Cryptolepine and Psorospermin were used.Conclusion: Cytotoxicity varied with cell type, solvent and extract type used making it difficult for direct comparison of the plant species. Five of the eleven plant species namely, A. coriaria, C. sanguinolenta, G. ternifolia, P. febrifugium and Z. chalybeum had no cytotoxicity studies in animal models. For the remaining six plant species, the crude aqueous and ethanol extracts were mainly used in acute oral toxicity studies in mice. Herbalists reported only A. coriaria and W. ugandensis to cause toxic side effects in humans. However, selective cytotoxic plant extracts can potentially be beneficial as anticancer or anti-tumour drugs.

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Section: Albizia Coriaria Olivmentioning

confidence: 99%

Section: Albizia Coriaria Olivmentioning

confidence: 99%

A Review of the Toxicity and Phytochemistry of Medicinal Plant Species Used by Herbalists in Treating People Living With HIV/AIDS in Uganda

et al. 2021

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“…The Bridelia genus consists of approximately 60-70 species distributed in tropical and subtropical regions of the globe, particularly in Asia and Africa [8]. Several species of this genus have been used in traditional medicinal systems for the management of multiple diseases, including diabetes, urinary stones, lumbago, rheumatism, venereal diseases, bronchitis, gastrointestinal problems, cardiac pain, infertility, epilepsy, and diarrhoea, among others [9].…”

Section: Introductionmentioning

confidence: 99%

Bridelia speciosa Müll.Arg. Stem bark Extracts as a Potential Biomedicine: From Tropical Western Africa to the Pharmacy Shelf

et al. 2020

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Bridelia species have been used in traditional African medicine for the management of diverse human ailments. In the current work, the detailed phytochemical profiles of the extracts of the stem bark of B. speciosa were evaluated and the antioxidant and enzyme inhibitory properties of the extracts were assessed. The anti-bacterial and anti-mycotic effects of the extracts were evaluated against selected pathogen strains. Additionally, the anti-proliferative effects were studied on the liver cancer HepG2 cell line. Finally, the putative protective effects were assessed on isolated rat liver that was challenged with lipopolysaccharide (LPS). The results revealed the presence of 36 compounds in the ethyl acetate extract, 44 in the methanol extract, and 38 in the water extract. Overall, the methanol extract showed the highest antioxidant activity, particularly in LPS-stimulated rat liver. Additionally, this extract exerted the highest antimycotic effect on C. albicans, whereas the water extract showed a promising anti-proliferative effect on liver cancer HepG2 cells. The methanol extract was also the most active as enzyme inhibitor, against acetylcholinesterase and butyrylcholinesterase. The current study appraises the antioxidant and enzyme inhibition properties of B. speciosa methanol extract and showed that this specie could be a promising source of biologically active phytochemicals, with potential health uses. Supplementary Materials: The following are available online at http://www.mdpi.com/2076-3921/9/2/128/s1. Supplementary Materials and Methods; CFF-strains. Author Contributions: Conceptualization, C.F. and G.Z.; methodology, G.O.; L.M.; software, L.M.; validation,: C.F.; G.Z.; L.M.; G.O.; formal analysis, C.F.; G.Z.; investigation, K.I.S.; K.B.; S.L.; L.R.; A.C. (Annalisa Chiavaroli); S.V.; P.A.; V.H.; S.C.; R.V.; L.D.L.; A.C. (Alessandro Cama); M.C.N.P.-A.; Z.C.; J.J.; M.F.M.; resources, C.F.; G.O.; L.M.; data curation, C.F.; G.Z.; writing-original draft preparation, M.F.M.; writing-review and editing, C.F., G.Z.; G.O.; L.M.; visualization, L.B.; supervision, L.B.; project administration, C.F.; L.M.; G.O.; G.Z.; funding acquisition, C.F.; G.O.; L.M. All authors have read and agreed to the published version of the manuscript.

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“…is a deciduous shrub or a small tree of the Phyllanthaceae family (previously included in the Euphorbiaceae family). The name of the genus, "Bridelia" was derived from the name of a Swiss-German muscologist, Samuel Elisée Bridel-Brideri (1761-1828) [3,20,21]. The specific epithet "mollis" means "soft", alluding to the characteristic velvety leaves of the species [2,3,22].…”

Section: Botanical Profile Of Bridelia Mollismentioning

confidence: 99%

“…Globally, the family has 59 genera and 2 000 species [23]. Bridelia is a genus of about 60 to 70 species that have been recorded in tropical and subtropical Africa and Asia [21,24,25]. Bridelia mollis is a small deciduous tree or shrub growing not more than 8 m in height [3].…”

Section: Botanical Profile Of Bridelia Mollismentioning

confidence: 99%

Utilization of <i>Bridelia mollis</i> as herbal medicine, nutraceutical and functional food in southern Africa: A review

Maroyi¹

2019

Trop. J. Pharm Res

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Purpose: To evaluate the functional food, nutraceutical and ethnomedicinal properties of Bridelia mollis throughout its geographical range. Methods: Retrieval of information on the medicinal, nutraceutical and functional food properties of B. mollis was undertaken using electronic databases, including PubMed, EThOS, ScienceDirect, SCOPUS, ProQuest, SciFinder, Medline, Open-thesis, OATD and Google Scholar. Pre-electronic literature was sourced from the University library. Results: Literature search revealed that fresh or dried fruits of B. mollis can be commercially processed into new food products and beverages in southern Africa. Bridelia mollis is traditionally used as herbal medicine for cough, itching, fever, gastro-intestinal problems, malaria, piles, parasitic worms and wounds. Pharmacological studies on B. mollis indicate that the species has antibacterial, antifungal, antileishmanial, antioxidative and antiplasmodial properties. Conclusion: Detailed studies on the phytochemistry, pharmacological and toxicological properties of B. mollis are needed in order to establish the real nutraceutical potential benefits of the species that might improve human health.

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Ethnopharmacology and Therapeutic Value of Bridelia micrantha (Hochst.) Baill. in Tropical Africa: A Comprehensive Review

Cited by 24 publications

References 64 publications

A Review of the Toxicity and Phytochemistry of Medicinal Plant Species Used by Herbalists in Treating People Living With HIV/AIDS in Uganda

A Review of the Toxicity and Phytochemistry of Medicinal Plant Species Used by Herbalists in Treating People Living With HIV/AIDS in Uganda

Bridelia speciosa Müll.Arg. Stem bark Extracts as a Potential Biomedicine: From Tropical Western Africa to the Pharmacy Shelf

Utilization of <i>Bridelia mollis</i> as herbal medicine, nutraceutical and functional food in southern Africa: A review

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