Ethnopharmacology, Phytochemistry, Pharmacology, Toxicology and Clinical Applications of Radix Astragali

Zhang, Chunhong; Yang, Xiao; Wei, Jing-Ran; Chen, Namuhan; Xu, Jun; Bi, Ya-Qiong; Yang, Min; Gong, Xue; Li, Ziyan; Ren, Kai; Han, Qi-Heng; Zhang, Lei; Li, Xue; Ji, Minjun; Wang, Congcong; Li, Min-Hui

doi:10.1007/s11655-019-3032-8

Cited by 77 publications

(36 citation statements)

References 25 publications

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“…Based on their particular natural conditions, ecological environments, cultivation technology, and postharvest processing methods involved (Huang et al, 2011), the Midwest area of Inner Mongolia and north Shanxi Province have been considered as "daodi" areas for RA (an area producing top quality herbal medicine). While the demand for RA is increasing, its cultivation has expanded from daodi areas to many other production areas, such as Gansu, Shaanxi, Ningxia, and Hebei Provinces (Zhang et al, 2019). The cultivation area and daodi region of RA are illustrated in Figure 1.…”

Section: Introductionmentioning

confidence: 99%

“…Presently, the focus is not just on the economic benefits of a VC, but also on achieving a balance with its effect on the ecological environment and product quality. Published research shows that chemical components were identified in the RA, include saponins, flavonoids, nitrogen containing chemicals, and aminophenols (Zhang et al, 2019). Among the many compounds present in RA, astragaloside and calycosin-7-O-β-D-glucoside are considered to be the main active ingredients.…”

Section: Introductionmentioning

confidence: 99%

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Quality Control of Radix Astragali (The Root of Astragalus membranaceus var. mongholicus) Along Its Value Chains

Bao

Zhang

et al. 2020

Front. Pharmacol.

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Radix Astragali (RA), the root of Astragalus membranaceus var. mongholicus (Bunge) P.K. Hsiao, known as “Huangqi” in Chinese, has been used as a traditional herbal medicine or food in China for more than 2,000 years and is now consumed globally. Unfortunately, the increasing demand for RA has led to the overexploitation of its wild stock, as well as quality problems, including adulteration and contamination. Therefore, the sustainable cultivation of RA is urgently needed. In the present research, semi-structured interviews and key informant interviews were conducted, over a 2-year period, to collect data from stakeholders in the main production areas; moreover, a targeted chemical analysis-based quality assessment strategy was applied to understand the quality of RA. Accordingly, 10 different types of value chains (VCs) were identified in RA production; meanwhile, the contents of the main active ingredients (astragaloside and calycosin-7-O-β-D-glucoside) were analyzed by HPLC-ELSD-UV and the yield of medicinal material was demined and further analyzed using k-means clustering analysis. The results show that the tight relationship between quality of the RA and stakeholders’ revenues among the VCs, which reflects a more general trend in the production system. Over the past few decades, vertical coordination has emerged increasingly in VCs of RA, which leads to a more coherent traceability system and rigorous regulations in the supply chains. Daodi herbs can be considered to be a standard that is distinctive with good quality characteristics that emphasize the origins of the medicinal plants. We find that the suitability of geographical areas and vertical integration can improve the VCs of RA, which further contributes to its quality control, as well as its sustainable production.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Quality Control of Radix Astragali (The Root of Astragalus membranaceus var. mongholicus) Along Its Value Chains

Bao

Zhang

et al. 2020

Front. Pharmacol.

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“…AS‐IV, a triterpenoid saponin, has a moderate penetration in the blood–brain barrier and presents valid protective effects in neurological disorders. Functional or sensory loss occurs because of a multitude of advantageous features, such as antioxidant, antiviral, anti‐inflammatory, and immunoregulation functions (Costa et al, 2019; Qu et al, 2009; C. Yang et al, 2019; C. H. Zhang et al, 2019; W. D. Zhang et al, 2006). However, the majority of previous studies on AS‐IV have focused on neuroprotection during neurological diseases, while ignoring its possible effect on neurite outgrowth.…”

Section: Discussionmentioning

confidence: 99%

Positive effect of Astragaloside IV on neurite outgrowth via talin‐dependent integrin signaling and microfilament force

Wang

Zhou

Tang

et al. 2020

Journal Cellular Physiology

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Integrin plays a prominent role in neurite outgrowth by transmitting both mechanical and chemical signals. Integrin expression is closely associated with Astragaloside IV (AS-IV), the main component extracted from Astragali radix, which has a positive effect on neural-protection. However, the relationship between AS-IV and neurite outgrowth has not been studied exhaustively to date. The present study investigated the underlying mechanism of AS-IV on neurite outgrowth. Longer neurites have been observed in SH-SY5Y cells or cortical neurons after AS-IV treatment. Furthermore, AS-IV not only increased the expression of integrin β but also activated it. The AS-IV-induced increased integrin activity was attributed to the integrin-activating protein talin. Application of the actin force probe showed that AS-IV led to an increase in intracellular microfilament force during neurite growth. Furthermore, in response to AS-IV, the microfilament force was regulated by talin and integrin activity during neurite growth. These results suggest that AS-IV has the ability to increase intracellular structural force and facilitate neurite elongation by integrin signaling, which highlights its therapeutic potential for neurite outgrowth.

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“…Hs-CRP and ESR were commonly used in the laboratory to diagnose the activity of rheumatic diseases, and can be used as indicators to monitor the activity of diseases and evaluate the treatment stability. Association rules show that compared with single use Chinese traditional medicine group, XFC combined traditional Chinese medicine on IL-11, IL-17, PD-L2, hs-CRP, anti-CCP have obvious correlation, showed that after the combined traditional Chinese medicine can significantly improve the indicators, and the mechanism may be related to the pharmacological effects of XFC, semen coicis extract exerts anti-RA effects via inhibiting pro-inflammatory factors and alleviating oxidative stress [28];The active components of radix astragali can strengthened humoral and cellular immunity and improved the regulation of human immunity [29].…”

Section: Analysis Of Association Rules Between the Improvement Of Patmentioning

confidence: 99%

Screening and Verification of Key Proteins in Patients with Rheumatoid Arthritis and Intervention of Traditional Chinese Medicine

Zhang

Xin

Jiang

et al. 2020

Preprint

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Background: The aim of this study was to simultaneously and quantitatively assess the expression levels of rheumatoid arthritis (RA) proteins in serum, and explore the intervention mechanism of traditional Chinese medicine. Methods: The differences between patients and controls were investigated by Raybiotech cytokine antibody microarray. Differentially expressed proteins between two groups were then used to build receiver operator characteristic (ROC) curves. The subsequent validation with enzyme-linked immunosorbent assay (ELISA) was widened to a larger number of RA (n=40) and healthy controls (n=10).Changes of erythrocyte sedimentation rate (ESR), high-sensitivity C-reactive protein (hs-CRP), rheumatoid factors (RF) and anti-citrullinated peptide autoantibodies (anti-CCP) in patients were statistically analyzed. Results: Six proteins interleukin-2 (IL-2), interleukin-5 (IL-5), interleukin-11 (IL-11), interleukin-17 (IL-17), tumor necrosis factor-β (TNF-β), cytotoxic T lymphocyte associated antigen (CTLA)-4 were significantly up-regulated in RA compared with controls, while interleukin-8 (IL-8), programmed death-ligand 2 (PD-L2) and B7-2 were significantly down-regulated. ELISA was performed to verify the three proteins with the most significant differences, and the results consistent with the antibody chip results. The highest diagnostic accuracy using a ROC curve was observed for IL-11 with an area under the curve of 1.00. Further, after treatment, IL-11, IL-17 and PD-L2 levels regulated, and compared with the herbs group (TC), xinfeng capsule (XFC) combination with herbs (UC) more regulated. The association rule results showed that the combination of XFC with herbs significantly improved IL-11, IL-17, PD-L2 and hs-CRP. Conclusions: This study highlights the potential of antibody arrays to diagnose rheumatoid arthritis. IL-11, IL-17 and PD-L2 regulated by XFC combined with herbs.

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Ethnopharmacology, Phytochemistry, Pharmacology, Toxicology and Clinical Applications of Radix Astragali

Cited by 77 publications

References 25 publications

Quality Control of Radix Astragali (The Root of Astragalus membranaceus var. mongholicus) Along Its Value Chains

Quality Control of Radix Astragali (The Root of Astragalus membranaceus var. mongholicus) Along Its Value Chains

Positive effect of Astragaloside IV on neurite outgrowth via talin‐dependent integrin signaling and microfilament force

Screening and Verification of Key Proteins in Patients with Rheumatoid Arthritis and Intervention of Traditional Chinese Medicine

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