Ethosomes: A Novel Approach for Transdermal and Topical Drug Delivery

Kesharwani, Roohi; Patel, Dilip Kumar; Sachan, Anupam K; Kumar, Vikas; Mazumdar, Bhaskar

doi:10.5958/2321-5844.2015.00003.5

Cited by 13 publications

(8 citation statements)

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“…As a result, ethosomes are created, removing the disadvantage of trans ferosomes. Ethosomes are vesicular carriers of hydroalcoholic phospholipids with a high alcohol concentration [74]. The evapo ration of ethanol from the formulation as soon as it is applied to the skin under nonocclusive conditions causes dryness, which is one of the key downsides of ethosomes [71].…”

Section: Transethosomesmentioning

confidence: 99%

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Transethosomes: A Promising Challenge for Topical Delivery Short Title: Transethosomes for Topical Delivery

et al. 2023

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Skin provides an excellent barrier to molecular transport, as the stratum corneum is the most formidable barrier to the passage of most pharmaceuticals. Various attempts have been made to improve drug administration into the body through intact skin. Though very few routes are as attractive as the topical route, drug transport through the skin is challenging. To overcome the challenges, researchers have found a system in which the drug is encapsulated into the vesicle, penetrating deeper into the skin to hit the target site. Vesicular systems like transethosome, an ultra- deformable vesicle (UDV), tend to accumulate in the skin layers. Since transethosomes have small particle size and can easily alter the shape of vesicles compared to other vesicular systems, they can penetrate through the layers of skin. Hence, the drug encapsulated into transethosomes can easily reach the target site. Transethosomes consist of ethanol and phospholipids along with an edge activator. Ethanol and edge activator help to enhance the skin permeation of transethosomes. Various methods of preparation of transethosomes, comparison of transethosomes with other lipid vesicles, characterization of transethosomes, and application of transethosomes have been covered in this review. Transethosomes can deliver a different variety of drugs, such as anticancer, corticosteroids, proteins and peptides, analgesics

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Section: Transethosomesmentioning

confidence: 99%

“…phospholipids with a high alcohol concentration [74]. The evapo ration of ethanol from the formulation as soon as it is applied to the skin under nonocclusive conditions causes dryness, which is one of the key downsides of ethosomes [71].…”

Section: Transethosomesmentioning

confidence: 99%

Transethosomes: A Promising Challenge for Topical Delivery Short Title: Transethosomes for Topical Delivery

et al. 2023

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“…It is a non-invasive technique. 9 2. It bypasses first-pass metabolism and avoids side effects like irritation to gastric mucosa, vomiting because of unpalatable taste.…”

Section: Salient Features Of Transethosomesmentioning

confidence: 99%

“…Ethosomes are vesicular carriers consisting of hydro-alcoholic phospholipids in which concentration of alcohol is high. 9 The major disadvantage of ethosomes is that it causes dehydration of skin due to evaporation of ethanol from the formulation as soon as it is applied on skin under non-occlusive condition. 7 So transethosomes are prepared which is a combination of both transferosomes and ethosomes.…”

Section: Introductionmentioning

confidence: 99%

Nano-transethosomes: A Novel Tool for Drug Delivery through Skin

Bajaj¹,

Parab²,

Shidhaye³

2021

IJPER

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Transdermal drug delivery has become a popular tool from last few years. It overcomes drawbacks which are encountered with the oral route. Though very few routes are as attractive as transdermal route, transport of drug through the skin is challenging. In order to overcome the challenges, researchers have found a system in which the drug is encapsulated into the vesicle and these vesicles can penetrate deeper into the skin to hit the target site. Hence, better skin penetration of bioactive agents can be achieved. Vesicular systems like liposomes, niosomes, ethosomes and Transferosomes tend to remain accumulated in the skin layers. Since Transethosomes have small particle size and can easily alter the shape of vesicle as compared with other vesicular systems; it can penetrate through the layers of skin. Hence, the drug encapsulated into Transethosomes can easily reach the target site. Transethosomes consist of ethanol, phospholipids along with an edge activator. Ethanol and edge activator help to enhance skin permeation of Transethosomes. Since it is a non-invasive technique, it improves patient compliance. It also increases drug entrapment efficiency. These vesicles can accommodate different variety of drugs such as anticancer, corticosteroids, proteins and peptides, analgesics.

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“…Ethosomes are another recently developed vesicular systems able to penetrate the mammalian skin when applied both under occlusive and non-occlusive conditions 110,[114][115][116] . As transfersomes, ethosomes are composed by phospholipids and an edge activator, based in this case on alcohols such as ethanol or isopropyl alcohol, used at high concentrations ( Figure 2d) 118 .…”

Section: Ethosomesmentioning

confidence: 99%

Lipid-based nanovesicles for nanomedicine

et al. 2016

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Molecular self-assembly has enabled the fabrication of biologically inspired, advanced nanostructures as lipid-based nanovesicles (L-NVs). The oldest L-NVs, liposomes, have been widely proposed as potential candidates for drug delivery, diagnostic and/or theranostic applications and some liposome-based drug products have already stepped from the lab-bench to the market. This success is attributed to their ability to encapsulate both hydrophobic and/or hydrophilic molecules, efficiently carry and protect them within the body and finally deliver them at the target site. These positive features are also coupled with high biocompatibility. However, liposomes still present some unsolved drawbacks, such as poor colloidal stability, short shelf-life, restricted and expensive conditions of preparation because of the inherent nature of their fundamental constituents (phospholipids). The new tools available in the self-assembly of controlled molecules have significantly advanced the field of L-NV design and synthesis, and non-liposomal L-NVs have been recently developed; this new generation of nanovesicles can represent a paradigm shift in nanomedicine: they may complement liposomes, showing their advantages and overcoming most of their drawbacks. Clearly, being still young, their rocky way to the clinic first and then to the market has just started and it is still long, but they have all the potentialities to reach their objective target. The purpose of this review is to first present the large plethora of L-NVs available, focusing on this new generation of non-liposomal L-NVs and showing their similarities and differences with respect to their ancestors (liposomes). Since the overspread of a nanomaterial to the market is also strongly dependent on the availability of technological-scale preparation methods, we will also extensively review the current approaches exploited for L-NV production. The most cutting-edge approaches based on compressed fluid (CF) technologies will be highlighted here since they show the potential to represent a game-change in the production of L-NVs, favouring their step from the bench to the market. Finally, we will briefly discuss L-NV applications in nanomedicine, looking also for their future perspectives.

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Ethosomes: A Novel Approach for Transdermal and Topical Drug Delivery

Cited by 13 publications

References 0 publications

Transethosomes: A Promising Challenge for Topical Delivery Short Title: Transethosomes for Topical Delivery

Transethosomes: A Promising Challenge for Topical Delivery Short Title: Transethosomes for Topical Delivery

Nano-transethosomes: A Novel Tool for Drug Delivery through Skin

Lipid-based nanovesicles for nanomedicine

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