Ethyl .ALPHA.-D-Glucoside Increases Urine Volume and Causes Renal Morphologic Changes in Rats

Effects of ethyl-α-d-glucoside on human dermal fibroblasts

“…α-EG is excreted promptly when ingested orally, and is not accumulated in the body. 26,27) In addition, it has no remarkable toxicity, compared to the toxicity that was observed for glucose in a rat oral toxicity test. 28) Mutagenicity of purified α-EG was examined by the AMES method using Salmonella typhimurium TA 98 and 100; no mutagenicity was observed.…”

Plasma Kinetics and Urine Profile of Ethyl Glucosides after Oral Administration in the Rat

“…The intact forms of urinary EGs were determined by a modified high performance liquid chromatography (HPLC) method, as indicated in previous papers. 8,9) The HPLC system, LC-VP series (Shimadzu, Kyoto, Japan) equipped with a refractive index detector (RID-10A, Shimadzu) and a Shodex Asahipack NH 2 P-50 column (Showa Denko, Kawasaki, Japan) was used. The column was eluted under isocratic condition with 90% CH 3 CN and 10% H 2 O.…”

“…In a previous paper, we reported that -EG was transported though the rat small intestinal wall 7) and was detected in the plasma and urine of the rats fed -EG. 8,9) Some researchers have reported that -EG and -EG were transported through the small intestinal wall, 10,11) indicating that -EG ingested orally might be absorbed into blood stream through the small intestinal wall as well as -EG. Our previous study suggested that approximately 60-80% of the -EG ingested was recovered from the urine of rats within 24 h, 8,9) but changes in the plasma concentration and urine excretion of EGs after oral administration have not been investigated.…”

Safety Assessment of Decyl Glucoside and Other Alkyl Glucosides as Used in Cosmetics

“…Groups of 6 male Wistar ST rats were fed a diet for 39 days in which sucrose was replaced with 10% or 20% ethyl glucoside, and a control group was fed unaltered (ie, sucrose-containing) feed. 18 A 24-hour urine collection was made once weekly to check the volume. Approximately 60% to 90% of the ethyl glucoside ingested by treated animals was recovered in the urine.…”

“…In a study described earlier under ''Toxicokinetics,'' in which groups of 6 male Wistar ST rats were fed a diet in which sucrose was replaced with 10% or 20% ethyl glucoside for 39 days, bw gains, but not final bws, were statistically significantly decreased in the 20% group when compared to the control values. 18 All animals survived until study termination. Total water intake was increased with increased ethyl glucoside consumption.…”