Ethyl glucuronide

Wurst, Friedrich Martin; Kempter, Christoph; Metzger, Joerg; Seidl, S.; Alt, Andreas

doi:10.1016/s0741-8329(99)00076-2

Cited by 101 publications

(17 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Previous research on CM for AUDs has been limited by lack of such a biomarker. Ethyl glucuronide (EtG) is an alcohol metabolite [22–31] that can be detected in urine for up to five days after drinking and can be evaluated in a clinical setting using a benchtop analyzer [29,32–35]. Our work supports the efficacy and feasibility of an EtG-based CM intervention [36].…”

Section: Introductionsupporting

confidence: 58%

A culturally-tailored behavioral intervention trial for alcohol use disorders in three American Indian communities: Rationale, design, and methods

McDonell

Nepom

Leickly

et al. 2016

Contemporary Clinical Trials

View full text Add to dashboard Cite

Background Disproportionately high rates of alcohol use disorders are present in many American Indian/Alaska Native (AI/AN) communities, yet little information exists regarding the effectiveness of alcohol treatments in AI/AN populations. Contingency management is an intervention for illicit drug use in which tangible reinforcers (rewards) are provided when patients demonstrate abstinence as assessed by urine drug tests. Contingency management has not been widely studied as an intervention for alcohol problems because until recently, no alcohol biomarker has been available to adequately verify abstinence. Aims The HONOR Study is designed to determine whether a culturally-tailored contingency management intervention is an effective intervention for AI/AN adults who suffer from alcohol use disorders. Methods Participants include 400 AI/AN alcohol-dependent adults residing in one rural reservation, one urban community, as well as a third site to be decided, in the Western U.S. Participants complete a 4-week lead-in phase prior to randomization, then 12 weeks of either a contingency management intervention for alcohol abstinence, or a control condition where participants receive reinforcers for attending study visits regardless of alcohol use. Participants are then followed for 3-more months post-intervention. The primary study outcome is urinary ethyl glucuronide-confirmed alcohol abstinence; secondary outcomes include self-reported alcohol and drug use, HIV risk behaviors, and self-reported cigarette smoking. Discussion This will be the largest randomized, controlled trial of any alcohol for AI/ANs and the largest contingency management study targeting alcohol use disorders, thus providing important information to AI/AN communities and the alcohol treatment field in general.

show abstract

Section: Introductionsupporting

confidence: 58%

A culturally-tailored behavioral intervention trial for alcohol use disorders in three American Indian communities: Rationale, design, and methods

McDonell

Nepom

Leickly

et al. 2016

Contemporary Clinical Trials

View full text Add to dashboard Cite

show abstract

“…Thus, to improve selectivity, future use of tandem mass spectrometry (LC-MS/MS) may be preferable, although this may result in loss of sensitivity. LC-MS/MS has become used in bioanalysis due to its speed, sensitivity and specificity [29,30] with applications for a number of conjugated metabolites of ethanol and illicit drugs [31][32][33][34][35][36].…”

Section: Discussionmentioning

confidence: 99%

Determination of urinary 5-hydroxytryptophol glucuronide by liquid chromatography–mass spectrometry

Stephanson

Dahl

Helander

et al. 2005

Journal of Chromatography B

View full text Add to dashboard Cite

“…A number of alcohol biomarkers detectable within urine samples are available to supplement self-report (Litten et al, 2010). Several studies have observed that when assessed in urine, ethyl glucuronide (EtG), a minor non-oxidative hepatic metabolite of ethanol (Wurst et al, 2000), can detect alcohol use for up to five days depending on the cutoff level used and the amount of alcohol consumed (Jatlow et al, 2014; Lowe et al, 2015). Our work has demonstrated that a commercially-available EtG-immunoassay (EtG-I; Diagnostic Reagents Incorporated, Sunnyvale, CA) can be accurately conducted by non-technical staff within 20 minutes using a bench-top analyzer (Indiko, ThermoFisher, Fremont, CA) that delivers results of a semi-quantitative EtG concentration in urine (Leickly et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

Using ethyl glucuronide in urine to detect light and heavy drinking in alcohol dependent outpatients

McDonell

Skalisky

Leickly

et al. 2015

Drug and Alcohol Dependence

View full text Add to dashboard Cite

Aims This study investigated which ethyl glucuronide immunoassay (EtG-I) cutoff best detects heavy versus light drinking over five days in alcohol dependent outpatients. Methods A total of 121 adults with alcohol use disorders and co-occurring psychiatric disorders taking part in an alcohol treatment study. Participants provided self-reported drinking data and urine samples three time per week for 16-weeks (total samples = 2761). Agreement between low (100 ng/mL, 200 ng/mL), and moderate (500 ng/mL) EtG-I cutoffs and light (women ≤3 standard drinks, men ≤ 4 standard drinks) and heavy drinking (women >3, men >4 standard drinks) were calculated over one to five days. Results The 100 ng/mL cutoff detected >76% of light drinking for two days, and 66% at five days. The 100 ng/mL cutoff detected 84% (1 day) to 79% (5 days) of heavy drinking. The 200 ng/mL cutoff detected >55% of light drinking across five days and >66% of heavy drinking across five days. A 500 ng/mL cutoff identified 68% of light drinking and 78% of heavy drinking for one day, with detection of light (2–5 days <58%) and heavy drinking (2–5 days <71%) decreasing thereafter. Relative to 100 ng/mL, the 200 ng/mL and 500 ng/mL cutoffs were less likely to result in false positives. Conclusions An EtG-I cutoff of 100 ng/mL is most likely to detect heavy drinking for up to five days and any drinking during the previous two days. Cutoffs of ≥ 500 ng/mL are likely to only detect heavy drinking during the previous day.

show abstract

Ethyl glucuronide

Cited by 101 publications

References 10 publications

A culturally-tailored behavioral intervention trial for alcohol use disorders in three American Indian communities: Rationale, design, and methods

A culturally-tailored behavioral intervention trial for alcohol use disorders in three American Indian communities: Rationale, design, and methods

Determination of urinary 5-hydroxytryptophol glucuronide by liquid chromatography–mass spectrometry

Using ethyl glucuronide in urine to detect light and heavy drinking in alcohol dependent outpatients

Contact Info

Product

Resources

About