Ethyl α-D-glucoside was absorbed in small intestine and excreted in urine as intact form

Mishima, Tomoyuki; Hayakawa, T.; Ozeki, Kenji; Tsuge, Haruhito

doi:10.1016/j.nut.2004.08.024

Cited by 14 publications

(17 citation statements)

References 19 publications

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“…7) Furthermore, -EG was detected in the plasma of rats fed -EG solution as a daily drink. 8) As shown in Fig. 3, the plasma -EG concentration reached a maximal value at 1 h after oral administration, and then rapidly decreased.…”

Section: Discussionmentioning

confidence: 68%

“…The intact forms of urinary EGs were determined by a modified high performance liquid chromatography (HPLC) method, as indicated in previous papers. 8,9) The HPLC system, LC-VP series (Shimadzu, Kyoto, Japan) equipped with a refractive index detector (RID-10A, Shimadzu) and a Shodex Asahipack NH 2 P-50 column (Showa Denko, Kawasaki, Japan) was used. The column was eluted under isocratic condition with 90% CH 3 CN and 10% H 2 O.…”

Section: Methodsmentioning

confidence: 99%

“…In a previous paper, we reported that -EG was transported though the rat small intestinal wall 7) and was detected in the plasma and urine of the rats fed -EG. 8,9) Some researchers have reported that -EG and -EG were transported through the small intestinal wall, 10,11) indicating that -EG ingested orally might be absorbed into blood stream through the small intestinal wall as well as -EG. Our previous study suggested that approximately 60-80% of the -EG ingested was recovered from the urine of rats within 24 h, 8,9) but changes in the plasma concentration and urine excretion of EGs after oral administration have not been investigated.…”

mentioning

confidence: 99%

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Plasma Kinetics and Urine Profile of Ethyl Glucosides after Oral Administration in the Rat

Mishima

Harino

Sugita

et al. 2008

Bioscience, Biotechnology, and Biochemistry

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Section: Discussionmentioning

confidence: 68%

Section: Methodsmentioning

confidence: 99%

mentioning

confidence: 99%

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Plasma Kinetics and Urine Profile of Ethyl Glucosides after Oral Administration in the Rat

Mishima

Harino

Sugita

et al. 2008

Bioscience, Biotechnology, and Biochemistry

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“…More than 60% of -EG was excreted in urine in an intact form, 30) but oral ingestion of -EG reduced the epidermal barrier disruption caused by UVB irradiation in hairless mice. 17) In this study, oral ingestion of -EG suppressed GalN-induced liver injury by inhibiting the induction of IL-6.…”

Section: Discussionmentioning

confidence: 99%

“…-EG is absorbed through sodium-dependent glucose transporter-1 in the small intestine and into the bloodstream, 30) although the biodistribution of -EG is not clear. More than 60% of -EG was excreted in urine in an intact form, 30) but oral ingestion of -EG reduced the epidermal barrier disruption caused by UVB irradiation in hairless mice.…”

Section: Discussionmentioning

confidence: 99%

Hepatoprotective Effects of a Concentrate and Components of Sake against Galactosamine (GalN)-Induced Liver Injury in Mice

Izu

Hizume²,

Goto

et al. 2007

Bioscience, Biotechnology, and Biochemistry

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Identification of novel inhibitor against human phosphoethanolamine cytidylyltransferase from phytochemicals of Citrus sinensis peel extract by in vitro and in silico approach

Victor¹,

Narayanaswamy²,

Kadry³

et al. 2023

Biotech and App Biochem

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Kidney stone is a major global menace that demands research on nonsurgical treatment involving biological compounds for the benefit of the patients. Among the biological extracts, citric acid is traditionally used to dissolve kidney stones. The current research focuses on evaluating the in vitro anti‐urolithiatic activity and in silico study of ethanolic extract of Citrus sinensis (ECS) peel against c: phosphoethanolamine cytidylyltransferase (PCYT). The diuretic activity was evaluated using in vitro model against the synthesized calcium oxalate crystals and cytotoxicity study in Madin–Darby canine kidney cell lines. The phytochemicals were identified using gas chromatography–mass spectroscopy. The interaction mechanism was studied using computational docking studies to confirm their involvement in the dissolution of calcium oxalate kidney stones. Further molecular properties, drug‐likeness, ADME (absorption, distribution, metabolism, and excretion), and toxicity analysis were followed for the ligands using software tools. 5‐Hydroxymethylfurfural, 2,4‐di‐tert‐butylphenol, 2‐methoxy‐4‐vinylphenol, 6‐octen‐1‐ol, 3,7‐dimethyl‐, acetate (citronellyl acetate), 3′,5′‐dimethoxyacetophenone, and ethyl alpha‐d‐glucopyranoside showed good binding affinities against PCYT. Moreover, the docking studies showed the ligand 3′,5′‐dimethoxyacetophenone has the highest binding energy (−6.68 kcal/mol) for human CTP. The present investigation concludes that these compounds of C. sinensis peel extract compounds are responsible as novel inhibitors against human CTP and extend their use in the pharmaceutical drug development process.

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Ethyl α-D-glucoside was absorbed in small intestine and excreted in urine as intact form

Cited by 14 publications

References 19 publications

Plasma Kinetics and Urine Profile of Ethyl Glucosides after Oral Administration in the Rat

Plasma Kinetics and Urine Profile of Ethyl Glucosides after Oral Administration in the Rat

Hepatoprotective Effects of a Concentrate and Components of Sake against Galactosamine (GalN)-Induced Liver Injury in Mice

Identification of novel inhibitor against human phosphoethanolamine cytidylyltransferase from phytochemicals of Citrus sinensis peel extract by in vitro and in silico approach

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