Etiologic Factors in Aortoiliac and Femoropopliteal Vascular Disease

Friedman, Sandor A.; Holling, H. E.; Roberts, Brooke

doi:10.1056/nejm196412312712702

Cited by 30 publications

(15 citation statements)

References 3 publications

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“…Therefore the age at the onset of menopause is the most important determinant of LEAOD affliction among reproductive factors. These findings are in complete agreement with other studies with direct consideration of menopause [7,12,16,19,20].…”

Section: Discussionsupporting

confidence: 93%

“…The incidence of such diseases has been found to be much lower among premenopausal women than among men in the same age group; this effect dissipates once women reach menopause. Friedman [7] found that 50% of women with aortoiliac occlusions had experienced surgical menopause. Such observations have motivated the study of the relationship between estrogen levels and coronary heart disease, indicating that endogenous estrogens may protect women from coronary heart disease.…”

Section: Introductionmentioning

confidence: 99%

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Reproductive factors and lower extremity arterial occlusive disease in women

Holzer

Koschat

Kickinger³

et al. 2007

Eur J Epidemiol

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Section: Discussionsupporting

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Reproductive factors and lower extremity arterial occlusive disease in women

Holzer

Koschat

Kickinger³

et al. 2007

Eur J Epidemiol

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“…Of the 3 women presenting with gangrene, I had a plasma cholesterol of 280 mg. per cent and I had in the past undergone a hysterectomy. In a series of 43 patients with aorto-iliac disease Friedman, Holling, and Roberts (1964) reported that 28 per cent of their patients were women and of these 6 had undergone hysterectomy. This, they suggested, implied a hormonal imbalance as a common aetiological factor both for their atherosclerosis and their uterine disorder.…”

mentioning

confidence: 99%

Aorto-iliac thrombo-endarterectomy

Spiro

Cotton

1970

Journal of British Surgery

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A series of 46 patients, all of whom underwent thrombo‐endarterectomy for occlusive atherosclerotic disease of the abdominal aorta and iiiac arteries, is presented. The operative mortality of the whole series is 10 per cent but in the last 32 cases only 3 per cent. This compares favourably with other published series and other reconstructive procedures. The follow‐up ranges from 6 months to 9 years and averages 2 years 6 months in the 42 postoperative survivors. In this group the patency rate is 90 per cent. The incidence and causation of impotence post‐operatively are discussed and measures suggested for avoiding this complication. Emphasis is laid on the anatomical distribution of the atheroma and its haemodynamic effects as determining factors in the prognosis and the suitability of this disease for treatment by thrombo‐endarterectomy. Further advance in the operative treatment of atherosclerosis of the great abdominal vessels should continue to take an ever‐increasing account of the perfusion and flow problems intimately associated with the disease and its relief.

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“…In 1964, Friedman et al [28] observed that 6 of 12 consecutive women with aortoiliac occlusions had experienced artificial menopause. Weiss [29] examined operative records over 24 years among nondiabetic women with lower extremity atherosclerosis who underwent surgical revascularization.…”

Section: Menopausementioning

confidence: 99%

Peripheral Arterial-Vascular Disease in Women: Prevalence, Prognosis, and Treatment

1995

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Lower extremity atherosclerosis results in significant morbidity in women, particularly in women following the menopause. Up to 25% of women aged 55 to 74 years are affected by this disease. When noninvasive testing is used to determine the prevalence of lower extremity atherosclerosis, and men in this age group are equally represented. Cigarette smoking, diabetes mellitus, and menopause are risk factors for atherosclerosis of particular interest in women. The prevalence of cigarette smoking is rising rapidly among women, and diabetes appears to be a greater risk factor for atherosclerosis in women than in men. Risk factor reduction, in addition to an exercise program, are important parts of the treatment program for stable claudication. In both men and women with more severe symptoms, an ankle/brachial index (ABI) of less than 0.3 is associated with a poor prognosis. Men and women fare equally well following revascularization for severe peripheral atherosclerosis. However, there are some data to suggest that women may be offered peripheral revascularization at a lower rate.

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Etiologic Factors in Aortoiliac and Femoropopliteal Vascular Disease

Cited by 30 publications

References 3 publications

Reproductive factors and lower extremity arterial occlusive disease in women

Reproductive factors and lower extremity arterial occlusive disease in women

Aorto-iliac thrombo-endarterectomy

Peripheral Arterial-Vascular Disease in Women: Prevalence, Prognosis, and Treatment

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