Reproductive factors and lower extremity arterial occlusive disease in women

Holzer, Gerold; Koschat, Martin A.; Kickinger, Wolfgang; Clementi, Wolfgang; Holzer, Lukas A.; Metka, M.

doi:10.1007/s10654-007-9156-8

Cited by 4 publications

(3 citation statements)

References 26 publications

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“…Short reproductive lifespan was associated with increased risk of stroke events (RR 1.31, 95% CI 1.25–1.36; heterogeneity I 2 = 0%, P = 0.331) 5,6,42 . There was no evidence for an association of short reproductive lifespan with CVD mortality (RR 1.02, 95% CI 0.89–1.15; heterogeneity I 2 = 0%, P = 0.543) 25,26,43,44 and all‐cause mortality (RR 1.00, 95% CI 0.81–1.19; heterogeneity I 2 = 75.3%, P = 0.007) 27,28,30,33 (see Supplementary material, Figure S1). Similarly, early age at menarche (RR 1.17, 95% CI 0.20–2.14; heterogeneity I 2 = 69.6%, P = 0.070) 5,19 and early age at menopause (RR 1.13, 95% CI 0.71–1.56; heterogeneity I 2 = 22.9%, P = 0.255) 5,19 were not significantly associated with moderately higher risk of stroke events.…”

Section: Resultsmentioning

confidence: 99%

Duration of estrogen exposure during reproductive years, age at menarche and age at menopause, and risk of cardiovascular disease events, all‐cause and cardiovascular mortality: a systematic review and meta‐analysis

Mishra

Chung

Waller

et al. 2020

BJOG

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Background Little is known about the estrogen exposure measurement and mutual effect of age at menarche and age at menopause in the risk of cardiovascular disease (CVD) events. Objectives To evaluate estrogen exposure measurement and describe mutual effect of age at menarche and age at menopause in the risk of CVD events. Search strategy Systematic review of literature in PubMed, Embase and Web of Science for studies published up to 28 June 2020. Selection criteria Observational studies related to estrogen exposure measurement, including mutual effect of age at menarche and age at menopause and risk of CVD events. Data collection and analysis Synthesis of evidence was conducted by reviewing individual estimates, followed by meta‐analysis. The study received no external funding. Main results A total of 75 studies were included in synthesis of evidence, of which 17 studies were included in meta‐analysis. Reproductive lifespan (age at menopause – age at menarche), endogenous estrogen exposure and total estrogen exposure were used for estrogen exposure measurement. Reproductive lifespan was by far the most commonly used method for estrogen exposure measurement. A shorter reproductive lifespan was associated with a higher risk of CVD events; the pooled relative risk (95% CI) was 1.31 (1.25–1.36) for stroke events. Robust epidemiological studies with measurement of estrogen exposure and associated health risk would strengthen the evidence. Conclusions Reproductive lifespan was the most commonly used method for estrogen exposure measurement in epidemiological studies. A shorter reproductive lifespan was associated with a higher risk of CVD events, particularly stroke. Tweetable abstract A systematic review and meta‐analysis found that women with a shorter reproductive lifespan have a higher risk of stroke events.

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Section: Resultsmentioning

confidence: 99%

Duration of estrogen exposure during reproductive years, age at menarche and age at menopause, and risk of cardiovascular disease events, all‐cause and cardiovascular mortality: a systematic review and meta‐analysis

Mishra

Chung

Waller

et al. 2020

BJOG

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“…As a common manifestation of systemic atherosclerosis in the limbs, the incidence of LEAOD has undergone a significant increase in recent years, and an interventional treatment called PTA has arisen as a promising treatment for LEAOD [3,5]. However, there are still some complications after interventional treatment, particularly vascular restenosis.…”

Section: Discussionmentioning

confidence: 99%

“…The growth of secondary thrombosis or atherosclerotic material can result in stenosis or occlusion of the arterial lumen, clinically presenting as a limb blood circulation disorder with which patients can easily suffer gangrene or ulcers [2]. LEAOD mainly occurs in patients over the age of 40, and the incidence was higher in men than in women, ascending with increased age while the incidence of claudication in women aged over 50 years approaches that of men [3]. LEAOD usually causes embolism, thrombus formation or stenosis, leading to acute or chronic ischaemia of the lower limbs.…”

Section: Introductionmentioning

confidence: 99%

Circulating mircoRNA-21 as a predictor for vascular restenosis after interventional therapy in patients with lower extremity arterial occlusive disease

et al. 2017

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The present study was designed to investigate the role of circulating miRNA-21 (miR-21) in vascular restenosis of lower extremity arterial occlusive disease (LEAOD) patients after interventional therapy. A total of 412 LEAOD patients were enrolled randomly in the present study. According to computed tomography angiography (CTA) and ankle-brachial index (ABI), patients were assigned into the restenosis group and the non-restenosis group. miR-21 expression was detected with quantitative real-time PCR (qRT-PCR) before and after patients underwent interventional therapy. A follow-up period of 6 months was achieved. A receiver operating characteristic (ROC) curve was drawn and the area under the curve (AUC) was calculated to assess the predictive value of miR-21 in vascular restenosis. Patients were older in the restenosis group than in the non-restenosis group. The percentages of patients with diabetes and hypertension were higher in the restenosis group than in the non-restenosis group, and the Fontaine stage exhibited a significant difference between the two groups. miR-21 expression was higher in the restenosis group than in the non-restenosis group. miR-21 expression level was related to age, diabetes and hypertension in the restenosis group. Using miR-21 to predict vascular restenosis yielded an AUC of 0.938 (95% confidence interval (CI): 0.898–0.977), with Youden index of 0.817, sensitivity of 83.5% and specificity of 98.2%. Logistic regression analysis revealed that diabetes and miR-21 expression were the major risk factors for vascular restenosis of LEAOD. miR-21 can be used as a predictive indicator for vascular restenosis of LEAOD after interventional therapy.

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Reproductive factors and its association with peripheral arterial disease in women aged 52–81 years: The KORA F4 study

et al. 2013

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Reproductive factors and lower extremity arterial occlusive disease in women

Abstract: We established a distinct relationship between reproductive variables, such as length of fertile period and age at menopause, and the development of severe LEAOD. The relations that we found are, by and large, consistent with other findings on similar ailments.

Cited by 4 publications

References 26 publications

Duration of estrogen exposure during reproductive years, age at menarche and age at menopause, and risk of cardiovascular disease events, all‐cause and cardiovascular mortality: a systematic review and meta‐analysis

Duration of estrogen exposure during reproductive years, age at menarche and age at menopause, and risk of cardiovascular disease events, all‐cause and cardiovascular mortality: a systematic review and meta‐analysis

Circulating mircoRNA-21 as a predictor for vascular restenosis after interventional therapy in patients with lower extremity arterial occlusive disease

Reproductive factors and its association with peripheral arterial disease in women aged 52–81 years: The KORA F4 study

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