Etiological, Clinical and Prognostic Significance of the T-B Immunological Classification of Primary Acute Lymphoid Leukemias and Non Hodgkin’s Lymphomas

Belpomme, D.; Lelarge, N.; Mathé, G; Davies, A.C.

doi:10.1007/978-3-642-66639-1_4

Cited by 15 publications

(1 citation statement)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Conventional cell-marking methods us ing rosette techniques and heteroantisera have proved to be helpful tools, especially in the characterization and classification of malignant non-Hodgkin lymphomas (NHL) [1-4, 10, 12, 27] and acute lympho blastic leukemia [2,6,10,28]. Further more, the development and invention of monoclonal antibodies (mAbs) derived from hybridomas [16] have been helpful in elucidating the mechanisms of lympho cyte differentiation as well as the cellular basis of malignant lymphoma.…”

Section: Introductionmentioning

confidence: 99%

Dual Expression of T and B Cell Markers in Human B Cell Neoplasias

Herrmann¹,

Lochner²,

Enders³

et al. 1983

Acta Haematol

View full text Add to dashboard Cite

Macrophage- and T-cell-depleted mononuclear cells from 36 patients with B cell lymphoma and 12 healthy individuals were investigated by indirect immunofluorescence with the monoclonal antibodies NEI-011 (7.2) and NEI-015 (10.2). The monoclonal antibody NEI-011 (7.2) recognized the la antigen and identified almost all B cells in the peripheral blood of healthy individuals. Furthermore, neoplastic B cells from all patients except those with plasma cell proliferation were found to react with this antibody. NEI-015 (10.2), a monoclonal antibody known to react with both T cells and B-CLL cells, did not react with normal circulating B cells. However, this antibody did identify neoplastic B cells except in cases of plasma cell proliferation and lymphoblastic lymphoma.

show abstract

Section: Introductionmentioning

confidence: 99%

Dual Expression of T and B Cell Markers in Human B Cell Neoplasias

Herrmann¹,

Lochner²,

Enders³

et al. 1983

Acta Haematol

View full text Add to dashboard Cite

show abstract

Predictability of immunologic phenotype of malignant lymphomas by conventional morphology. A study of 60 cases

Frizzerà

Gajl‐Peczalska

Bloomfield

et al. 1979

Cancer

View full text Add to dashboard Cite

In order to test the immunologic validity of the Lukes-Collins (L-C) classification of the non-Hodgkin's lymphomas (ML), 60 ML in adult patients were studied and their B- or T-cell nature was predicted on a morphologic basis, without knowledge of the clinical history or the results of surface marker (SM) studies (SIg, C', Fc and E-rosettes), which were performed on cell suspensions and cryostat sections from the same specimens used for histology. There was a good correlation between morphologic types and SM (97% for the nodular ML, 81% for the diffuse). The predictions were not confirmed in 6 instances: one nodular ML typed as T; one convoluted lymphocytic ML typed as histiocytic; and four diffuse ML, predicted to be of B-type, bore no detectable SM ("Null" ML). It is concluded that the L-C morphologic criteria do allow in most cases the recognition of the B- or T-cell nature of ML, but cannot detect variations of the SM pattern which seem to affect the clinical behavior of these neoplasias. Thus, while the L-C classification seems immunologically sound, its clinical relevance still needs to be demonstrated.

show abstract

A critical analysis of the classifications of non-Hodgkin's lymphomas

Nathwani

1979

Cancer

131

View full text Add to dashboard Cite

The Rappaport classification of non-Hodgkin's lymphomas was proposed almost a quarter century ago, before the advent of modern immunology. This classification, which is based entirely on morphologic features, has proved its clinical usefulness. In light of recent scientific advances, however, its terminology is not appropriate. Five new classifications have been proposed recently, each claiming to have more merit than the others. The purpose of this study is to critically analyze and evaluate these newly proposed classifications to determine which classification is conceptually and scientifically acceptable as well as clinically useful. The results of the study show that there are more similarities than differences among the Rappaport. Lukes and Collins, Dorfman, British, and WHO classifications; the Kiel classification, however, is fundamentally different (Tables 8, 9, 11). None of these classifications can be used in its proposed form. Based on the analysis of these classifications, a compromise working classification is proposed which incorporates the relevant concepts and terminology from the Rappaport, Berard, Dorfman, WHO, and Lukes and Collins classifications (Tables 15, 16). The proposed compromise classification is an attempt to reconcile the various classifications, and to stimulate others to offer modifications which may bring about a final solution to the problem of classification of non-Hodgkin's lymphomas.

show abstract

Etiological, Clinical and Prognostic Significance of the T-B Immunological Classification of Primary Acute Lymphoid Leukemias and Non Hodgkin’s Lymphomas

Cited by 15 publications

References 32 publications

Dual Expression of T and B Cell Markers in Human B Cell Neoplasias

Dual Expression of T and B Cell Markers in Human B Cell Neoplasias

Predictability of immunologic phenotype of malignant lymphomas by conventional morphology. A study of 60 cases

A critical analysis of the classifications of non-Hodgkin's lymphomas

Contact Info

Product

Resources

About