Etiological factors of preterm delivery

Brkičević, Elvira; Grgić, Gordana; Ljuca, Dženita; Ostrvica, Edin; Tulumović, Azur

doi:10.17532/jhsci.2013.81

Cited by 3 publications

(3 citation statements)

References 10 publications

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“…Genital tract infection in pregnancy is significantly associated with preterm delivery. 10,19,20 The condition can be caused by sexually transmitted pathogens such as Chlamydia trachomatis, Neisseriagonorrhoeae, and Trichomonas vaginalis and by the imbalance of vaginal normal flora. The imbalance of normal flora in the vagina often leads to a condition called bacterial vaginosis that affects 4.5-50% of the women population worldwide and 134 million women have vulvovaginal candidiasis.…”

Section: Discussionmentioning

confidence: 99%

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The role of genital tract infection inpreterm delivery: aretrospective study

2019

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Preterm delivery is associated with higher mortality and morbidity of neonates, also increasestheir risk of having growth and development impairment.This study aimed toidentify the role ofgenital tract infection in preterm delivery. A retrospective study was conducted on medical records of mothers who had preterm delivery in a tertiary hospital in Surakarta, Indonesia during 2017. The data collected were mothers' age and their gestational age, the history of current pregnancy, the number of previous abortion(s), mothers' body temperature, the extent of abnormal vaginal discharge, and laboratory findings (white blood cell count, platelet count, red blood cell count, hemoglobin count, hematocrit level, urinalysis and microbiology results). The statistical differences amongst categorical and numerical data were analyzed using the Chi-Square test and the Mann-Whitney test. Based on the patient's history and the examination results, we suspected genital tract infections in22.52% (25/111)of subjects. All of them had abnormal vaginal discharge despite only one case had been confirmed as streptococcal infection. This study found that the majority of mothers with probable genital tract infection hadpreterm premature rupture of the membrane whilst preeclampsiawas more evident in those without genital tract infection. We conclude that genital tract infection during pregnancy is a significant contributor to the occurence of premature birth so that microbiological testing is needed to confirm the diagnosis. ABSTRAK Kelahiran preterm berkaitan dengan meningkatnya mortalitas dan morbiditas neonatus, serta meningkatkan risiko terjadinya kelainan tumbuh kembang. Penelitian ini bertujuan untuk mengidentifikasi peranan infeksi saluran genital terhadap kelahiranpreterm. Penelitian dilakukan secara retrospektif menggunakan data rekam medis dari ibu-ibu yang melahirkanpreterm di sebuah rumah sakit tersier di Surakarta, Indonesia pada tahun 2017. Data yang dikumpulkan adalah usia ibu dan usia kehamilan,riwayat kehamilan saat ini, jumlah abortus sebelumnya, suhu tubuh ibu hamil, adanya keputihan yang abnormal, dan hasil pemeriksaan laboratorium (hitung sel darah putih, hitung trombosit, hitung sel darah merah, hitung hemoglobin, kadar hematokrit, urinalisis, dan hasil pemeriksaan mikrobiologi).Perbedaan statistik yang ada padadata kategorikal dan numerik dianalisis menggunakan uji Chi-Square dan uji Mann-Whitney. Berdasarkan data hasil anamnesis dan pemeriksaan, 25 dari 111 subjek penelitian (22,52%) diduga menderita infeksi saluran genital. Pasien yang terduga infeksi tersebut seluruhnya mengalamikeputihan yang abnormal meskipun hanya satu kasus yang terdiagnosis infeksi streptokokus. Pada penelitian ini didapatkan ketuban pecah dini preterm pada mayoritas ibu hamil yang dicurigai menderita infeksi saluran genital sedangkan preeklampsia lebih banyak dijumpai pada kelompok ibu hamilyang tidak terinfeksi. Dapat disimpulkan bahwa infeksi saluran genital berperan penting dalam terjadinya kelahiran prematur sehingga pemeriksaan mikrobiologi...

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Section: Discussionmentioning

confidence: 99%

“…The condition itself is responsible for the 35% of the preterm delivery cases. 10 Non-infectious conditions that account for preterm delivery include multiple gestation, polyhydramnios, and preeclampsia. 11,12 The mechanism contributing to preterm delivery in a non-infectious state is similar to that inan infectious statei.e.…”

Section: Introductionmentioning

confidence: 99%

The role of genital tract infection inpreterm delivery: aretrospective study

2019

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“…In at least 35% of women with preterm delivery, contraction happened after the membranes rupture. 75,82 PPROM is a pre-labor rupture of the membranes occurring before 37 weeks of gestation. Infection is responsible for about 55% of PPROM by promoting the release of proinflammatory cytokines.…”

Section: Immune Activation and Inflammatory Responses In Preterm Delivery Early Uterine Contractionmentioning

confidence: 99%

Genital Tract Infection during Pregnancy and its Association with Preterm Delivery

Susilawati¹,

Satria²

2021

IJTID

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Genital tract infection (GTI) remains a significant health concern. It is estimated that in 2016, there were 370 million people who suffer from chlamydia, gonorrhea, and trichomoniasis; and 708 million others suffer from genital herpes and condyloma acuminatum. It has been reported that in pregnant women, GTI is associated with preterm delivery. The mechanisms of GTI-associated preterm delivery need to be further understood to prevent neonatal mortality and morbidity that could be the risk factor for neonates’ growth and development disorders. This article aims to describe various types of GTI and the associated pathogenesis causing preterm birth. A literature search was conducted to retrieve recent articles published in English from online databases including Pubmed, ScienceDirect, and Google Scholar. This literature study found that GTI evokes inflammatory responses that trigger several mechanisms leading to preterm delivery. The inflammatory responses in GTI include the production of proinflammatory cytokines and robust activation of neutrophils. The key mechanisms that stimulate preterm delivery in GTI include the events of early uterine contraction, preterm premature rupture of membranes, and induction of cervical ripening; which are under normal circumstances in a full-term pregnancy, those mechanisms are regulated by progesterone and prostaglandin levels along with suppression of the inflammatory responses. In conclusion, this paper has described the underlying mechanisms of preterm delivery in pregnant women with ISG. However, such mechanisms remain unclear in candida and gonococcal infection; thus, prompting the need for further studies.

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The Risk Factors and Prediction Models of Preterm Birth: An Update Systematic Literature Review

Wathan¹,

Siregar²

2021

IJPHRD

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Background: Every year there is an increase in preterm births in the world, and for this condition, Indonesia occupies the highest position in ASEAN, with 15.5% of live births. The purpose of this study is to find for risk factors and prediction models to detect preterm birth.Method: This study is conducted in multistage process following PRISMA guidelines with the inclusion criteria as follow, a) search for academic journals in the online database of ProQuest, Ebsco, PubMed, SpringerLink and Science Direct, b) publications in the last 10 years (2009-2019), c) articles in English, and d) the article contains outcome in the form of risk factors and prediction models for preterm birth e) the population is pregnant women suspected of having risk factors for preterm birth.Results: From the 1767 articles found in 5 online databases, only 16 articles fall into the PICOS categories and are discussed in this paper. This study identified some of the most dominant risk factors for the incidence of preterm birth, including demographic and socioeconomic, behavioral characteristics/life style, maternal health/chronic conditions, current fetal conditions/pregnancy characteristics, pregnancy history/genetic characteristics, biological characteristics and others. This study concludes that maternal age and previous preterm birth are the factors that always used by the researchers. For the prediction of preterm birth, many researchers include cervical length as a predictor.Conclusions: Previous researches were more still focused on risk factors and not much about prediction models. Therefore, this study suggests that the upcoming research should put more emphasis on risk prediction model for detecting preterm birth.

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Etiological factors of preterm delivery

Cited by 3 publications

References 10 publications

The role of genital tract infection inpreterm delivery: aretrospective study

The role of genital tract infection inpreterm delivery: aretrospective study

Genital Tract Infection during Pregnancy and its Association with Preterm Delivery

The Risk Factors and Prediction Models of Preterm Birth: An Update Systematic Literature Review

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