Etiological Profile of Plasmacytosis on Bone Marrow Aspirates

Gupta, Monika; Malik, Shivani; Kalra, Rajnish; Sharma, Nisha; Singh, Sunita; Gupta, Veena; Jain, Promil; Sen, Rajeev

doi:10.5798/diclemedj.0921.2016.01.0628

Cited by 3 publications

(4 citation statements)

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“…The commonest presentation in myeloma patients was generalized weakness followed by bone pains. Bone pains was also the second most common symptom in a study done by M.Gupta etal 5 . Plasma cell concentration ranged from 8% to 86%.Neoplastic plasma cells are diagnosed based on morphology, protein electrophoresis and immunophenotyping.…”

Section: Discussionmentioning

confidence: 93%

Diagnostic Outcome of Bone Marrow Aspiration– An Experience from Tertiary Care Hospital

Manzoor¹

2018

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Background: Bone marrow examination is a useful tool not only in determining the cause of disease but also helpful in establishing definitive diagnosis in most of the cases. It is relatively safe procedure which can be performed on outpatient basis. Objectives: To study the spectrum of lesions on bone marrow aspiration. Methods: The study was conducted in the department of hematopathology in collaboration with department of clinical hematology, Sher-I -Kashmir Institute of medical sciences (SKIMS), Soura, Srinagar. The study was conducted over a period of 4 years from Jan 2010-Dec 2014. It was a 3 years retrospective and 1 year prospective study. Retrospective data was collected from record section of department of hematopathology. For prospective cases patients were enrolled for the procedure after screening from clinical departments. Results: In present study 5287cases of bone marrow aspirations were done over a period of 4 years. Malignant cases (33.55%) outnumbered benign cases (26.78%). Nutritional anemia was the commonest lesion among benign cases. Acute leukemia's was commonest lesion among malignant cases. Conclusion: Bone marrow examination is a valuable test in diagnosis hematological disorders and to some extent in nonhematological disorders.

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Section: Discussionmentioning

confidence: 93%

Diagnostic Outcome of Bone Marrow Aspiration– An Experience from Tertiary Care Hospital

Manzoor¹

2018

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“…The multifactorial mechanism causing proliferation of plasma cells could be considered as a defence response mechanism to the underlying disease processes due to increased release of paracrine growth factors such as cytokines, IL-6 or IL-10. [5] It has been substantiated that various viral infections including Hepatitis A, Epstein-barr, Dengue and Parvovirus B 19 are associated with reactive plasmacytosis. However, PCM is a rare disease, and its exact etiology is not yet known, it is generally reported in patients' with previous history of immunologically mediated disease like Sjögren syndrome or possible autoimmune hepatitis.…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, it is necessary to perform more speci c investigations in order to achieve an appropriate diagnosis and obtain better clinical management. [5] Thus, here we describe a rare case report of a patient that presented with a papillary overgrowth as a manifestation of HPV induced reactive plasmacytosis.…”

Section: Introductionmentioning

confidence: 88%

Viral Induced Reactive Plasmacytosis

Bhatnagar,

Joshi,

Morya

et al. 2024

Preprint

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Plasmacytosis is a condition of increased number of plasma cells in tissues, exudate or blood as a defence mechanism. Transient immune reactions in any infection or autoimmune disorder may present as reactive plasmacytosis that might rarely also manifest as plasma cell mucositis. Reactive plasmacytosis has been reported in several viral infections and has been found to completely disappear within 2 weeks. Complete clinical evaluation, individualised investigation and more specific tests are required to rule out these oral manifestations. Thus, we hereby present an extremely rare condition wherein Human Papilloma Virus (HPV) led to reactive plasmacytosis.

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“…The pluripotency of hematopoietic stem cells can be any cell type in the bloodstream. Under the influence of tissue and hormonal factors, in parallel with the differentiation or maturation process, these cells turn into the cells we know in the bloodstream (1).…”

Section: Introductionmentioning

confidence: 99%

Chromosomal Anomalies in Bone Marrow Samples of Patients Diagnosed with Hematological Cancer: FISH Results of 109 Cases from one Center

ÇALIŞKAN

Balkan

Tekeş

et al. 2022

Ege Tıp Bilimleri Dergisi

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AMAÇ: Hematolojik kanserler, kemik iliği, kan ve lenf düğümlerini etkileyen genellikle yapısal ve sayısal kromozom anomalileri ile ilişkili bir neoplazma grubudur. Hematolojik kanserlerde kemik iliği incelemesi, hastalığın tanısı ve prognozu hakkında aydınlatıcı ve yönlendirici bir role sahiptir. Çalışmamızda, hematolojik kanser tanılı hastalarda belirli genetik düzensizliklerin Floresan In Situ Hibridizasyon (FISH) yöntemi kullanılarak elde edilen sonuçlarının retrospektif olarak değerlendirilmesi amaçlanmıştır. GEREÇ ve YÖNTEM: Çalışmamızda,1 Ocak 2021-30 Kasım 2021 tarihleri aralığında, Dicle Üniversitesi Tıp Fakültesi Tıbbi Biyoloji ve Genetik Anabilim Dalı'na, Hematoloji anabilimdalı ve diğer kliniklerden yönlendirilen hematolojik kanser ön tanılı 109 hastanın (KML n=14, AML n=40, KLL n=6, ALL n=27, M.Myelom n=22) kemik iliği örneklerinden FISH yöntemi kullanılarak elde edilen sonuçları yaş, cinsiyet, hastalık dağılımı açısından retrospektif olarak incelenmiştir. Çalışma grubuna alınan hastaların tümü kromozomal anomaliler, sayısal ve yapısal değişlikler ya da dengeli translokasyon varlığı açısından değerlendirilmiştir. BULGULAR: Olguların 47’si kadın 62’si erkek hasta olup yaş ortalaması 48±21,6 olarak tespit edildi. Olguların incelenmesi sonucunda, AML için bilinen; t(15;17), monozomi 7 ve trizomi 8, KML için t(9;22); KLL de del(13q14) ve del(17p13), M.Myelom için t(11;14)(q13;q32), ALL için (t[9;22]) (bcr-abl) ve t(4;11) gibi yapısal ve sayısal kromozom değişiklikleri ilk olarak gösterilmiștir. Ayrıca grupların karşılaştırılmasında kadın erkek incelemeye katılan materyaller arasında anlamlı fark bulunamamıştır. TARTIŞMA ve SONUÇ: FISH yöntemi ile hematolojik kanser ön tanısı almış hastalarımızla yaptığımız bu retrospektif çalışmada hastalıklarla ilişkili prognostik olarak önemli anomaliler ile ilgili sonuçlarımızı değerlendirdik. Hastalıkların tanılarının hızlı ve doğru olarak tespitinin hastalığın tedavi planlaması ve seyrinin ön görüsü açısından çok önemlidir. Sonuç olarak bizim çalışma sonuçlarımıza göre kısıtlı ve zor şartlarda alınan kemik iliklerinden hücre elde etmenin zorluğu göz önüne alındığında FISH yönteminin interfaz hücrelerinde bile çalışma imkanı sağlaması nedeniyle kanser genetiğinde kullanılan güçlü ve etkili bir teknik olduğu kanaatine varılmıştır.

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Etiological Profile of Plasmacytosis on Bone Marrow Aspirates

Cited by 3 publications

References 5 publications

Diagnostic Outcome of Bone Marrow Aspiration– An Experience from Tertiary Care Hospital

Diagnostic Outcome of Bone Marrow Aspiration– An Experience from Tertiary Care Hospital

Viral Induced Reactive Plasmacytosis

Chromosomal Anomalies in Bone Marrow Samples of Patients Diagnosed with Hematological Cancer: FISH Results of 109 Cases from one Center

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