Etiological role and molecular-genetic features of &lt;i&gt;Streptococcus pneumoniae&lt;/i&gt; in children’s infectious diseases

Протасова, И. Н.; Мартынова, Г. П.; Ильенкова, Н. А.; Kutischeva, I. A.; Domracheva, S. V.; Овчинникова, О П; Sokolovskaya, E. S.

doi:10.22627/2072-8107-2020-19-1-7-12

Cited by 2 publications

(1 citation statement)

References 7 publications

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“…Микробиологические исследования включали определение серотипов культур пневмококка, полу ченных от детей, госпитализированных в стациона ры г. Красноярска с внебольничной пневмонией (n = 120), острым гнойным средним отитом (n = 85) и гнойным бактериальным менингитом (n = 17) [16]. Исследования проводились с использованием куль турального и молекулярного (ПЦР) методов [16]. Анализ этиологической структуры заболеваемости проводился как по данным собственных исследова ний, так и по данным стационаров.…”

Section: коэффициент корреляции рассчитывали с помо щью Ms Excel по формуле: рисунок 7 динамика заболеваемости детей осо до начала массовunclassified

Preventive Efficacy of Pneumococcal Conjugated Vaccine (Population Aspects)

Протасова

Фельдблюм

Бахарева³

et al. 2022

Epidemiology and Vaccinal Prevention

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Relevance. Pneumococcal disease remains an urgent public health problem, despite mass immunization of infants and young children. The impact of children’s universal vaccination on the morbidity and etiological structure in various clinical forms of infection remains unclear in children and adults. Аim. Тo evaluate the herd effect of children’s mass immunization with a 13-valent conjugated pneumococcal vaccine. Materials and Methods. The prophylactic efficacy of mass vaccination is studied within comparative retrospective epidemiological analysis of incidence rates and etiological structure of bacterial meningitis, ear diseases and mastoiditis, and community-acquired pneumonia in children and adults of Krasnoyarsk region in the pre- and post-vaccination periods, according to the official statistics and microbiological monitoring. Results. The changes in decrease of incidence rates with all clinical forms of pneumococcal infection except community-acquired pneumonia are revealed both in children and adults during mass immunization. Etiological structure changes and also changes of S. pneumoniae serotype distribution are detected in major clinical forms of infection. Conclusion. Reducing the incidence rates in children is determined predominantly by vaccinal prevention. The observed decrease of incidence rates in adults is the result of reducing the number of pneumococcal infection sources among children (herd immunity).

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Preventive Efficacy of Pneumococcal Conjugated Vaccine (Population Aspects)

Протасова

Фельдблюм

Бахарева³

et al. 2022

Epidemiology and Vaccinal Prevention

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Analysis of pneumococcal serotypes distribution to determine a model composition for a Russian pneumococcal conjugate vaccine

Трухин¹,

Evtushenko²,

Салимова³

et al. 2022

Biological Products. Prevention, Diagnosis, Treatment

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Diseases caused by Streptococcus pneumoniae, as well as antibiotic resistance of its serotypes, are the leading cause of death amongst children worldwide. To prevent pneumococcal infection, the population is immunised with conjugate vaccines containing different amounts of polysaccharides of certain serotypes. Development of a full-cycle Russian vaccine is vital because the active pharmaceutical ingredients for the vaccines registered in the Russian Federation are produced abroad, and only the final stages of production of vaccines of this group are performed in the territory of the Russian Federation. Considering the phenomenon of serotype replacement associated with the long-term widespread use of pneumococcal conjugate vaccines, it is necessary to carefully select the serotype composition for the new vaccine. The aim of this work was to analyse the serotype distribution of pneumococci in the Russian Federation and other countries in order to select optimal serotypes for the Russian vaccine for human use, taking into account vaccination schedules for each age group. This review presents an analysis of the pneumococcal serotype distribution in the Russian Federation in the pre-vaccination era, as well as after the introduction of routine vaccination. In addition, the review includes data on the serotype distribution in the Eurasian Economic Union countries. The authors described a model composition containing at least sixteen serotypes. It will increase effectiveness of immune protection of the population, providing a more complete coverage of serotypes, considering their prevalence in the Russian Federation. Based on the analysis, the serotype composition for the sixteen-valent pneumococcal conjugate vaccine is proposed for further production and preclinical and clinical trials. A new Russian pneumococcal conjugate vaccine will ensure vaccination of all population groups within the National Immunisation Schedule of the Russian Federation.

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Etiological role and molecular-genetic features of <i>Streptococcus pneumoniae</i> in children’s infectious diseases

Cited by 2 publications

References 7 publications

Preventive Efficacy of Pneumococcal Conjugated Vaccine (Population Aspects)

Preventive Efficacy of Pneumococcal Conjugated Vaccine (Population Aspects)

Analysis of pneumococcal serotypes distribution to determine a model composition for a Russian pneumococcal conjugate vaccine

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