Etiologies of Chronic Cough in Pediatric Cohorts

Panel, Chest Expert Cough

doi:10.1016/j.chest.2017.06.006

Cited by 68 publications

(79 citation statements)

References 55 publications

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“…Some speculations need to be addressed. A low rate of UACS was reported only when ENT evaluation and allergy skin tests were not performed in the diagnostic workup (7,47). Both investigations were included in studies reporting a high frequency of UACS (28, 29), confirming at least an association between allergy and upper airway involvement (48).…”

Section: Discussionmentioning

confidence: 99%

Wet Cough and Nasal Symptoms in Children: Can We Do Better?

Benedictis

Carloni²,

Comberiati

et al. 2019

Front. Pediatr.

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The causes of chronic cough in children are mainly dependent on the setting and age of the child. Protracted bacterial bronchitis is a frequent cause of morbidity in childhood, and antibiotic treatment is beneficial. Prompt recognition and early treatment is important both to prevent inappropriate use of asthma medications and also progression to bronchiectasis, but the diagnosis should not be made uncritically, because chronic wet cough is not necessarily due to lower airway disease. Upper Airway Cough Syndrome (UACS) is considered by some to cause chronic cough in childhood. Underlying UACS are many common conditions, including allergic rhinitis, adenoiditis and rhinosinusitis. Diagnosis relies on a combination of clinical criteria that are relatively sensitive but non-specific. The role of nasal endoscopy in children with chronic cough and signs suggesting UACS is unclear. Nasal saline solution irrigation is commonly used in UACS, but most studies have methodological biases, and efficacy data are scanty. Randomized controlled trials are urgently required. However, if saline washes, rather than oral antibiotics, can effectively treat some children with wet cough associated with upper airway conditions, antibiotic resistance could potentially be reduced. There is a need to further study wet cough and not to assume it to be equivalent to lower airway infection in all children.

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Section: Discussionmentioning

confidence: 99%

Wet Cough and Nasal Symptoms in Children: Can We Do Better?

Benedictis

Carloni²,

Comberiati

et al. 2019

Front. Pediatr.

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“…Contrary to R5 and R20, however, R5-20, X5, and AX were not associated with persistent cough. Although persistent troublesome cough is associated with later asthma, 27 the symptom can result from a wide variety of causes 28 and is thus less specific for airway obstruction than recurrent wheezing episodes. 29 Therefore, it is possible that this patient subgroup included children with symptoms that resulted from other causes than asthma, blunting the discriminatory power of the investigated indexes.…”

Section: Discussionmentioning

confidence: 99%

“…It is, however, possible that not all the symptomatic children present with chronic asthma, especially those with isolated cough. Because of challenges in the differential diagnostics of persistent cough, 28 the discriminatory analyses were performed for both symptomatic subgroups separately, and the ROC analyses only included children with recurrent wheezing. Third, the control group was relatively small and could not be completely matched with symptomatic children with regard to age and sex.…”

Section: Discussionmentioning

confidence: 99%

Small airway function in children with mild to moderate asthmatic symptoms

Knihtilä

Kotaniemi‐Syrjänen

Pelkonen

et al. 2018

Annals of Allergy, Asthma & Immunology

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“…Cough can be seen as being caused by inflammation, increased secretions, or extra-respiratory causes (9). In general, chronic cough symptoms may be considered to be from one or a combination of any of the following (Table 1): upper airway; lower airway; GI tract, or other organ systems (cardiac, immune, or rheumatologic conditions) (8, 11, 12). Due to the complexity of the patients seen, the failure of treatment, and the broad differential diagnosis, a thorough history and physical exam is crucial to narrow down the possible etiologies and to decide whether further evaluation is needed.…”

Section: Pediatric Pulmonologist Perspectivementioning

confidence: 99%

“…In the last few years, the ACCP has produced two systematic reviews regarding pediatric chronic cough. The first described the etiologies of chronic cough in children and how it differs from that in adults (8). The second focused on determining the most effective treatments for chronic wet cough (10).…”

Section: Introductionmentioning

confidence: 99%

Aerodigestive Approach to Chronic Cough in Children

Naime

Batra

Fiorillo

et al. 2018

Curr Treat Options Peds

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Purpose of review: Chronic cough is the most common presenting complaint in a pediatric aerodigestive clinic. The etiology of chronic cough is varied and often includes more than one organ system. This review aims to summarize the current literature for a multidisciplinary approach when evaluating a child with chronic cough. Recent findings: There is very little medical literature focused on a multidisciplinary approach to chronic cough. In the limited data available, multidisciplinary clinics have been shown to be more cost-efficient for the families of children with complex medical problems, and also increase the likelihood of successfully obtaining a diagnosis. Summary: There is no consensus in the literature on how to work-up a child with chronic cough presenting to an aerodigestive clinic. Current studies from these clinics have shown improved outcomes related to cost-effectiveness and identifying definitive diagnoses. Future studies evaluating clinical outcomes are necessary to help delineate the utility of testing routinely performed, and to demonstrate the impact of interventions from each specialty on quality of life and specific functional outcome measures.

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Etiologies of Chronic Cough in Pediatric Cohorts

Cited by 68 publications

References 55 publications

Wet Cough and Nasal Symptoms in Children: Can We Do Better?

Wet Cough and Nasal Symptoms in Children: Can We Do Better?

Small airway function in children with mild to moderate asthmatic symptoms

Aerodigestive Approach to Chronic Cough in Children

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