Etiology and Clinical Outcomes of Neonatal and Pediatric Sepsis

Pawar, Atmaram; Raut, Asawari; Kalrao, Vijay; Jacob, John; Godha, Isha; Thomas, Ritty

doi:10.5812/pedinfect.33602

Cited by 11 publications

(9 citation statements)

References 12 publications

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“…The odds of neonatal death were two times more likely observed among neonates who had an infection (sepsis, pneumonia, meningitis) aside from no infection. This finding is in agreement with the previous studies conducted in Ethiopia and Uganda [14,15,17], as infection (sepsis) is complicated to septic shock and multiple organ dysfunction, in which both are the most common causes of death in the neonatal period [34].…”

Section: Discussionsupporting

confidence: 93%

Determinants of neonatal mortality at neonatal intensive care unit in Northeast Ethiopia: unmatched case-control study

Alemu¹,

Belay²,

Gobeza³

et al. 2020

Trop Med Health

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Background: Globally, in 2016, about 38% and 3% of all neonatal death were recorded in sub-Saharan Africa and Ethiopia, respectively. In the same year, 47 neonates out of 1000 live births were not surviving in the first 28 days of age in the Amhara region, Ethiopia. Despite the highest burden of neonatal death in the region, specific or the proximate determinants of neonatal death in the neonatal intensive care unit were not well identified.

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Section: Discussionsupporting

confidence: 93%

Determinants of neonatal mortality at neonatal intensive care unit in Northeast Ethiopia: unmatched case-control study

Alemu¹,

Belay²,

Gobeza³

et al. 2020

Trop Med Health

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“…The median length of stay of survivors was eight days, while two days in nonsurvivors. It indicated that severe condition had a greater probability of mortality [17]. The study by Pawar (2016) demonstrated that significant relationship between mortality and severity of sepsis.…”

Section: Discussionmentioning

confidence: 97%

CD64 Index as a Predictor of Outcome for Children with Systemic Inflammatory Response Syndrome (SIRS)

Yetti¹,

Herlina²,

Mayetti³

et al. 2019

Proceedings of the Proceedings of the 1st EAI International Conference on Medical and Health Research, ICoMHER November 13-14th

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Sepsis is one of the major causes of mortality and morbidity in children. The study aimed to assess the prognostic value and difference of Neutrophil CD64 index regarding sepsis outcome. Methods of this study were a prospective observational study in 62 children with Systemic Inflammatory Response Syndrome (SIRS) were conducted in ER and Pediatric Ward Dr. M. Djamil Hospital, Padang. We collected blood samples to measure Neutrophil CD64 index and blood cultures were drawn to confirm infection. Patients were observed clinically until discharge from the hospital. Based on the clinical course and laboratory test results, patients were categorized as having unproven sepsis, sepsis, septic shock, and nonsurvivor. The average Neutrophil CD64 index were 1.13±0.32; 1.71±0.23; 2.29±0.71; 2.86±1.10 for unproven sepsis, sepsis, septic shock, and nonsurvivors, respectively. The area under the curve (AUC) for hospital mortality was 0.863. At a cutoff level of 1.705 sensitivity was 71.4% and specificity was 72.9%. Patients with CD64 index level higher than 1.705 had 6.7-fold higher probability of dying. The odd ratio is 6.7 (95% CI 1.79-25.27). Neutrophil CD64 was significantly elevated as a severe outcome of sepsis. This result indicates that neutrophil CD64 may be used as a biomarker for predicting mortality.

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“…In this study, first nanoparticles were prepared and then their effect on different pathogens (5,10,50, and 100 ppm) was investigated for optical density (OD) test, and, (1.5, 1.75, 2.5, 2.75, and 4.5) mg was examined to count colony forming units test (CFU).…”

Section: Methodsmentioning

confidence: 99%

“…The lower part of the respiratory system 8 Blood flow 14 Remain parts Antibiotic-resistant organisms are one of the reasons for the increase in nosocomial infections, so controlling these infections should not be based solely on diagnosis, but on determining the type of pathogen responsible and its sensitivity to antibiotics, and different ones are also important [10].…”

Section: Urinary Tract 18mentioning

confidence: 99%

Bactericidal Properties of Copper-Tin Nanoparticles on Escherichia coli in a Liquid Environment

Rezayat

Yazdi

Noghani

et al. 2020

Plasma

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In this research, copper-tin alloy nanoparticles were made by a mechanical alloying method and were examined by two well-known and common bactericidal tests, optical density, and colony-forming units count in terms of bactericidal properties. To confirm the results, two different percentages were used as Sn-50Cu and Sn-83Cu, and standard amounts of these alloys were added to the Escherichia coli bacterial culture medium. The results of optical density show that with the addition of more values to the culture medium for bacteria, witnessing the destruction of bacteria, and also the results of colony counting tests can be seen that the number of colonies has decreased over time, even close to zero, which means the environment is free of bacteria. These standard values were different for both alloys; for the Sn-50Cu alloy, the maximum value was 4.5 mg, and for the Sn-83Cu alloy, it was 2.75 mg, which did not make any difference with the addition of these nanoparticles to the bacterial culture medium.

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Etiology and Clinical Outcomes of Neonatal and Pediatric Sepsis

Abstract: Background: Sepsis can be defined as the body's response to an infection. Sepsis in children remains a significant cause of morbidity and mortality worldwide.

Cited by 11 publications

References 12 publications

Determinants of neonatal mortality at neonatal intensive care unit in Northeast Ethiopia: unmatched case-control study

Determinants of neonatal mortality at neonatal intensive care unit in Northeast Ethiopia: unmatched case-control study

CD64 Index as a Predictor of Outcome for Children with Systemic Inflammatory Response Syndrome (SIRS)

Bactericidal Properties of Copper-Tin Nanoparticles on Escherichia coli in a Liquid Environment

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