Etiology and clinical profile of neonates with pathological unconjugated hyperbilirubinemia with special reference to Rhesus (Rh) D, C, and E incompatibilities: A tertiary care center experience

Singh, Sharad; Singh, SK; Kumar, Madhu; Tripathi, Shalini; Bhriguvanshi, Arpita; Chandra, Tulika; Kumar, Ashutosh

doi:10.1016/j.cegh.2016.03.006

Cited by 5 publications

(6 citation statements)

References 27 publications

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“…Various studies observed idiopathic cause as an etiology in 15.5% -25.4% cases. 17,18 In our study we identified ABO incompatibility (8.24%) and Rh incompatibility (4.12%) as a risk factors for neonatal jaundice. Neonatal jaundice in babies with ABO incompatibility and Rh incompatibility is mainly due to hemolysis.…”

Section: Discussionmentioning

confidence: 62%

Untitled

2019

MIJOPED

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Background: Neonatal hyperbilirubinemia It may be physiological or pathological. Neonatal hyperbilirubinemia is a common condition requiring inpatient treatment and monitoring, and many times requires readmission to hospital. Estimated incidence of jaundice in neonates is 60% to 84% of late term and term infants. Present study was undertaken to study clinical profile of neonates with jaundice at our tertiary care center. Material and Methods: This prospective, observational study was conducted in neonates with jaundice admitted in NICU or neonatology ward during study period, with serum bilirubin more than 10 mg/dL. Results: During study period 340 newborns were considered for present study. 159 newborns (47 %) developed jaundice after 72 hours of birth. Only 14 % developed jaundice within 24 hours of birth. 56 % babies were male as compared to 44% female babies. Babies delivered at more than 37 weeks gestational age (70 %) were most common, while only 7% babies were delivered between 28-32 weeks gestational age. 2500-4000 gm birthweight babies were 66 %, while 28% babies had birthweight less than 2500 gm. Incidence of neonatal jaundice was 58%, 31% and 10% in vaginal delivery, caesarean section, instrumental delivery respectively. Physiological jaundice (36.17%), prematurity (13.53%), breast feeding (12.65%), idiopathic (12.35 %), were most common causes noted in our study. Conclusion: Male gender, 2500-4000 gm birthweight, vaginal delivery, physiological jaundice, prematurity were common causes associated with neonatal jaundice in our study. Parental counselling and monitoring of baby is most important in management of neonatal jaundice.

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Section: Discussionmentioning

confidence: 62%

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2019

MIJOPED

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“…Various studies observed idiopathic cause as an aetiology in 15.5-25.4% cases. 19,20 In our study we identified Abo incompatibility (06.19%) and Rh incompatibility (10.91%) as a risk factor for neonatal jaundice. Neonatal jaundice in babies with ABO incompatibility and Rh incompatibility is mainly due to haemolysis.…”

Section: Discussionmentioning

confidence: 63%

Study of aetiological factors and clinical profiles of neonatal jaundice in the special newborn care unit of tertiary care hospital of Government Medical College, Rajouri, Jammu and Kashmir union territory: a hospital-based study

Iqbal

Sharma

Naaz³

2023

Int J Res Med Sci

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Background: Neonatal hyperbilirubinemia may be physiological or pathological. Neonatal hyperbilirubinemia is a common condition requiring inpatient treatment and monitoring and many time requires readmission to hospital. Estimated incidence of jaundice in neonates is 60% to 84% of late term and term infants. Present study was undertaken to study clinical profile of neonates with jaundice at our tertiary care centre. Methods: This prospective observational study was conducted in neonates with jaundice admitted in SNCU ward during study period with serum bilirubin more than 10 ml/dl. Results: During study period 339 neonates were considered for presented study. 192 newborns (56.63%) developed jaundice after 72hrs. of birth. Only 28.90% newborns developed jaundice within 24 hrs. Of birth. 61.65% babies were male as compared to 38.34% female babies. Jaundice was most commonly noted in babies delivered at more than 34 weeks gestational age (60.17%), while only 10.02% babies were delivered between 28-32 weeks gestational age. 2500- 4000 gm birth weight babies were 60.14% while only 39.82% babies had weight less than 2500 gms. Incidence of neonatal jaundice was 60.06%, 30.38%, 08.55% in vaginal, caesarean section and instrumental delivery respectively. Physiological jaundice (30.67%), prematurity (25.30%), Rh incompatibility (10.91%), breast feeding/jaundice (10%), ABo incompatibility (6.19) and idiopathic (5.01%) were most common causes noted in our study. Conclusions: Male gender, 2500-4000 gm birth weight, vaginal delivery, physiological delivery, prematurity were common causes associated neonatal jaundice in our study. Parent counselling and monitoring of baby is most important in management of neonatal jaundice.

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“…However, the rate of minor blood group incompatibility other than Rh (D) antigen such as Kell, c, C, E, e, duffy is increasing (14). Subgroup incompatibility should be considered in the presence of severe hemolysis with indirect hyperbilirubinemia, and/or in newborns with DCT positive and profound anemia (15). Newborns with subgroup blood group incompatibility may present with a clinical spectrum ranging from asymptomatic to severe hydrops fetalis (16).…”

Section: Discussionmentioning

confidence: 99%

İndirekt Hiperbilirubinemide Exchange Transfüzyon Uygulanması: Tek Merkez Deneyimi

Deger

İLTER

2022

Harran Üniversitesi Tıp Fakültesi Dergisi

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Objective: Hyperbilirubinemia is a common clinical condition in newborn infants, and bilirubin encephalopathy remains an important health problem today. Decreased bilirubin anxiety and inadequate etiological evaluations lead to serious problems such as kernicterus. In this study, the development of bilirubin encephalopathy and its etiological causes were evaluated in patients who received exchange transfusion due to indirect hyperbilirubinemia for a period of one year. Methods: Newborns admitted to the Neonatology clinic between September 2020 and August 2021 due to indirect hyperbilirubinemia and undergoing exchange transfusion were analyzed retrospectively. Demographic data, laboratory parameters, and incidence of complications related to exchange transfusion were investigated. Results: A total of 62 infants, 61.3%(38) boys and 38.7%(24) girls, were included in the study. 53.2%(33) of the patients were delivered by cesarean section. Mean gestational age was 38(36-41) weeks and mean birth weight was 3063±478 grams. The median age at presentation was found to be 5 (1-22) days. In the etiological evaluation of the cases, 27.4%(44) Rh incompatibility, 50%(31) ABO incompatibility, 46.8%(29) Subgroup incompatibility were observed. More than one discrepancy was detected in 33.8%(21) of the patients. Glucose 6 phosphate dehydrogenase enzyme deficiency was detected in 21% (13) of the cases. No etiological cause was found in 4.8%(3) of the patients. Conclusion: Indirect hyperbilirubinemia and related bilirubin encephalopathy still remain a serious problem and therefore exchange transfusion may be required. In order to reduce serious morbidity and even mortality due to indirect hyperbilirubinemia, bilirubin monitoring should be done closely and risky babies should be determined in advance with etiological evaluations.

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Etiology and clinical profile of neonates with pathological unconjugated hyperbilirubinemia with special reference to Rhesus (Rh) D, C, and E incompatibilities: A tertiary care center experience

Abstract: c l i n i c a l e p i d e m i o l o g y a n d g l o b a l h e a l t h 4

Cited by 5 publications

References 27 publications

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Study of aetiological factors and clinical profiles of neonatal jaundice in the special newborn care unit of tertiary care hospital of Government Medical College, Rajouri, Jammu and Kashmir union territory: a hospital-based study

İndirekt Hiperbilirubinemide Exchange Transfüzyon Uygulanması: Tek Merkez Deneyimi

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