Etiology and epidemiology of end-stage renal disease in Dutch children 1987–2001

Miklovicova, Daniela; Cornelissen, Elisabeth A.M.; Cransberg, Karlien; Groothoff, Jaap W.; Dedik, Ladislav; Schröder, Cornelis H.

doi:10.1007/s00467-005-1896-7

Cited by 32 publications

(33 citation statements)

References 12 publications

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“…The distribution of diagnoses has also been affected over the years by the transplantation of infants, most of whom have structural abnormalities, whereas glomerulopathies and other diagnoses present later. The incidence of structural abnormalities of 44% in our study is similar to that reported for the Dutch cohort [24]. There has been a parallel increase in the proportion diagnosed antenatally which has now reached 50% [25].…”

Section: Discussionsupporting

confidence: 78%

Long-Term Outcome of Paediatric Renal Transplantation: Follow-Up of 300 Children from 1973 to 2000

Rees¹,

Shroff²,

Hutchinson³

et al. 2006

Nephron Clin Pract

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Background/Aim: To report our experience of paediatric renal transplantation at Great Ormond Street and Royal Free Hospitals since the inception of the programme. Methods: Retrospective review of the patient and transplant survival and influencing factors in the 300 children transplanted between 1973 and 2000. Results: 300 children had received a total of 354 transplants; 56 were living-related donations. The median age at transplantation was 10.3 (range 1.4–17.9) years. Forty-four percent had congenital structural abnormalities of the urinary tract. Forty-six children required a second and 8 a third transplant before transfer to an adult unit. The overall patient survival at 5, 10, and 20 years was 97, 94, and 72%, respectively. In the overall cohort, the donor type (deceased donor or living-related donor) did not affect mortality, nor did age at transplantation, but those transplanted before 5 years of age had a significantly shorter post-transplant survival time (p < 0.0001). Transplant survival (first transplant) for deceased and living-related donors was 66 and 87% at 5 years (p < 0.01), 51 and 54% at 10 years, and 36% at 20 years (deceased-donor transplants only). Although the overall transplant survival was inferior in children transplanted before 2 years of age (p < 0.03), in the most recent cohort (1990–2000), age did not affect the outcome. On multiple regression analysis, the only predictor of transplant survival was the era of transplantation (p < 0.001). The median final height was within the normal range for males and females; 7 patients received growth hormone after transplantation. Conclusions: The outlook for successful transplantation is improving, and in the last decade was unaffected by age at transplantation. The survival of living-related donor transplants is superior to deceased-donor transplants for the first 5 years. From the above data, we can predict that a 10-year-old child receiving a renal transplant in 2000 and on ciclosporin-based immunosuppression can expect a transplant half-life of 13.1 years from a living-related donor and one of 10.8 years from a deceased-donor transplant.

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Section: Discussionsupporting

confidence: 78%

Long-Term Outcome of Paediatric Renal Transplantation: Follow-Up of 300 Children from 1973 to 2000

Rees¹,

Shroff²,

Hutchinson³

et al. 2006

Nephron Clin Pract

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“…In the same period, 36/143 (25%) patients were transplanted, among whom 8/36 (22%) had a preemptive transplantation (one with a living related donor allograft). The median age at first transplantation was 5 years (interquartile range [3][4][5][6][7][8][9][10][11]. Among all transplanted children, 31/36 (86%) received a graft from cadaveric origin and 5/36 (14%) received a graft from a living-related donor.…”

Section: Renal Replacement Therapymentioning

confidence: 99%

Clinical characteristics and outcomes of children with stage 3–5 chronic kidney disease

et al. 2010

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The aim of this study was to report on the clinical characteristics and outcomes of Belgian children with chronic kidney disease (CKD). Between 2001 and 2005, we followed 143 new successive patients younger than 20 years of age with a glomerular filtration rate of <60 ml/min/1.73 m(2) prospectively in a Belgian department of pediatric nephrology. The incidence of diagnosed CKD was 11.9 per million child population (pmcp), and the incidence of renal replacement therapy was 6.2 pmcp. There were 67% patients in CKD stage 3, 19% in CKD stage 4 and 14% in CKD stage 5. Patients with congenital anomalies of the kidney and urinary tract (CAKUTs), hereditary diseases and glomerular diseases were diagnosed at a median age of 1, 2 and 10 years, respectively. CAKUTs were the main causes of CKD, accounting for 59% of all cases. After 3, 4 and 5 years of follow-up, 27, 31 and 38% of patients treated conservatively, respectively, reached end-stage renal failure (ESRF). The progression rate to ESRF was eightfold higher in patients with CKD stage 4 than in those with CKD stage 3. Among our patient group, hereditary diseases progressed more rapidly to ESRF than CAKUTs. Transplantation was performed preemptively in 22% of these children. Infections and cardiovascular diseases were the main causes of death.

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“…Data from early human and animal studies suggested that UTI in the presence of VUR may cause renal scarring [3]. Various studies subsequently reported that 7-17 % of end-stage renal disease (ESRD) is associated with VUR [4][5][6], attributable chiefly to renal dysplasia rather than postnatal scarring. Based on the assumption that long-term antibiotic prophylaxis or surgical reimplantation would prevent UTI and subsequent renal scarring, these interventions became the standard clinical practice for the treatment of VUR.…”

Section: Introductionmentioning

confidence: 99%

Antibiotic prophylaxis in the management of vesicoureteric reflux: a randomized double-blind placebo-controlled trial

Hari

Sinha

et al. 2014

Pediatr Nephrol

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Etiology and epidemiology of end-stage renal disease in Dutch children 1987–2001

Cited by 32 publications

References 12 publications

Long-Term Outcome of Paediatric Renal Transplantation: Follow-Up of 300 Children from 1973 to 2000

Long-Term Outcome of Paediatric Renal Transplantation: Follow-Up of 300 Children from 1973 to 2000

Clinical characteristics and outcomes of children with stage 3–5 chronic kidney disease

Antibiotic prophylaxis in the management of vesicoureteric reflux: a randomized double-blind placebo-controlled trial

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