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“…3,4 The usefulness of the hypoxic rat model is controversial. 5,6 In the present study, we investigate the effect of subanaesthetic doses of thiopentone and fentanyl on liver function in rats when these drugs are given either as a single dose or as repeated doses. The experimental conditions we applied were similar to those patients undergoing intensive care in whom narcotics and anaesthetics are given as a continuous infusion or as repeated injections.…”
mentioning
confidence: 99%
“…3,4 The usefulness of the hypoxic rat model is controversial. 5,6 In the present study, we investigate the effect of subanaesthetic doses of thiopentone and fentanyl on liver function in rats when these drugs are given either as a single dose or as repeated doses. The experimental conditions we applied were similar to those patients undergoing intensive care in whom narcotics and anaesthetics are given as a continuous infusion or as repeated injections.…”
mentioning
confidence: 99%
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