Etiology, pathogenesis, and pathophysiology of ankylosing spondylitis

Baeten, D

doi:10.1016/b978-0-323-06551-1.00113-5

Cited by 1 publication

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“…Spondylarthropathies (SpA) comprise a group of inflammatory disorders, which are similar to each other in terms of clinical features and genetic susceptibility [ 7 ]. Ankylosing spondylitis (AS) is the prototype of these disorders and present particularly with inflammatory back pain (IBP) and radiologically-detected sacroiliitis [ 8 ]. The prevalence of SS in patients with the diagnosis of SpA has been reported to be higher compared to control groups and population surveys in previous studies [ 9 - 14 ].…”

Section: Introductionmentioning

confidence: 99%

Prevalence of inflammatory back pain and radiologic sacroiliitis is increased in patients with primary Sjögren’s syndrome

Eren¹,

Can²,

Alıbaz-Öner³

et al. 2018

Pan Afr Med J

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IntroductionThe prevalence of Sjögren's syndrome (SS) in patients with the diagnosis of SpA has been reported to be higher than normal population. Yet, the vice-versa is unclear. In this study, we aimed to investigate the prevalence of IBP, radiologic sacroiliitis and SpA in patients with primary SS.Methods85 patients followed at the rheumatology clinics of the Marmara and Kocaeli Universities with the diagnosis of primary SS between November 2011 and August 2012 were included in this study. The control group consisted of 100 age-and gender-matched patients. Inflammatory back pain and axial SpA were diagnosed according to the assessment of spondylo arthritis International Society (ASAS) criteria.Results83 patients were (97%) female and 2 (3%) were male. Mean age of the patients was 49.1 (±11) years. Mean disease duration was 7.3 (±4) years. The patient and control groups were comparable in terms of age and gender (p > 0.05). Inflammatory back pain was observed in 21 (24.7%) of 85 primary SS patients and in 4 (4%) of 100 control subjects (p < 0.001), radiographic sacroiliitis was demonstrated in 9 (10.5%) of primary SS patients and 2 (2%) of the control subjects (p = 0.025). Remaining SpA findings were not encountered in either group.Conclusioninflammatory back pain and radiologic sacroiliitis is increased in patients with primary SS. Whether IBP, SI joint inflammation and radiologic sacroiliitis is due to the co-existence of SpA and primary SS or IBP is an underdiagnosed clinical feature of SS deserves further studies of large patient numbers.

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Section: Introductionmentioning

confidence: 99%