Etiopathogenesis of Alopecia Areata

Bhat, Yasmeen Jabeen; Sajad, Peerzada; Hassan, Iffat

doi:10.4172/2167-0951.1000123

Cited by 5 publications

(5 citation statements)

References 36 publications

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“…AA is a common nonscarring type of alopecia, which has different clinical presentations, classified according to the hair loss pattern or extent [37]. In some cases, AA is associated with other autoimmune diseases such as vitiligo, atopic dermatitis, diabetes, hypothyroidism, and pernicious anemia [39][40][41].…”

Section: Alopecia Areatamentioning

confidence: 99%

Platelet-Rich Plasma and its Use for Cicatricial and Non-Cicatricial Alopecias: A Narrative Review

Alves

Grimalt

2020

Dermatol Ther (Heidelb)

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The concept and description of platelet-rich plasma (PRP) started in the field of hematology and is being extensively used in other fields of medicine. Interest in the application of PRP has been increasing in dermatology, such as in tissue regeneration, wound healing, scar revision, skin-rejuvenating effects, and alopecia. PRP is an autologous blood product containing high concentrations of platelets in a small volume of plasma. Different preparations of PRP may lead to different volumes of PRP, platelet concentration, and presence or absence of leukocytes. PRP is being used as a new therapy for some types of non-cicatricial alopecia such as androgenetic alopecia (AGA) and alopecia areata (AA) and, recently, new insights refer to the possibility of action in the field of cicatricial alopecia, like lichen planopillaris (LPP) and frontal fibrosing alopecia (FFA). This article aims to identify the major indications for the application of PRP in the field of hair disorders, including non-cicatricial and cicatricial alopecia.

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Section: Alopecia Areatamentioning

confidence: 99%

Platelet-Rich Plasma and its Use for Cicatricial and Non-Cicatricial Alopecias: A Narrative Review

Alves

Grimalt

2020

Dermatol Ther (Heidelb)

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“…It is a common disease that affects 1%‐2% of population, with increased incidence between the second and fourth decades of life. It is frequently a common association with other autoimmune diseases such as vitiligo, atopic dermatitis, diabetes, hypothyroidism, and pernicious anemia . Chronic and recurrent cases of AA have been associated with emotional and psychological stress .…”

Section: Introductionmentioning

confidence: 99%

Evaluation of platelet‐rich plasma vs intralesional steroid in treatment of alopecia areata

Albalat

Ebrahim

2019

J of Cosmetic Dermatology

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Summary Background Alopecia areata (AA) is nonscarring patchy area of hair loss. Platelets rich plasma (PRP) promotes development of new hair follicles. Dermoscopy is a diagnostic tool that helps in evaluation of skin microstructures which are not visible to naked eye. Aim To evaluate safety and efficacy of (PRP) vs intralesional corticosteroid (ILCs) in treatment of AA. Patients and methods This study was conducted on 80 patients of both sexes who had AA. Patients were classified into Group I treated by ILCs and group II treated by (PRP). Results were assessed by dermoscopic evaluation and by hair re‐growth score (RGS) at (baseline), 2, 4, 6, 8, and 12 weeks. Patients were followed up for 6 months. Results There was greater hair re‐growth after treatment in both groups. In group I, (26) patients (65%) showed improvement >70% compared to 29 patients (72.5%) in group II. There was significant re‐growth of pigmented hair and decrease in dystrophic hair (P < 0.001) by dermoscopic evaluation in both groups. The difference between both groups was insignificant (P = 0.57). At follow‐up, two (5%) patients in group II had relapse compared to 10 (25%) patients in group I. Conclusion Platelets rich plasma is safe and promising therapeutic option in AA.

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“…4 However, in a review study by Bhat et al, it is reported to account for 2-3% of the new dermatology cases in UK and USA, 3.8% in China, and 0.7% in India. 5 Both males and females are equally likely to be affected, but some studies reported male preponderance.…”

Section: Introductionmentioning

confidence: 99%

Dermoscopic evaluation of therapeutic response to intralesional triamcinolone acetonide in the treatment of Alopecia areata

et al. 2017

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Background: Alopecia areata is a common auto-immune condition, characterized by circumscribed, patches of hair loss usually of the scalp. There are various treatment modalities available but no treatment is fully curative or preventive. Also, alopecia areata can have devastating effects on the patient’s quality of life and self-esteem. The aim of this study was to determine dermoscopy findings of alopecia areata that could be used as a clinical indicator of disease and also to evaluate the efficacy of intralesional injection Triamcinolone acetonide in the treatment of alopecia areata.Methods: Seventy patients with alopecia areata, aged between 11 and 56 years were injected with intralesional triamcinolone acetonide at a 4 weeks interval. Treatment response was evaluated using re-growth scale approach. Dermlite DL3 dermoscope was used to assess disease activity, response to treatment and side effects. Using Wilcoxon signed rank test, changes were assessed in the severity of the disease during follow-ups.Results: Baseline mean percentage area of scalp involved was 23.21±10.70. All the patients had black dots, 98.6% had yellow dots, 27.1% had broken hair, 74.3% had tapering hair and only 71.4% had vellus hair. At baseline, 15 (21.4%) patients had Alopecia Grading Score (AGS) 1, 29 (41.4%) had score 2 and 26 (37.1%) had a score of 3. Injection Triamcinolone acetonide (5 mg/ml) was injected at 1 cm intervals with 0.1 ml on each site and the procedure was repeated every 4 weeks for a maximum period of 24 weeks. From baseline level to the last follow up, proportion of patients with black dots reduced from 100% to 4.3%, yellow dots from 98.6% to 0%, broken hair from 17% to 0% and tapering hair from 74.3% to 0%. Vellus hair increased from 71.4% to 100%. Overall success rate in terms of achievement of re-growth Ssore 4 at last follow up was 60%.Conclusions: Dermoscopic characteristics, such as black dots, yellow dots, broken hair, tapering hair and clustered short vellus hair are primary indicators of alopecia areata.

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Etiopathogenesis of Alopecia Areata

Cited by 5 publications

References 36 publications

Platelet-Rich Plasma and its Use for Cicatricial and Non-Cicatricial Alopecias: A Narrative Review

Platelet-Rich Plasma and its Use for Cicatricial and Non-Cicatricial Alopecias: A Narrative Review

Evaluation of platelet‐rich plasma vs intralesional steroid in treatment of alopecia areata

Dermoscopic evaluation of therapeutic response to intralesional triamcinolone acetonide in the treatment of Alopecia areata

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