Etiopathogenesis of presenile cataracts in Central Kerala: A cross-sectional observational study

Jyothi, R; Sathyan, Sanitha

doi:10.4103/kjo.kjo_102_17

Cited by 5 publications

(4 citation statements)

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“…The authors attributed this effect to additional factors involving patients undergoing Age-related cataracts comprised the vast majority of cataracts, but the risk factors were different from early-onset cataracts. Some known risk factors for early-onset cataracts included trauma, ultraviolet-B exposure, steroid use, diabetes mellitus and myotonic dystrophy, but not CKD (24)(25)(26). In our longitudinal cohort, we divided participants by age (<60 years old and ≧60 years old) and found that the relationship between CKD and cataracts was not statistically significant in those <60 years old, supporting the previous results.…”

Section: Discussionmentioning

confidence: 99%

Chronic kidney disease and its association with cataracts–A cross-sectional and longitudinal study

Huang

Lee

Chang

et al. 2022

Front. Public Health

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IntroductionWe aim to explore the association between chronic kidney disease (CKD) and cataracts.MethodsA total of 121,380 participants with adequate information collected from 29 community-based recruitment centers since 2008 were analyzed. The association between CKD and self-reported diagnosed cataracts was examined in a cross-sectional cohort and was validated in a longitudinal cohort of 25,263 participants without cataracts at baseline.Results and discussionOf all participants, cataracts occurred in 503/1,947 (26%) and 10,464/119,433 (9%) subjects in the CKD and non-CKD groups, respectively. Multivariate logistic regression showed that CKD was significantly associated with a higher prevalence of self-reported diagnosed cataracts. In the validation cohort, a higher incidence of cataracts was also noted in the CKD group (65/317, 21%) compared to the non-CKD group (1,964/24,252, 8%) during a mean 47-month follow-up. After adjusting for confounders, subjects with CKD had a 1.498-fold higher risk of incident cataracts than those without CKD (95% confidence interval = 1.114 to 2.013, p value = 0.007). We found that CKD was associated with a higher prevalence of cataracts as well as incident cataracts, which suggests CKD patients and their primary physicians should be aware of this disease and can provide a clue for further exploration of the possible mechanisms and treatments.

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Section: Discussionmentioning

confidence: 99%

Chronic kidney disease and its association with cataracts–A cross-sectional and longitudinal study

Huang

Lee

Chang

et al. 2022

Front. Public Health

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“…Several previous studies have been performed to explore the risk factors for EOC. Some known risk factors include sunlight exposure, trauma, steroid use, and diabetes mellitus (12)(13)(14)(15). Despite the widely reported associations between smoking and cataracts, it is unclear from the existing literature if this is true for EOC as well.…”

Section: Discussionmentioning

confidence: 99%

Findings from the 45 and Up Study: smoking is not associated with the risk of early-onset cataract

et al. 2021

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Background: To determine if tobacco smoking is a risk factor for early-onset cataracts.Methods: This was a prospective population-based cohort study. A total of 70,886 participants aged 45-55 years in the 45 and Up Study were included in our analysis. Early-onset cataracts (EOC) were defined as cataract surgeries performed before 65 years old, based on participant data linked to the Medicare Benefits Schedule (MBS). Smoking habits were assessed at baseline, based on a self-administered questionnaire. A Cox proportional hazards model was used to evaluate the association between tobacco smoking and the risk of early-onset cataracts over the follow-up period.Results: At baseline recruitment, 59.9% of study participants never smoked, 30.5% were former smokers, and 9.6% were current smokers. A total of 1,713 participants underwent cataract surgery over a mean followup of 625,042 person-years, with an incidence of 2.74 cases per 1,000 person-years. For current smokers, patients with EOC had longer smoking durations (P=0.019). For former smokers, patients with EOC had higher smoking intensities (P=0.001), were older at smoking commencement (P=0.011), and longer times since quitting (P=0.04). The risk of EOC was not found to be significantly different between current smokers or former smokers, compared to those who had never smoked. Both stratification and sensitivity analyses by gender, surgery year, alcohol intake, physical activity, and income yielded similar results.Conclusions: Smoking has neither a beneficial nor harmful effect on the long-term incidence of EOC.

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“…Regarding EOC, little is known about its etiology, risk factors, and mechanism. Possible risk factors reported in the literature include steroid use, sunlight exposure, diabetes, and trauma (20)(21)(22)(23). No previous studies explored the association between BMI and EOC, and the present study identified there were no significant associations between them.…”

Section: Discussionmentioning

confidence: 99%

Body mass index is not associated with early onset cataract in the 45 and Up cohort study

Zhang¹,

Wang²,

Yang³

et al. 2021

Ann Transl Med

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Etiopathogenesis of presenile cataracts in Central Kerala: A cross-sectional observational study

Cited by 5 publications

References 0 publications

Chronic kidney disease and its association with cataracts–A cross-sectional and longitudinal study

Chronic kidney disease and its association with cataracts–A cross-sectional and longitudinal study

Findings from the 45 and Up Study: smoking is not associated with the risk of early-onset cataract

Body mass index is not associated with early onset cataract in the 45 and Up cohort study

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