Etomidate plus propofol versus propofol alone for sedation during gastroscopy: a randomized prospective clinical trial

Zhou, Xiang; Li, Bixi; Chen, Limin; Tao, Jun; Zhang, Sui; Ji, Meng; Wu, Mingchun; Chen, Min; Zhang, Yanhui; Guo-shen, Gan; Song, Xiaofeng

doi:10.1007/s00464-016-4861-6

Cited by 30 publications

(36 citation statements)

References 36 publications

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“…Of 10 studies that compared arrhythmia rates, four studies reported the rate of bradycardia . The combined results showed no evidence for a difference (RR, 1.59; 95% CI, 0.75 to 3.35; P chi 2 = 0.042; I 2 = 44.59%; NNTH = 386.3; 95% CI, NNTH 25.6 to ∞ to NNTB 29.5).…”

Section: Resultsmentioning

confidence: 95%

Comparison of propofol monotherapy and propofol combination therapy for sedation during gastrointestinal endoscopy: A systematic review and meta‐analysis

Yoon

Choi

Lee

et al. 2018

Digestive Endoscopy

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Section: Resultsmentioning

confidence: 95%

Comparison of propofol monotherapy and propofol combination therapy for sedation during gastrointestinal endoscopy: A systematic review and meta‐analysis

Yoon

Choi

Lee

et al. 2018

Digestive Endoscopy

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“…Personalized medicine could have reduced the risk of hypoxia and excessive sedation in the P group. Therefore, just as Zhou et al [15] reported, etomidate plus propofol had few effects on respiration and circulation in patients undergoing gastroscopy and were safer and more effective than propofol alone.…”

Section: Discussionmentioning

confidence: 99%

“…Etomidate plus propofol had few effects on respiration and circulation in patients, and was safer and more effective than propofol alone. [15] However, the effect and the optimal dose of propofol to minimize side effects are not well established. Thus, this study investigated the effect of pretreatment with different doses of propofol on etomidate-related myoclonus in patients scheduled for painless gastroscopy.…”

Section: Introductionmentioning

confidence: 99%

Propofol decreases etomidate-related myoclonus in gastroscopy

Liu

Meng

et al. 2017

Medicine

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Objective:Myoclonus, a common complication during intravenous induction with etomidate, is bothersome to both anesthesiologists and patients. This study explored the preventive effect of pretreatment with propofol on etomidate-related myoclonus.Methods:This was a prospective, double-blind, clinical, randomized controlled study. Totally, 363 patients who were scheduled for a short-duration, painless gastrointestinal endoscopy were divided into 5 groups. Four groups received 0 mg/kg (E group), 0.25 mg/kg (LPE group), 0.50 mg/kg (MPE group), or 0.75 mg/kg (HPE group) propofol pretreatment before etomidate anesthesia. Another group only received 1 to 2 mg/kg of propofol (P group) as anesthesia. The incidence and severity of myoclonus, patient circulation and respiratory status, and intraoperative and postoperative complications were recorded.Results:The incidence of myoclonus in the LPE group (26.8%), MPE group (16.4%), HPE group (14.9%), and P group (0) was lower than the E group (48.6%, P < .05). The incidence of grade 1, 2, and 3 of myoclonus in the LPE group, MPE group, HPE group, and P group was significantly lower than the E group, and that in the P group was lower than the LPE group (P < .05). The incidence of hypoxemia in the P group was higher than the E group, and the incidence of adverse events in the HPE group and P group was lower than the E group (P < .05).Discussion:Pretreatment with propofol was feasible for preventing etomidate-related myoclonus. Furthermore, as propofol dosage increased, its effect on reducing the incidence and severity of myoclonic movements induced by etomidate increased.

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“…Previous study has shown that the physical and chemical properties of the admixture of propofol and etomidate have not changed, it can be safely used in clinical anesthesia, and its compatibility is stable. [ 11 ] Many researches have confirmed that the admixture of propofol and etomidate not only maintains the stability of the respiratory system of patients, but also reduces the incidence of adverse reactions such as injection pain, nausea and vomiting, [ 12 ] hypoxemia, [ 13 ] hypotension and oxygen desaturation. [ 14 ]…”

Section: Discussionmentioning

confidence: 99%

Clinical observation of the combined use of propofol and etomidate in painless gastroscopy

Zhu

et al. 2020

Medicine

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Etomidate plus propofol versus propofol alone for sedation during gastroscopy: a randomized prospective clinical trial

Abstract: Etomidate plus propofol had few effects on respiration and circulation in patients undergoing gastroscopy and was more safe and effective than propofol alone.

Cited by 30 publications

References 36 publications

Comparison of propofol monotherapy and propofol combination therapy for sedation during gastrointestinal endoscopy: A systematic review and meta‐analysis

Comparison of propofol monotherapy and propofol combination therapy for sedation during gastrointestinal endoscopy: A systematic review and meta‐analysis

Propofol decreases etomidate-related myoclonus in gastroscopy

Clinical observation of the combined use of propofol and etomidate in painless gastroscopy

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